Mechanisms of lung disease development in rheumatoid arthritis

Wang, Dan; Zhang, Jie; Lau, Julie S.; Wang, Shaohua; Taneja, Veena; Matteson, Eric L.; Vassallo, Robert

doi:10.1038/s41584-019-0275-x

Cited by 88 publications

(89 citation statements)

References 148 publications

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“…Our subgroup analysis comparing patients with CTD and those without showed that the majority of CTD was rheumatoid arthritis and many others with CPFE had autoantibodies related to rheumatoid arthritis, reinforcing the potential role of cigarette smoking in both diseases [26,27].…”

Section: Discussionsupporting

confidence: 57%

Automated computed tomography quantification of fibrosis predicts prognosis in combined pulmonary fibrosis and emphysema in a real-world setting-A single-centre, retrospective study

Nemoto

Nei

Bartholmai

et al. 2020

Preprint

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Background: Combined pulmonary fibrosis and emphysema (CPFE) is a heterogeneous clinico-radiological syndrome without a consensus definition. There are limited data on the relation between the amount of parenchymal fibrosis and prognosis. In this study, we assessed the prognostic implications of the extent of fibrosis assessed by an automated quantitative computed tomography (CT) technique and the radiological and functional change over time in patients with a broad spectrum of fibrotic interstitial lung diseases (ILDs) encountered in a real-world setting.Methods: We conducted a single-centre, retrospective study of 228 consecutive patients with CPFE, encountered from 2007 to 2015 at Kameda Medical Center, Chiba, Japan. We investigated the prognostic value of automated CT fibrosis quantification and the subsequent course of CPFE. Results: Among 228 patients with CPFE, 89 had fibrosis affecting <5% of their lungs, 54 had 5 to <10% fibrosis, and 85 had ≥10% fibrosis at the time of diagnosis. Lower volume of fibrosis correlated with lower rates of mortality and acute exacerbation (p<0.001). In particular, among those with <5% fibrosis, only 4.5% died and none experienced acute exacerbation during follow-up, whereas 57.6% and 29.4% of those with ≥10% fibrosis experienced death and acute exacerbation, respectively. The Cox proportional hazard model for CPFE progression (defined by composite criteria of death, acute exacerbation, and decline in forced vital capacity or diffusing capacity) showed fibrosis proportion was a risk factor independent of age, sex, smoking pack-years, the Charlson Comorbidity Index, lung cancer, connective tissue disease, and idiopathic pulmonary fibrosis.Conclusions: Less severe (<5%) fibrosis at baseline was associated with disease stability and better prognosis compared to more severe fibrosis in CPFE occurring with fibrotic ILDs. Further studies including a validation cohort will be needed.Trial Registration: retrospectively registered

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Section: Discussionsupporting

confidence: 57%

Automated computed tomography quantification of fibrosis predicts prognosis in combined pulmonary fibrosis and emphysema in a real-world setting-A single-centre, retrospective study

Nemoto

Nei

Bartholmai

et al. 2020

Preprint

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“…The presence of the shared epitope in HLA favours the binding of self-proteins that have undergone post-translational modification in a process referred to as citrullinationa physiological process that can be intensified by the presence of a risk allele in the PTPN22 gene, which is also a genetic risk factor for RA, as well as exposure to tobacco smoke [2]. In addition, gender (female), advanced age, and certain foods have been associated with increased risk for developing the disease [8].…”

Section: Introductionmentioning

confidence: 99%

Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression

Bauer

2020

Immun Ageing

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Patients with rheumatoid arthritis (RA) develop features of accelerated ageing, including immunosenescence. These changes include decreased thymic functionality, expansion of late-differentiated effector T cells, increased telomeric attrition, and excessive production of cytokines (senescence-associated secretory phenotype). The progression of RA has been associated with the early development of age-related co-morbidities, including osteoporosis, cardiovascular complications, and cognitive impairment. Here I review data supporting the hypothesis that immune-senescence contributes to the aggravation of both articular and extra-articular manifestations. Of note, poor cognitive functions in RA were associated with senescent CD28-T cells, inflammaging, and autoantibodies against brain antigens. The pathways of immune-to-brain communication are discussed and provide the rationale for the cognitive impairment reported in RA.

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“…Rheumatoid arthritis (RA) is a prevalent systemic autoimmune disease characterized by progressive joint destruction, and 50% of RA patients also have extra-articular involvement, including the heart, lungs, eyes, and blood (1,2). Globally, the overall incidence of RA is 40/100,000 people per year, with a prevalence of ∼0.24% (3,4), which is significantly higher in women (5).…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effects of Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Extracellular Vesicles in Rheumatoid Arthritis

Liu

et al. 2020

Front. Immunol.

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Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the joints and other organs for which there is currently no effective treatment. Mesenchymal stem cells (MSCs) have therapeutic potential due to their immunomodulatory and differentiation effects. While extensive experimental studies and clinical trials have demonstrated the effects of MSCs in various diseases, MSCs have been found to cause abnormal differentiation and tumor formation. Therefore, extracellular vesicles derived from MSCs (MSC-EVs) are more effective, less toxic, and more stable than the parental cells. MSC-EVs transfer various nucleic acids, proteins, and lipids from parent cells to recipient cells, and thus participate in chronic inflammatory and immune processes. In this review, we summarize the properties and biological functions of MSCs and MSC-EVs in RA. Improvement in our understanding of the mechanisms underlying MSC and MSC-EVs in RA provides an insight into potential biomarkers and therapeutic strategies for RA.

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Mechanisms of lung disease development in rheumatoid arthritis

Cited by 88 publications

References 148 publications

Automated computed tomography quantification of fibrosis predicts prognosis in combined pulmonary fibrosis and emphysema in a real-world setting-A single-centre, retrospective study

Automated computed tomography quantification of fibrosis predicts prognosis in combined pulmonary fibrosis and emphysema in a real-world setting-A single-centre, retrospective study

Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression

Immunomodulatory Effects of Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Extracellular Vesicles in Rheumatoid Arthritis

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