Mechanisms of interaction betweenCandida albicansandStreptococcus mutans: An experimental and mathematical modelling study

Abstract

The results suggest that C. albicans biofilm formation could be potentiated by the presence of S. mutans by two mechanisms: synergically at short times and by competition at longer periods.

The Effect of a Continuous Mechanical Polishing Protocol on Surface Roughness, Biofilm Adhesion, and Color Stability of Acrylic Resin Artificial Teeth

“…A multispecies biofilm formation assay was employed in triplicate, using standard strains of Streptococcus mutans (ATCC 25175) and Candida albicans (ATCC 10231). S. mutans plays a role in the biofilm initiation and facilitates the adherence of yeasts in the mucosa, as well as the prosthetic surfaces, and C. albicans is the most prevalent yeast in oral infections associated with the usage of removable dentures …”

Mathematical Modeling of Regenerative Processes

“…10.1D). This model was successfully applied in many fields including ecology (Sibly, Barker, Denham, Hone, & Pagel, 2005) as well as microbiology (Brusca, Irastorza, Cattoni, Ozu, & Chara, 2013) among many others.…”

Microbial cell surface proteins and secreted metabolites involved in multispecies biofilms

“…It is most likely however that the interaction is mutualistic, because S. mutans promotes adhesion and growth of C. albicans, and fungal stimulatory factors have been shown to stimulate the growth of the bacteria (Pereira-Cenci et al, 2008). Recently, combined mathematical and experimental modeling showed that S. mutans might promote co-colonization with C. albicans in the beginning of biofilm formation, but this synergistic relationship may become antagonistic at a later stage (Brusca et al, 2013). This is in line with findings from previous studies demonstrating that the S. mutans signaling molecule trans-2-decenoic acid and a competence-stimulating peptide inhibit the yeast-hyphae transition in C. albicans (Jarosz et al, 2009;Vilchez et al, 2010).…”