Mechanisms of hearing loss from trauma and inflammation: otoprotective therapies from the laboratory to the clinic

Water, Thomas R. Van De; Dinh, Christine T.; Vivero, Richard J.; Hoosien, Gia; Eshraghi, Adrien A.; Bałkany, Thomas J.

doi:10.1080/00016480903124655

Cited by 23 publications

(18 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dexamethasone is known to have protective effects against insertion trauma as well as inflammatory process after implantation [9]. In this series, intraoperative infusion and postoperative dexamethasone treatment was administered systemically.…”

Section: Discussionmentioning

confidence: 99%

Achievement of hearing preservation in the presence of an electrode covering the residual hearing region

Usami¹,

Moteki²,

Suzuki³

et al. 2011

Acta Oto-Laryngologica

View full text Add to dashboard Cite

Conclusions:With full insertion with a long electrode, hearing preservation can be achieved even in the presence of a long electrode covering the residual hearing region.Objectives:Advances in developing new atraumatic concepts of electrode design as well as surgical technique have enabled hearing preservation after cochlear implantation surgery, and EAS (electric acoustic stimulation) accompanied with hearing preservation is a new trend for patients with residual hearing at the lower frequencies. However, full insertion with a long/medium electrode and hearing preservation is still a challenging field that calls for discussion.Method:In this study, round window insertion, an atraumatic electrode, and dexamethasone administration were used and atraumaticity (hearing preservation and conservation of vestibular function) was evaluated with full insertion of the electrode.Results:Postoperative evaluation after full insertion of the electrodes showed that hearing at low frequencies was well preserved in all five cases. Combined postoperative imaging with the referential tonotopic map confirmed achievement of full insertion and indicated the corresponding frequencies and the depth of the electrode. Achievement of atraumaticity of round window insertion in the present cases was confirmed from the viewpoint of the minimal drilling time as well as the preserved vestibular function.

show abstract

Section: Discussionmentioning

confidence: 99%

Achievement of hearing preservation in the presence of an electrode covering the residual hearing region

Usami¹,

Moteki²,

Suzuki³

et al. 2011

Acta Oto-Laryngologica

View full text Add to dashboard Cite

show abstract

“…When added to cochlear explants, TNF- α leads to hair cell death in vitro (21–22); its effects can be reversed by dexamethasone administration (23). Interestingly, TNF-α is localized not just in the organ of Corti, but also to Type I fibrocytes and root cells in the spiral ligament where it mediates capillary constriction and reduction of cochlear blood flow (24–25).…”

Section: Introductionmentioning

confidence: 99%

Changes in Gene Expression and Hearing Thresholds After Cochlear Implantation

Zhang

Stark

Reiss³

2015

Otology &Amp; Neurotology

View full text Add to dashboard Cite

Hypothesis Gene expression changes occur in conjunction with hearing threshold changes after cochlear implantation. Background Between 30–50% of individuals who receive electro-acoustic stimulation (EAS) cochlear implants lose residual hearing after cochlear implantation, reducing the benefits of EAS. The mechanism underlying this hearing loss is unknown; potential pathways include mechanical damage, inflammation, or tissue remodeling changes. Methods Guinea pigs were implanted in one ear with cochlear implant electrode arrays, with non-implanted ears serving as controls, and allowed to recover for 1, 3, 7, or 14 days. Hearing threshold changes were measured over time. Cochlear ribonucleic acid was analyzed using real-time quantitative reverse transcription-polymerase chain reaction from the following gene families: cytokines, tight junction claudins, ion and water (aquaporin) transport channels, gap junction connexins, and tissue remodeling genes. Results Significant increases in expression were observed for cochlear inflammatory genes (Cxcl1, IL-1b, TNFα and Tnfrsf1a/b) and ion homeostasis genes (Scnn1γ, Aqp3 and Gjb3). Upregulation of tissue remodeling genes (TGF-β, MMP2, MMP9) as well as a paracrine gene (CTGF) was also observed. Hearing loss occurred rapidly, peaking at 3 days with some recovery at 7 and 14 days after implantation. MM9 exhibited extreme upregulation of expression and was qualitatively associated with changes in hearing thresholds. Conclusion Cochlear implantation induces similar changes as middle ear inflammation for genes involved in inflammation and ion and water transport function, whereas tissue remodeling changes differ markedly. The upregulation of MMP9 with hearing loss is consistent with previous findings linking stria vascularis vessel changes with cochlear implant-induced hearing loss.

show abstract

“…In this regard, the importance of residual hearing was magnified, and the preservation of residual hearing has been one of the major issues in CI. For hearing preservation (HP), a less traumatic electrode array was developed to minimize inner ear trauma during surgery, and an atraumatic surgical technique, 'soft surgery', was applied to reduce insertion trauma as well as inflammatory response [van de Water et al, 2010]. Additionally, steroids have been applied in conjunction with an atraumatic surgical technique in order to decrease the direct mechanical trauma and detrimental tissue changes after CI.…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone Is One of the Factors Minimizing the Inner Ear Damage from Electrode Insertion in Cochlear Implantation

et al. 2016

View full text Add to dashboard Cite

The aim of this study was to investigate the efficacy of preoperative and intraoperative steroid administration for inner ear protection in cochlear implantation (CI). Nineteen subjects who underwent CI were included in the study, and 10 subjects were enrolled as controls (steroid-administered group, n = 19; control group, n = 10). Dexamethasone (dexamethasone sodium phosphate, 5 mg/ml) was systemically administered preoperatively (1 ml) and topically applied during CI (0.5 ml). The extent of hearing preservation (HP) after CI and the change in the bithermal caloric response were evaluated. Hearing level was calculated using mean thresholds [(250 Hz + 500 Hz + 1,000 Hz + 2,000 Hz)/4]. Preoperative hearing thresholds were similar in the steroid-administered and control groups (100.92 ± 12.60 vs. 103.29 ± 14.39 dB, p = 0.650). The mean thresholds significantly increased in both groups after surgery (108.46 ± 14.08 dB, p = 0.006, for the steroid-administered group; 117.50 ± 6.34 dB, p = 0.027, for the control group), and the difference between the groups was also significant (p = 0.027). The postoperative shift in the hearing thresholds at frequencies of 500 and 1,000 Hz was significant in the steroid-administered group and that at the frequencies of 500, 1,000 and 2,000 Hz was significant in the control group. However, the extent of the shift in hearing threshold levels at each frequency was not significantly different between the groups. Preservation of hearing thresholds was compared between the groups, and there were significantly more subjects with complete and partial HP in the steroid-administered group than in the control group (p = 0.008). The preoperative caloric response was maintained after CI in the steroid-administered group. This study suggests that the perioperative use of a steroid could minimize the inner ear damage after CI.

show abstract

Mechanisms of hearing loss from trauma and inflammation: otoprotective therapies from the laboratory to the clinic

Cited by 23 publications

References 18 publications

Achievement of hearing preservation in the presence of an electrode covering the residual hearing region

Achievement of hearing preservation in the presence of an electrode covering the residual hearing region

Changes in Gene Expression and Hearing Thresholds After Cochlear Implantation

Dexamethasone Is One of the Factors Minimizing the Inner Ear Damage from Electrode Insertion in Cochlear Implantation

Contact Info

Product

Resources

About