Mechanisms of formation and disintegration of alginate beads obtained by prilling

Gaudio, Pasquale Del; Colombo, Paolo; Colombo, Gaia; Russo, Paola; Sonvico, Fabio

doi:10.1016/j.ijpharm.2005.05.041

Cited by 132 publications

(71 citation statements)

References 24 publications

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“…The density measurement of many biopolymer solutions is frequently conducted using the static densitometer such as pycnometer [6][7][8] and vibrating element digital densitometer [9,10]. These densitometers are able to measure density of viscous liquid like biopolymer solutions accurately [11].…”

Section: Introductionmentioning

confidence: 99%

“…These densitometers are able to measure density of viscous liquid like biopolymer solutions accurately [11]. In general, the density of many biopolymer solutions is reported to be in the range of 1.00-1.02 g/ml [6,[8][9][10], which is close to that of water (i.e. 0.9970 g/ml) [12].…”

Section: Introductionmentioning

confidence: 99%

“…The viscosity of many biopolymer solutions can be easily measured using either rotational type viscometer [6,[8][9][10][13][14][15][16] or capillary type viscometer [17,18]. However, it has been reported that the viscosity of biopolymer solutions is significantly affected by the operating conditions of viscometer (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Surface tension of viscous biopolymer solutions measured using the du Nouy ring method and the drop weight methods

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surface tension of viscous biopolymer solutions measured using the du Nouy ring method and the drop weight methods

et al. 2012

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“…Maximum swelling of these microspheres was noticed at 2-3 hours in phosphate buffer after which, erosion and dissolution took place. It has been previously reported that the swelling of calcium alginate was dependant on the progressive displacement of calcium ions from calcium alginate (Del Gaudio et al, 2005). It was also reported that the swelling might be enhanced by the presence of phosphate ions (in phosphate buffer), which acted as calcium sequestrant Ostberg & Graffner, 1994).…”

Section: Swelling Behaviormentioning

confidence: 98%

Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery:in vitro–in vivoevaluation

Pal¹,

Nayak²

2012

Drug Delivery

147

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Novel tamarind seed polysaccharide (TSP)-alginate mucoadhesive microspheres were prepared using TSP and alginate as blend in different ratios with different calcium chloride (CaCl 2 ) concentration as a cross linker by ionotropic gelation. The prepared microspheres were of spherical shape having rough surfaces, and average particle sizes within the range of 752.12 ± 6.42 to 948.49 ± 20.92 µm. The drug entrapment efficiency of these microspheres were within the range between 58.12 ± 2.42 to 82.78 ± 3.43% w/w. Fourier transform infrared (FTIR) studies indicated that there were no reactions between gliclazide, and polymers (TSP, and sodium alginate) used. Different formulations of gliclazide loaded TSP-alginate microspheres showed prolonged in vitro release profiles of gliclazide over 12 hours in both stomach pH (pH 1.2), and intestinal pH (pH 7.4). It was found that the gliclazide release in gastric pH was comparatively slow and sustained than intestinal pH. These TSP-alginate microspheres also exhibited good mucoadhesivity. The in vivo studies on alloxan-induced diabetic rats (Animal Ethical Committee registration number: IFTM/837ac/0160) demonstrated the significant hypoglycemic effect of selected formulation of TSP-alginate mucoadhesive microspheres containing gliclazide on oral administration. This developed gliclazide loaded new TSPalginate mucoadhesive microspheres may be very much useful for prolonged systemic absorption of gliclazide for proper maintaining blood glucose level and advanced patient compliance.

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“…Disintegration of pellets is a complex phenomenon usually induced by swelling of molecules and modification of surface tension of particles composing each pellet (Del Gaudio, P. Colombo, G. Colombo, Russo, & Sonvico, 2005). Solubilization and diffusion of molecules also occur at the same time.…”

Section: Disintegration In Watermentioning

confidence: 99%

Processing of Fecal Sludge to Fertilizer Pellets Using a Low-Cost Technology in Ghana

Nikiema¹,

Cofie²,

Impraim³

et al. 2013

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This paper describes a study that was aimed at optimizing the pelletization of fecal sludge-based fertilizers for agricultural use. The process developed is easy to implement and increases the marketability of the products while also addressing a serious health and environmental challenge. The study took place during the period 2011-2012 in Ghana. The fecal sludge, rich in nutrients and organic matter, was dried and used to produce five different fertilizers (i.e., four formulations of compost and one with gamma irradiated material). Each material was then pelletized using locally constructed machinery. Key operating parameters, such as moisture content (10-55% in mass), binder type (clay or starch) and concentration (0-10% in mass), were varied and their impacts on the characteristics of pellets (e.g., amount of fine materials generated, length distribution or stability of pellets, and pellet disintegration rate) were also followed. Given the low analyzing capabilities of developing countries, some simple analytical methods were developed and used to compare pellets produced under different conditions. The results confirmed that the addition of 3% of pregelatinized starch is recommended during pelletization of fecal sludge-based fertilizers. Applicable moisture contents were also identified per fertilizer type, and were found to comprise between 21 and 43%.

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Mechanisms of formation and disintegration of alginate beads obtained by prilling

Cited by 132 publications

References 24 publications

Surface tension of viscous biopolymer solutions measured using the du Nouy ring method and the drop weight methods

Surface tension of viscous biopolymer solutions measured using the du Nouy ring method and the drop weight methods

Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery:in vitro–in vivoevaluation

Processing of Fecal Sludge to Fertilizer Pellets Using a Low-Cost Technology in Ghana

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