Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease

Abstract

Pulmonary tuberculosis is increasingly recognized as a risk factor for COPD. Severe lung function impairment has been reported in post-TB patients. Despite increasing evidence to support the association between TB and COPD, only a few studies describe the immunological basis of COPD among TB patients following successful treatment completion. In this review, we draw on well-elaborated Mycobacterium tuberculosis-induced immune mechanisms in the lungs to highlight shared mechanisms for COPD pathogenesis in the setting of tuberculosis disease. We further examine how such mechanisms could be exploited to guide COPD therapeutics.

Recurrent Pneumothorax in a Patient with Post-Tuberculosis Sequelae: A Case Report

“…The interaction of host response, along with the respiratory epithelial cells, extracellular matrix and fibroblasts will culminate in continuous chronic lung inflammation, causing the necrosis of tissues also airway remodeling, as the result, there would be structural changes and these changes gradually compromise lung function. 13 A pneumothorax is a condition in which an air from outside of the lung is trapped within the pleural cavity. This could leads to many problems related with ventila- in a patient with pre-existing lung disease, patient in this case has a history of lung tuberculosis, therefore his pneumothorax can be classified as SSP.…”