Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-α administration differ during wound repair and regeneration

Abarca-Buis, René Fernando; Martínez-Jiménez, Alejandro; Vera-Gómez, Eduardo; Contreras-Figueroa, María Elena; Garciadiego-Cázares, David; Paus, Ralf; Robles‐Tenorio, Arturo; Krötzsch, Edgar

doi:10.1016/j.diff.2017.12.001

Cited by 15 publications

(14 citation statements)

References 44 publications

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“…Mescher's hypothesis relies on experimental studies in different models of regeneration: full-thickness injuries in fetal skin [126], transgenic mouse models deficient for specific immune cells [127], hind-limb amputation in urodeles and anurans [128]. The given evidence suggests that the profile of the infiltrated immune cells and their interactions within the injured tissue directly influences inflammation and scarring [125,129,130].…”

Section: Perspective On the Effect Of The Immune System In The Evolution Of Regenerative Capacitiesmentioning

confidence: 99%

Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages

Mandujano-Tinoco

Sultan

Ottolenghi

et al. 2021

Cells

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The immune system has evolved to protect organisms from infections caused by bacteria, viruses, and parasitic pathogens. In addition, it provides regenerative capacities, tissue maintenance, and self/non-self recognition of foreign tissues. Phagocytosis and cytotoxicity are two prominent cellular immune activities positioned at the base of immune effector function in mammals. Although these immune mechanisms have diversified into a wide heterogeneous repertoire of effector cells, it appears that they share some common cellular and molecular features in all animals, but also some interesting convergent mechanisms. In this review, we will explore the current knowledge about the evolution of phagocytic and cytotoxic immune lineages against pathogens, in the clearance of damaged cells, for regeneration, for histocompatibility recognition, and in killing virally infected cells. To this end, we give different immune examples of multicellular organism models, ranging from the roots of bilateral organisms to chordate invertebrates, comparing to vertebrates’ lineages. In this review, we compare cellular lineage homologies at the cellular and molecular levels. We aim to highlight and discuss the diverse function plasticity within the evolved immune effector cells, and even suggest the costs and benefits that it may imply for organisms with the meaning of greater defense against pathogens but less ability to regenerate damaged tissues and organs.

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Section: Perspective On the Effect Of The Immune System In The Evolution Of Regenerative Capacitiesmentioning

confidence: 99%

Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages

Mandujano-Tinoco

Sultan

Ottolenghi

et al. 2021

Cells

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“…IL‐1 family members are key inflammatory cytokines that generally act synergistically to amplify the inflammatory response. During wound healing, IL‐1 is expressed majorly by neutrophils and macrophages 48 …”

Section: Exudative Phase (Inflammatory/hemostasis Phase)mentioning

confidence: 99%

“…-1 family members are key inflammatory cytokines that generally act synergistically to amplify the inflammatory response.During wound healing, IL-1 is expressed majorly by neutrophils and macrophages 48. Decreased inflammatory cell numbers and reduced epidermal thickness and fibrosis are found in the IL-1R KO mice and wild-type mice treated with IL-1ra 49.…”

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confidence: 99%

The immunologic changes during different phases of intestinal anastomotic healing

zhang

Qiao

et al. 2020

Clinical Laboratory Analysis

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“…This cytokine has two subtypes, IL-1a and IL-1b, and the latter is deeply involved in the pathogenesis of PTOA. [3][4][5] Recent studies have indicated that IL-1 levels in synoviocytes and in the medium supernatant of chondrocytes from patients with PTOA and in mouse models are significantly increased in in vitro experiments, and IL-1b is mainly responsible. 6,7 Attur et al have shown that IL-1b is related to the severity of joint pain and radiological findings in patients with PTOA.…”

Section: Proinflammatory Cytokines Includingmentioning

confidence: 99%

Initial effects of inflammation-related cytokines and signaling pathways on the pathogenesis of post-traumatic osteoarthritis

Han

Zhang

Chen

et al. 2018

Frontiers of Nursing

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The main pathological change in post-traumatic osteoarthritis (PTOA) is cartilage degeneration, which is closely related to inflammation and oxidative stress. Inflammation can cause degeneration of articular cartilage. Cartilage degeneration can also stimulate the progression of inflammation. It has been found that inflammatory cytokines can participate in the pathological process of cartilage degeneration through multiple signaling pathways, mainly mitogen-activated protein kinase, nuclear transcription factor kappa B, and Wnt–β-catenin signal transduction pathways. This review aimed at exploring the relationship between PTOA and inflammation-related cytokines by introducing the role of proinflammatory cytokines in chondrocyte destruction and extracellular matrix degradation.

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Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-α administration differ during wound repair and regeneration

Cited by 15 publications

References 44 publications

Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages

Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages

The immunologic changes during different phases of intestinal anastomotic healing

Initial effects of inflammation-related cytokines and signaling pathways on the pathogenesis of post-traumatic osteoarthritis

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