Mechanisms of Impaired Gallbladder Contractile Response in Chronic Acalculous Cholecystitis

Merg, Anders; Kalinowski, Scott E.; Hinkhouse, Marilyn M.; Mitros, Frank A.; Ephgrave, Kimberly S.; Cullen, Joseph J.

doi:10.1016/s1091-255x(01)00061-0

Cited by 24 publications

(22 citation statements)

References 15 publications

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“…We found that both CCK‐8 and ionomycin induced a reduced myoelectric activity in CC group, but the myoelectric activity induced by CCK‐8 was even lower. These results are comparable to the other studies using the traditional method of isometric tension measurement of smooth muscle strips in inflammatory diseases, 17,37–39 indicating that myoelectric activity of SO associated with Ca 2+ mobilization was impaired by chronic cholangitis. In comparison with isometric tension measurement in which only part of smooth muscle cells in the SO were detected, however, myoelectric activities recorded by circular electrode represent the myoelectrical activity of all smooth muscle cells in an integrated SO, which is better than isometric tension to reflect the functional status of entire SO.…”

Section: Discussionsupporting

confidence: 88%

Reduced myoelectric activity in the sphincter of Oddi in a new model of chronic cholangitis in rabbits: an in vivo and in vitro study

Liu

et al. 2010

Neurogastroenterology Motil

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Section: Discussionsupporting

confidence: 88%

Reduced myoelectric activity in the sphincter of Oddi in a new model of chronic cholangitis in rabbits: an in vivo and in vitro study

Liu

et al. 2010

Neurogastroenterology Motil

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“…Although the mechanisms underlying impaired gallbladder emptying have not been completely elucidated, the existence of a general defect in the contractile apparatus, not a specific abnormality of CCK1R or impaired nerve-induced contractile responses, has been recently hypothesized in impaired gallbladder function of patients with acalculous cholecystitis (11,312). The muscle cell defect appears to be specific for this condition and not for gallbladder disease with cholesterol gallstones.…”

Section: Gallbladder Diseasesmentioning

confidence: 98%

Cholecystokinin and Gastrin Receptors

Dufresne

Seva²,

Fourmy³

2006

Physiological Reviews

417

418

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Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled receptors that have been the subject of intensive research in the last 10 years with corresponding advances in the understanding of their functioning and physiology. In this review, we first describe general properties of the receptors, such as the different signaling pathways used to exert short- and long-term effects and the structural data that explain their binding properties, activation, and regulation. We then focus on peripheral cholecystokinin receptors by describing their tissue distribution and physiological actions. Finally, pathophysiological peripheral actions of cholecystokinin receptors and their relevance in clinical disorders are reviewed.

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“…An abnormality in the smooth muscle layer of the gallbladder causing impaired gallbladder emptying was proposed by Merg et al [20], who showed a higher incidence of chronic cholecystitis in patients with GBD as compared to normal subjects. Indeed, in vitro studies [21] showed that patients with GBD had a higher incidence of absence of spontaneous contractile activity and decreased contractile response to CCK and electrical field stimulation.…”

Section: Pathogenesismentioning

confidence: 99%

Gallbladder Dysfunction: How Much Longer Will It Be Controversial?

Goussous¹,

Kowdley²,

Sardana³

et al. 2014

Digestion

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Background: Motility disorders of the biliary tree [biliary dyskinesia, including both gallbladder dysfunction (GBD), and sphincter of Oddi dysfunction] are difficult to diagnose and to treat. Summary: There is controversy in the literature in particular regarding the criteria that should be used to select patients for cholecystectomy (CCY) in cases of suspected GBD. The current review covers the history, diagnosis, and treatment of GBD. Key Messages: Only >85% of patients with suspected GBD have relief following CCY, a much lower rate than the nearly 100% success rate following CCY for gallstone disease. Unfortunately, the literature is lacking, and there are no universally agreed-upon criteria for selecting which patients to refer for operation, although cholecystokinin (CCK)-enhanced hepatobiliary iminodiacetic acid scan is often used, with emphasis on an abnormally low gallbladder ejection fraction or pain reproduction at CCK administration. There is a clear need for large, well-designed, more definitive, prospective studies to better identify the indications for and efficacy of CCY in cases of GBD. i 2014 S. Karger AG, Basel

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Mechanisms of Impaired Gallbladder Contractile Response in Chronic Acalculous Cholecystitis

Cited by 24 publications

References 15 publications

Reduced myoelectric activity in the sphincter of Oddi in a new model of chronic cholangitis in rabbits: an in vivo and in vitro study

Reduced myoelectric activity in the sphincter of Oddi in a new model of chronic cholangitis in rabbits: an in vivo and in vitro study

Cholecystokinin and Gastrin Receptors

Gallbladder Dysfunction: How Much Longer Will It Be Controversial?

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