Mechanisms of Hypocholesterolemia

Malmendier, Claude; Lontie, Jean-Francois; Dubois, D.Y.

doi:10.1007/978-1-4684-5904-3_22

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…APOA4 modulates the activation of LPL by APOC2 (Goldberg et al, 1990) and participates in reverse cholesterol transport (Stein et al, 1986). The transcription of APOA4 is regulated synchronously with that of APOA1, supporting the relationship between these apolipoproteins (Malmendier, Alaupovic & Brewer, 1991) and APOA4 is associated with TG and HDL levels. APOA5 is a component of HDL and regulates TG levels via hydrolysis of TG-rich lipoproteins and endocytosis of lipoprotein remnants (Forte, Shu & Ryan, 2009).…”

Section: Introductionmentioning

confidence: 56%

Functional polymorphisms of the APOA1/C3/A4/A5-ZPR1-BUD13 gene cluster are associated with dyslipidemia in a sex-specific pattern

Bai

Kou

Zhang

et al. 2019

PeerJ

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BackgroundDyslipidemia contributes to the risk of many diseases, including stroke, cardiovascular disease and metabolic-related diseases. Previous studies have indicated that single nucleotide polymorphisms (SNPs) are associated with different levels of serum lipid. Therefore, this study explored the relationship between the APOA1/C3/A4/A5-ZPR1-BUD13 gene cluster gene polymorphisms and dyslipidemia in the total sample population and stratified by genders in a northeast Chinese population.MethodsA total of 3,850 participants from Jilin Province, China, were enrolled in our study, and their serum lipid levels were measured. Six functional SNPs (APOA1 rs5072, APOC3 rs5128, APOA4 rs5104, APOA5 rs651821, ZPR1 rs2075294 and BUD13 rs10488698) were genotyped using polymerase chain reaction and MALDI-TOF-MS. Logistic regression analysis was performed to explore the relationship of APOA1/C3/A4/A5-ZPR1-BUD13 gene cluster gene polymorphisms with dyslipidemia. Linkage disequilibrium and haplotype analyses were performed with the SNPStats program and Haploview software.ResultsAll SNPs conformed to Hardy–Weinberg equilibrium. Logistic regression analysis revealed that rs5072, rs5128 and rs651821 were associated with hypertriglyceridemia, rs5104 and rs651821 were associated with low-HDL cholesterolemia in overall group. rs651821 was associated with hypertriglyceridemia and low-HDL cholesterolemia in both the male and female group. However, among females, rs5072 was observed to be associated with hypertriglyceridemia. Haplotype analysis showed that haplotypes TGCCGC and CAGCGC were associated with dyslipidemia in the overall, male and female groups.ConclusionSNPs in the APOA1/C3/A4/A5-ZPR1-BUD13 gene cluster were associated with dyslipidemia. Furthermore, the association of APOA1 rs5072 in this gene cluster with dyslipidemia differed between genders; thus, additional studies are needed to confirm this conclusion, and the mechanisms underlying these results warrant further exploration.

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Section: Introductionmentioning

confidence: 56%

Functional polymorphisms of the APOA1/C3/A4/A5-ZPR1-BUD13 gene cluster are associated with dyslipidemia in a sex-specific pattern

Bai

Kou

Zhang

et al. 2019

PeerJ

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“…Hypertriglyceridemia was significantly higher in severe VL cases than mild/moderate group. Lipid disorders along with hypertriglyceridemia in VL cases have been reported earlier but none of them has ever studied the correlation between magnitude of serum triglyceride and the disease severity [16][17][18][19][20][21][22][23][26][27][28]. Recently, a study conducted on in vitro development of Leishmania donovani promastigotes exhibited that triglycerides are very much essential for Leishmania parasite growth [31].…”

Section: Discussionmentioning

confidence: 97%

“…The first case was reported in 1982 that described lipid disorders in an adult patient with kala-azar [16]. Thereafter, several studies revealed lipid disorders in children with active VL [17][18][19][20][21]. Severe hypocholesterolemia with reduced serum lipoprotein-alpha was reported in an adult patient with VL [22].…”

Section: Introductionmentioning

confidence: 97%

Hypertriglyceridemia: a possible diagnostic marker of disease severity in visceral leishmaniasis

Lal

Verma

et al. 2015

Infection

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“…Therefore, in patients with VL, the reduction in HDL and LDL lipoproteins may be because of sequestration and degradation of these lipoproteins in the spleen and liver, which are organs that have high concentrations of Leishmania. 6,12 Other hypotheses to explain the reduction of HDL in serum include cytokine release during the acute phase response of the disease, which would have an inhibitory effect on lecithin cholesterol acyltransferase. 13 Furthermore, hypergammaglobulinemia and elevated serum b2-microglobulin levels described in VL patients 6,14 can affect cholesterol metabolism via the formation of immune complexes between HDL and antibodies, which would accelerate lipoprotein degradation, or the impairment of lipoprotein lipase activity, which is responsible for breaking down lipoproteins in the plasma so that the tissue can absorb its components, mainly cholesterol.…”

Section: Discussionmentioning

confidence: 99%

Association between Hypertriglyceridemia and Disease Severity in Visceral Leishmaniasis

Varela

Bezerra

Santana

et al. 2022

The American Journal of Tropical Medicine and Hygiene

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Visceral leishmaniasis (VL) is a tropical disease endemic to Brazil. The clinical manifestations of the infection range from asymptomatic to severe. In VL, changes in lipid metabolism, such as hypocholesterolemia and hypertriglyceridemia, occur that are believed to be related to its progression and severity. This study investigated the associations between serum levels of cholesterol, triglycerides, and lipoproteins (high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein) with clinical and hematological parameters that predict severity in a case series of 83 VL patients. Severely ill patients had higher mean serum triglyceride levels than non-severely ill patients. There was a significant positive correlation between disease severity score and serum triglyceride levels, very low-density lipoprotein, international normalized ratio for prothrombin time test, total bilirubin, and age. An inverse correlation was detected between the disease severity score and mean platelet and neutrophil counts. Hypertriglyceridemia can be a prognostic indicator of severity in patients diagnosed with VL.

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Mechanisms of Hypocholesterolemia

Cited by 8 publications

References 36 publications

Functional polymorphisms of the APOA1/C3/A4/A5-ZPR1-BUD13 gene cluster are associated with dyslipidemia in a sex-specific pattern

Functional polymorphisms of the APOA1/C3/A4/A5-ZPR1-BUD13 gene cluster are associated with dyslipidemia in a sex-specific pattern

Hypertriglyceridemia: a possible diagnostic marker of disease severity in visceral leishmaniasis

Association between Hypertriglyceridemia and Disease Severity in Visceral Leishmaniasis

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