Mechanisms of Formation of Antibodies against Blood Group Antigens That Do Not Exist in the Body
Alexander A. Mironov,
Maksim A. Savin,
Anna V. Zaitseva
et al.
Abstract:The system of the four different human blood groups is based on the oligosaccharide antigens A or B, which are located on the surface of blood cells and other cells including endothelial cells, attached to the membrane proteins or lipids. After transfusion, the presence of these antigens on the apical surface of endothelial cells could induce an immunological reaction against the host. The final oligosaccharide sequence of AgA consists of Gal-GlcNAc-Gal (GalNAc)-Fuc. AgB contains Gal-GlcNAc-Gal (Gal)-Fuc. Thes… Show more
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