Mechanisms of hedgehog, calcium and retinoic acid signalling pathway inhibitors: Plausible modes of action along the MLL–EZH2-p53 axis in cellular growth control

Manna, Subal Chandra; Kirtana, R.; Roy, Ankan; Baral, Tirthankar; Patra, Samir Kumar

doi:10.1016/j.abb.2023.109600

Cited by 6 publications

(1 citation statement)

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“…In addition, human oral squamous cell carcinoma cells showed an increase in ROS after being treated with areca extract. Studies have shown that ROS can promote the biological behavior changes of oral cancer cells, induce epithelial–mesenchymal transformation of oral cancer cells, and further develop metastasis and proliferation of cancer cells[ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

Yin,

Yao,

et al. 2024

World J Clin Cases

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BACKGROUND Oral cancer, which is caused by mucous membrane variation, represents a prevalent malignant tumor in the oral and maxillofacial region, posing a significant threat to patients’ lives and safety. While surgical intervention stands as a cornerstone treatment for oral cancer patients, it carries the risk of incomplete treatment or high rates of postoperative recurrence. Hence, a multifaceted approach incorporating diverse treatment modalities is essential to enhance patient prognosis. AIM To analyze the application effect of Tongluo Jiedu prescription as adjuvant therapy and its influence on patient prognosis in patients with oral cancer. METHODS Eighty oral cancer patients in our hospital were selected and divided into the observation group and control group by a random number table. The control group was treated with continuous arterial infusion chemotherapy of cisplatin and 5-fluorouracil. The observation group was additionally given Tongluo Jiadu prescription. The inflammatory stress level, peripheral blood T-cell subsets, and immune function of the two groups were subsequently observed. SPSS 21.0 was used for data analysis. RESULTS The observation group demonstrated lower levels of interleukin-6 and C-reactive protein, and a higher level of tumor necrosis factor in comparison to the control group. After treatment, the immune function in the observation group was significantly better than in the control group. CONCLUSION Tongluo Jiedu prescription can improve the immune function and oxidative stress level of patients with oral cancer and accelerate the recovery process.

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Section: Discussionmentioning

confidence: 99%