Mechanisms of exercise response in the denervated heart after transplantation

Hachida, M; Saitou, Satoshi; Nonoyama, M; Hoshi, H; Hanayama, Naoji; Ohkado, Akihiko; Bonkohara, Yukihiro; Koyanagi, Hitoshi

doi:10.1016/s0041-1345(99)00231-6

Cited by 7 publications

(8 citation statements)

References 7 publications

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“…These authors suggest that adrenaline level is a good indicator of the stress level during fl ight and Tarui et al ( 25 ) showed a gradual increase of adrenaline and noradrenaline during repetitive fl ight missions. Moreover, the results of Hachida et al ( 8 ), who demonstrated the ability of the transplanted heart to raise its HR in response to exercise, show that this response is correlated with circulating plasma noradrenaline levels.…”

Section: Discussionmentioning

confidence: 92%

Heart Rate and Autonomic Balance During Stand Tests Before and After Fighter Combat Missions

Dussault¹,

Lely²,

Langrume³

et al. 2009

aviat space environ med

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Section: Discussionmentioning

confidence: 92%

Heart Rate and Autonomic Balance During Stand Tests Before and After Fighter Combat Missions

Dussault¹,

Lely²,

Langrume³

et al. 2009

aviat space environ med

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show abstract

“…A process that occurs since the appearance of the first heartbeat by the 21st day of gestation, and it lasts as long as the blood circulates (24). Blood flow dynamics are more important in controlling heartbeat than the autonomic nervous system which may become useless under certain pathological conditions for example, denervated hearts of cardiac transplant patients (26). Blood flow dynamics are more important in controlling heartbeat than the autonomic nervous system which may become useless under certain pathological conditions for example, denervated hearts of cardiac transplant patients (26).…”

Section: Disadvantages Of Current Cprmentioning

confidence: 99%

“…Loss of myocardial elasticity due to overstretched myocytes could disturb pacemaker cells function inducing variant types of arrhythmias for example, post Mustard arrhythmias (25). Blood flow dynamics are more important in controlling heartbeat than the autonomic nervous system which may become useless under certain pathological conditions for example, denervated hearts of cardiac transplant patients (26).…”

Section: Disadvantages Of Current Cprmentioning

confidence: 99%

Circulatory Flow Restoration Versus Cardiopulmonary Resuscitation: New Therapeutic Approach in Sudden Cardiac Arrest

2017

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Sudden cardiac arrest (SCA) remains a major problem for health authorities worldwide. Insufficiencies of current cardiopulmonary resuscitation (CPR) are most probably related to an inappropriate concept and applied methods that still concentrate on heartbeat as priority, instead of blood circulation to maintain organs' perfusions. The aim of this works is to propose a new therapeutic approach for SCA in a more effective and secure manner compared with current CPR methods. It correlates to a non-invasive circulatory flow restoration (CFR) device composed of a multilayered thoracic and infradiaphragmatic compartments that will be pulsated alternatively and in fixed frequencies using a low-pressure pneumatic generator. Proof-of-concept studies with different prototypes and methods of SCA, showed restoration of hemodynamics (BP ≥ 100 mm Hg) and increased urine output after 20 min of cardiac arrest in pediatric dogs and piglets. In summary, a CFR device can induce shear stress-mediated endothelial function to restore microcirculation and cellular metabolism. This represents a cost-effective method, predisposes to return of spontaneous circulation in case of SCA, adaptable for all age groups, in public and hospital environments.

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“…However, in the cardiac transplant recipient there is a unique environment to consider which results from both afferent (sensory) and efferent (parasympathetic and sympathetic) nerve fiber denervation. Typically, a resting tachycardia exists, coupled with a blunted physiological response to exercise [4]. The benefit of heart rate manipulation in this setting is therefore potentially less clear.…”

Section: Heart Rate Manipulationmentioning

confidence: 99%

“…The benefit of heart rate manipulation in this setting is therefore potentially less clear. It appears that one of the main determinants of heart rate (and in particular heart rate response to exercise) is the elevated concentration of peripherally circulating catecholamines [4]. Therefore, forced manipulation may cause particular problems with exertional symptoms due to chronotropic incompetence.…”

Section: Heart Rate Manipulationmentioning

confidence: 99%

The Usefulness of Chronic Heart Failure Treatments in Chronic Cardiac Graft Failure

Najam

Yonan

Williams

et al. 2010

Cardiovascular Therapeutics

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Following cardiac transplantation, registry data has demonstrated a gradual improvement in survival over the last several decades, which is testament to continual improvement in aftercare strategy. However, a significant number of patients will eventually develop a new syndrome of chronic heart failure, owing to the multitude of physiological processes that occur after transplantation. This condition, referred to as chronic graft failure (CGF) should be regarded as a unique illness rather than one that is simply analogous with chronic heart failure. In particular, the unique pathophysiological (and pharmacological) environment in the setting of CGF presents a challenging situation to the transplant physician. There is uncertainty over which treatments to offer given a paucity of clinical trial data to support the use of standard heart failure treatments in CGF. In this review, we discuss which chronic heart failure treatments could be considered in the setting of CGF based on their mechanisms of action, benefits within the native heart failure setting, and the relevant issues within the posttransplant environment.

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Mechanisms of exercise response in the denervated heart after transplantation

Cited by 7 publications

References 7 publications

Heart Rate and Autonomic Balance During Stand Tests Before and After Fighter Combat Missions

Heart Rate and Autonomic Balance During Stand Tests Before and After Fighter Combat Missions

Circulatory Flow Restoration Versus Cardiopulmonary Resuscitation: New Therapeutic Approach in Sudden Cardiac Arrest

The Usefulness of Chronic Heart Failure Treatments in Chronic Cardiac Graft Failure

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