Mechanisms of immune response to inorganic nanoparticles and their degradation products

Mohammadpour, Raziye; Ghandehari, Hamidreza

doi:10.1016/j.addr.2021.114022

Cited by 53 publications

(43 citation statements)

References 190 publications

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“…However, understanding these facets is not sufficient. To realize the clinical transformation of MSNs, only investigating the acute toxicity and subacute toxicity of nanoparticles cannot fully reflect their biological toxicity (Hosseinpour et al, 2020;Mohammapdour and Ghandehari, 2022). It is necessary to understand the toxicity of nanoparticles to various types of cells in vivo.…”

Section: Biological Toxicity Of Msnsmentioning

confidence: 99%

Applications and Biocompatibility of Mesoporous Silica Nanocarriers in the Field of Medicine

et al. 2022

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Mesoporous silica nanocarrier (MSN) preparations have a wide range of medical applications. Studying the biocompatibility of MSN is an important part of clinical transformation. Scientists have developed different types of mesoporous silica nanocarriers (MSNs) for different applications to realize the great potential of MSNs in the field of biomedicine, especially in tumor treatment. MSNs have achieved good results in diagnostic bioimaging, tissue engineering, cancer treatment, vaccine development, biomaterial application and diagnostics. MSNs can improve the therapeutic efficiency of drugs, introduce new drug delivery strategies, and provide advantages that traditional drugs lack. It is necessary not only to innovate MSNs but also to comprehensively understand their biological distribution. In this review, we summarize the various medical uses of MSN preparations and explore the factors that affect their distribution and biocompatibility in the body based on metabolism. Designing more reasonable therapeutic nanomedicine is an important task for the further development of the potential clinical applications of MSNs.

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Section: Biological Toxicity Of Msnsmentioning

confidence: 99%

Applications and Biocompatibility of Mesoporous Silica Nanocarriers in the Field of Medicine

et al. 2022

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“…In addition, carbon-based materials are good candidates as delivery carriers due to the high specific surface area and π-π stacking interaction for drug loading [64]. However, their biodegradability and biocompatibility might be a concern prior to the clinical applications of carbon-based materials [65].…”

Section: Liposomesmentioning

confidence: 99%

Advances in Delivering Oxidative Modulators for Disease Therapy

Wei

Yue

et al. 2022

Research

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Oxidation modulators regarding antioxidants and reactive oxygen species (ROS) inducers have been used for the treatment of many diseases. However, a systematic review that refers to delivery system for divergent modulation of oxidative level within the biomedical scope is lacking. To provide a comprehensive summarization and analysis, we review pilot designs for delivering the oxidative modulators and the main applications for inflammatory treatment and tumor therapy. On the one hand, the antioxidants based delivery system can be employed to downregulate ROS levels at inflammatory sites to treat inflammatory diseases (e.g., skin repair, bone-related diseases, organ dysfunction, and neurodegenerative diseases). On the other hand, the ROS inducers based delivery system can be employed to upregulate ROS levels at the tumor site to kill tumor cells (e.g., disrupt the endogenous oxidative balance and induce lethal levels of ROS). Besides the current designs of delivery systems for oxidative modulators and the main application cases, prospects for future research are also provided to identify intelligent strategies and inspire new concepts for delivering oxidative modulators.

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“…Therefore, artificial enzymes are the best candidates for treating dysregulated redox homeostasis. [67][68][69] Hu et al reported that a polyvinylpyrrolidone-stabilized MoSe 2 nanoparticle (MoSe 2 -PVP NPs) could be easily prepared. 70 The MoSe 2 -PVP NPs effectively simulates various natural enzymes, and eliminates free radicals such as •OH, •O 2 − and 3-ethylbenzothiazoline-6-sulfonic acid.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

A Mini-Review of Diagnostic and Therapeutic Nano-Tools for Pancreatitis

Zhang¹,

Li²,

Yang³

et al. 2022

IJN

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Pancreatitis is an inflammatory reaction of pancreatic tissue digestion, edema, bleeding and even necrosis caused by activation of pancreatin due to various causes. In particular, patients with severe acute pancreatitis (SAP) often suffer from secondary infection, peritonitis and shock, and have a high mortality rate. Chronic pancreatitis (CP) can cause permanent damage to the pancreas. Due to the innate characteristics, structure and location of the pancreas, there is no effective treatment, only relief of symptoms. Especially, AP is an unpredictable and potentially fatal disease, and the timely diagnosis and treatment remains a major challenge. With the rapid development of nanomedicine technology, many potential tools can be used to address this problem. In this review, we have introduced the pathophysiological processes of pancreatitis to understanding its etiology and severity. Most importantly, the current progress in the diagnosis and treatment tools of pancreatitis based on nanomedicine is summarized and prospected.

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Mechanisms of immune response to inorganic nanoparticles and their degradation products

Cited by 53 publications

References 190 publications

Applications and Biocompatibility of Mesoporous Silica Nanocarriers in the Field of Medicine

Applications and Biocompatibility of Mesoporous Silica Nanocarriers in the Field of Medicine

Advances in Delivering Oxidative Modulators for Disease Therapy

A Mini-Review of Diagnostic and Therapeutic Nano-Tools for Pancreatitis

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