Mechanisms of G1 checkpoint loss in resected early stage non-small cell lung cancer

Zhou, Joan; Niehans, Gloria A.; Shar, Alexander; Rubins, Jeffrey B.; Frizelle, Sandra; Kratzke, Robert A.

doi:10.1016/s0169-5002(00)00210-5

Cited by 22 publications

(20 citation statements)

References 25 publications

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“…4). This result is in agreement with numerous data published about the cell-cycle checkpoints investigated in this paper and lung cancer (Esposito et al, 1997a;Caputi et al, 1998;Groeger et al, 1999;Mitsudomi et al, 2000;Zhou et al, 2001;Kaye, 2002;Shoji et al, 2002). As expected, the lymph nodes status and clinical tumor stage were significantly correlated with survival as well.…”

Section: The Cell-cycle Machinery and Lung Cancersupporting

confidence: 93%

Role of cell‐cycle regulators in lung cancer

Caputi

Russo

Esposito

et al. 2005

Journal Cellular Physiology

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Lung cancer is the leading cause of cancer death worldwide. Histologically, 80% of lung cancers are classified as non-smallcell lung cancer (NSCLC), and the remaining 20% as small-cell lung cancer (SCLC). Lung carcinoma is the result of molecular changes in the cell, resulting in the deregulation of pathways controlling normal cellular growth, differentiation, and apoptosis. This review summarizes some of the most recent findings about the role of cell-cycle proteins in lung cancer pathogenesis and progression.

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Section: The Cell-cycle Machinery and Lung Cancersupporting

confidence: 93%

Role of cell‐cycle regulators in lung cancer

Caputi

Russo

Esposito

et al. 2005

Journal Cellular Physiology

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“…Changes in cell cycle -related proteins, especially Ki-67 overexpression, dysregulation of the Rb-cyclin D1-p16 pathway and p53-p21 WAF1 alterations, are very common biomarkers for lung cancer (31). In fact, several reports have shown that 90% of lung tumors have at least one of the Rb pathway proteins altered (32)(33)(34). In our series of early lung tumors, we have evaluated three Rb pathway proteins and, in agreement with other reports, we have observed modifications of at least one protein of this pathway in 80% to 90% of the tumors both in the screening and the nonscreening groups.…”

Section: Discussionmentioning

confidence: 99%

Molecular Profiling of Computed Tomography Screen-Detected Lung Nodules Shows Multiple Malignant Features

Pajares¹,

Zudaire²,

Lozano³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Rationale and Purpose: Low-dose spiral computerized axial tomography (spiral CT) is effective for the detection of small early lung cancers. Although published data seem promising, there has been a significant degree of discussion concerning the potential of overdiagnosis in the context of spiral CT -based screening. The objective of the current study was to analyze the phenotypic and genetic alterations in the small pulmonary malignancies resected after detection in the University of Navarra/International Early Lung Cancer Action Project spiral CT screening trial and to determine whether their malignant molecular features are similar to those of resected lung tumors diagnosed conventionally. Experimental Design: We analyzed 17 biomarkers of lung epithelial malignancy in a series of 11 tumors resected at our institution during the last 4 years (1,004 high-risk individuals screened), using immunohistochemistry and fluorescence in situ hybridization (FISH). A parallel series of 11 gender-, stage-, and histology-matched lung cancers diagnosed by other means except screening was used as control. Results: The molecular alterations and the frequency of phenotypic or genetic aberrations were very similar when screen-detected and nonscreen-detected lung cancers were compared. Furthermore, most of the alterations found in the screen-detected cancers from this study were concordant with what has been described previously for stage I-II lung cancer. Conclusions: Small early-stage lung cancers resected after detection in a spiral CT-based screening trial reveal malignant molecular features similar to those found in conventionally diagnosed lung cancers, suggesting that the screen-detected cancers are not overdiagnosed. (Cancer Epidemiol Biomarkers Prev 2006;15(2):373 -80)

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“…progression from G1 to S phase, which can promote the proliferation of cells [29,30]. Bcl-2 is a kind of anti-apoptosis protein that inhibit cell cycle transforming of G1/S, which promote cell survival and inhibit cell apoptosis [31].…”

Section: Cellular Physiology and Biochemistrymentioning

confidence: 99%

Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway

Wang

et al. 2016

Cell Physiol Biochem

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Background/Aims: Microarray screening had found BRAF-activated non-coding RNA (BANCR) was significantly upregulated in type 1 endometrial cancer (EC). This study aimed to assess the potential role of long non-coding RNA (lncRNA) BANCR in the pathogenesis and progression of type 1 EC. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to confirm the expression of BANCR in type 1 EC tissue, and analyze its clinical significance. In vitro, RNA interference (siRNA) was used to investigate the biological role of BANCR in type 1 EC. Results: qRT-PCR revealed that the expression of lncRNA BANCR was higher in type 1 EC (P<0.01). BANCR expression was significantly correlated with FIGO stage, pathological grade, myometrial invasion, and lymph node metastasis. The expression of BANCR was significantly correlated with that of MMP2/MMP1. In vitro, knockdown of BANCR significantly suppressed proliferation, migration, and invasion of Ishikawa and HEC-1A cells, and significantly inhibited the ERK/MAPK signaling pathway that decreased MMP2 and MMP1 expression. Conclusion: BANCR is highly expressed in type 1 EC tissue and promotes EC-cell proliferation, migration, and invasion by activating ERK/MAPK signaling pathway that regulates MMP2/MMP1 expression. BANCR is expected to become a prognostic marker and therapeutic target in type 1 EC.

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Mechanisms of G1 checkpoint loss in resected early stage non-small cell lung cancer

Cited by 22 publications

References 25 publications

Role of cell‐cycle regulators in lung cancer

Role of cell‐cycle regulators in lung cancer

Molecular Profiling of Computed Tomography Screen-Detected Lung Nodules Shows Multiple Malignant Features

Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway

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