Mechanisms of Lung Development: Contribution to Adult Lung Disease and Relevance to Chronic Obstructive Pulmonary Disease

Sensitization of retinoids and corticoids to epigenetic drugs in MYC-activated lung cancers by antitumor reprogramming

“…39,40 It is also well established the importance of GCs in perinatal lung development. 41,42 However, these compounds have therapeutic effects on some childhood and hematological malignancies [20][21][22] but not in lung cancer or most solid tumors. 42,43 There is a physical interaction between components of the SWI/ SNF complex and the RA and GC receptors and there is evidence of nucleosome-disrupting activity of the complex to allow transcription mediated by RA and GC receptors.…”

Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes

“…35 It has been shown to play a role in critical processes directly involved in perinatal transitioning of the embryonic lung into a mature functional organ. 35 Hedgehog-interacting protein (HHIP) has been implicated in organ development and repair in multiple tissues 36 and is therefore a strong candidate gene for COPD. Our findings of HHIP SNP rs1828591 risk alleles being associated with an increased risk of TEW and lower lung function support our hypothesis.…”

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

“…An important example concerns transforming growth factor beta (TGF)-b signalling: appropriate levels of TGF-b are crucial to lung development [8] but excessive levels in the adult lung promote progressive fibrosis [9,10], the hallmark of remodelling. Likewise, the vascular endothelial growth factor (VEGF) has a crucial role in the development of normal lung circulation in the foetus and the newborn [11].…”

“…Applied to the lung, this hypothesis points to a connection between impaired lung development and chronic lung disease. This connection relates, on the one hand, to long-term changes in lung structure and metabolism due to noxae encountered early in life, with the potential for generating a maladaptive response to harmful agents in adulthood [8]. However, it relates to the reiteration of developmental mechanisms and pathways in the pathogenesis of lung disease [2].…”