Mechanisms of ET-1-induced Endothelial Dysfunction

Iglarz, Marc; Clozel, Martine

doi:10.1097/fjc.0b013e31813c6cc3

Cited by 130 publications

(94 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to its vasoconstricting properties, ET-1 has been reported to mediate vessel remodeling by interacting with growth factors and cytokines. Further actions of ET-1 are the promotion of vascular inflammation and excessive oxidative stress (32,33 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison and Evaluation of Cardiac Biomarkers in Patients with Intermittent Claudication: Results from the CAVASIC Study

et al. 2013

View full text Add to dashboard Cite

BACKGROUND Plasma concentrations of the peptides midregional proadrenomedullin (MR-proADM), midregional proatrial natriuretic peptide (MR-proANP), and C-terminal endothelin-1 precursor fragment (CT-proET-1) are increased in various cardiovascular conditions. However, there is limited information about the association and comparative performance of these peptides in peripheral arterial disease (PAD). METHODS The associations of MR-proADM, MR-proANP, and CT-proET-1 plasma concentrations with symptomatic PAD were investigated in the CAVASIC (Cardiovascular Disease in Intermittent Claudication) Study. Study participants were a male cohort of 238 patients with a diagnosis of intermittent claudication (IC) and 245 age- and diabetes-matched controls. Results were compared to those for N-terminal pro-B-type natriuretic peptide (NT-proBNP). RESULTS Each increase of MR-proADM, MR-proANP, and CT-proET-1 by 1 SD was significantly associated with symptomatic PAD: odds ratio (OR) = 1.78 (95% CI, 1.41–2.25, P < 0.001), OR = 1.32 (95% CI, 1.06–1.66, P = 0.014), and OR = 1.80 (95% CI, 1.43–2.28, P < 0.001), respectively. The association remained significant for all 3 markers after additional adjustment for log C-reactive protein, serum creatinine, HDL cholesterol, and current smoking. When one adjusts for log NT-proBNP and excluding individuals with prevalent cardiovascular disease, MR-proADM and CT-proET-1 still predicted symptomatic PAD. Extended adjustment models including MR-proADM or CT-proET-1 showed significantly improved model fits compared to models including classical cardiac risk factors or NT-proBNP and led to significant reclassification (P < 0.05). CONCLUSIONS This study in a male cohort of patients with IC and age- and diabetes-matched controls indicates a significant association of high MR-proADM, MR-proANP, and CT-proET-1 concentrations with PAD. MR-proADM and CT-proET-1 provide additive information in comparison to NT-proBNP. Moreover, MR-proADM and CT-proET-1 significantly predict PAD in those patients and controls free from prevalent CVD.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison and Evaluation of Cardiac Biomarkers in Patients with Intermittent Claudication: Results from the CAVASIC Study

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The over-expression of endothelin-1 can inhibit the activity of endothelial NO synthase, and thereby decreasing NO level and bioavailability [23,24]. When the delicate balance between NO and ET-1 is disturbed, endothelial dysfunction may occur.…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese medicine Tongxinluo stimulates coronary collateral growth in a pig myocardial infarction model

Wang¹,

Ye²,

Cui³

et al. 2017

Hematol Med Oncol

View full text Add to dashboard Cite

Coronary collaterals were reported improving symptoms as well as prognosis for patients with coronary artery disease. This study aimed to investigate whether traditional Chinese medicine Tongxinluo could stimulate coronary collateral growth in a pig acute myocardial infarction (AMI) model. The AMI model was established by surgically ligation of left anterior descending coronary artery (LAD). Twenty-one Chinese Suzhong pigs were randomly divided into two control groups and two treatment groups taking Tongxinluo of 0.36g.kg -1.d -1 and 0.72g.kg -1 .d -1 respectively. Coronary artery angiography (CAG) and left ventriculography were performed to evaluate collaterals and cardiac function 1 month after the treatment, and the density of collateral capillaries of myocardial samples was also counted. The plasma levels of nitric oxide (NO) and endothelin-1 (ET-1) were serially determined. The density of capillaries was significantly higher in both low-dose and high-dose Tongxinluo groups than that in the negative control (P < 0.01) and the positive control groups (P < 0.05). Grade III collateral circulation was found in both treatment groups one month after LAD ligation, and the grades of collateral circulations were positively correlated to the Tongxinluo dosages (P = 0.0191). The cardiac function, the plasma levels of NO and ET-1 showed no significant difference among the treatment and positive control groups. This study demonstrated that Tongxinluo stimulates coronary collateral growth in a pig AMI model.

show abstract

“…1 Endothelial dysfunction is characterized by an imbalance between endotheliumderived contracting factors, including ET-1, angiotensin II and prostaglandin endoperoxides, and endothelium-derived relaxing factors-nitric oxide, prostacyclin (PGI 2 ) and endothelium-derived hyperpolarizing factor, comprising potassium ions, epoxyeicosatrienoic acid, C-type natriuretic peptide, hydrogen peroxide (H 2 O 2 )-responsible for nitric oxide-independent VSCM hyperpolarization and vasorelaxation. [3][4][5] The presence of endothelial dysfunction was confirmed in ageing and in number of diseases, including hypertension, hypercholesterolemia, diabetes, renal failure and congestive heart failure. [3][4][5] As a potent mitogen for glomerular mesangial cells and VSMCs, ET-1 promotes cell growth, migration and proliferation.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] The presence of endothelial dysfunction was confirmed in ageing and in number of diseases, including hypertension, hypercholesterolemia, diabetes, renal failure and congestive heart failure. [3][4][5] As a potent mitogen for glomerular mesangial cells and VSMCs, ET-1 promotes cell growth, migration and proliferation. 1,4,6 Through the activation of mitogen-activated protein kinase, it stimulates cardiomyocyte hypertrophy.…”

Section: Introductionmentioning

confidence: 99%

Carotid atherosclerosis in elderly hypertensive patients: potential role of endothelin and plasma antioxidant capacity

Skalska

Grodzicki

2009

J Hum Hypertens

View full text Add to dashboard Cite

Endothelin-1 (ET-1) and oxidative stress are involved in the development of hypertension-induced cardiovascular complications. The aim of this study was to evaluate the relationship between plasma ET-1 level and plasma antioxidant capacity and carotid atherosclerosis. In 61 treated patients with hypertension (44 women, 35 diabetics, mean age 72.4 ± 7.2 years) medical histories, ambulatory blood pressure, blood tests (glucose, creatinine, cholesterol, haemoglobin A1c (HbA1c), ET-1) and common carotid artery intima-media thickness (CCA-IMT) measurement were carried out. Plasma antioxidant capacity was assessed by the ferric-reducing ability of plasma (FRAP). Subjects with diabetes presented with higher concentrations of glucose (7.01 ± 2.3 vs 5.14±0.6 mmol l À1 , Po0.001), HbA1c (7.75±2.1 vs 6.1±1.2%, Po0.001) and ET-1 (1.36±0.53 vs 1.01± 0.4 pg ml À1 , Po0.01), and lower cholesterol level (5.02±0.8 vs 5.86±1.3 mmol l À1 , Po0.01). A significant positive correlation between CCA-IMT and ET-1 plasma concentration (r ¼ 0.40, Po0.001) and reverse relationship between CCA-IMT and FRAP (r ¼ À0.36, Po0.01) was observed. In a stepwise regression analysis, after adjustment for all confounders, CCA-IMT was independently influenced by age, systolic blood pressure (SBP), HbA1c and ET-1. When FRAP was included in the regression model, CCA-IMT was significantly influenced by age, FRAP, HbA1c and SBP. ET-1 promotes the increase in CCA-IMT contributing to the development of end-organ damage. Plasma antioxidant capacity may modulate this deleterious effect, but whether better antioxidant defence may prevent against the development of atherosclerosis remains to be elucidated.

show abstract

Mechanisms of ET-1-induced Endothelial Dysfunction

Cited by 130 publications

References 102 publications

Comparison and Evaluation of Cardiac Biomarkers in Patients with Intermittent Claudication: Results from the CAVASIC Study

Comparison and Evaluation of Cardiac Biomarkers in Patients with Intermittent Claudication: Results from the CAVASIC Study

Traditional Chinese medicine Tongxinluo stimulates coronary collateral growth in a pig myocardial infarction model

Carotid atherosclerosis in elderly hypertensive patients: potential role of endothelin and plasma antioxidant capacity

Contact Info

Product

Resources

About