Mechanisms of enhanced renin secretion during CO2 retention in dogs

Kurz, K D; Zehr, J. E.

doi:10.1152/ajpheart.1978.234.5.h573

Cited by 11 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several investigators reported that renal blood flow decreased during hypercapnia (STONE et al, 1958;BERSENTES and SIMMONS, 1967;NORMAN et al, 1970;FABER et al, 1976;ANDERSON et a!.,1983) and this decrease was attenuated after renal denervation. Other studies showed that hypercapnia decreased urinary sodium excretion (ANDERSON et al, 1982) and increased renin secretion (Fuii Jand ZEHR, 1975;MORITA, 1976;KURTZ and ZEHR, 1978;STASZEWSKA-BARCZAK, 1978). These observations together with our present results suggest that an increase in RNA during hypercapnia might contribute to maintain arterial blood pressure by counteracting the direct vasodilating effect of hypercapnia and by exerting antinatriuretic and antidiuretic actions.…”

Section: Effectssupporting

confidence: 82%

Effects of hypercapnia on renal nerve activity.

Shirahata¹,

Nishino²,

Honda

et al. 1985

Jpn.J.Physiol

View full text Add to dashboard Cite

We investigated the response of renal nerve activity (RNA) to hypercapnia and assessed the contribution of the peripheral chemoreceptors to the response of RNA in anesthetized and artificially ventilated cats. RNA and arterial pressure were recorded at four levels of PETC0, with hyperoxia in intact and in peripheral chemoreceptor denervated cats. In intact cats, RNA increased progressively with increasing PETC02, while no consistent change in arterial pressure was observed. In peripheral chemoreceptor denervated cats, the response of RNA to increasing PETca2 was totally abolished. These results suggest that the peripheral chemoreceptors play an important role in increasing RNA during hypercapnia.

show abstract

Section: Effectssupporting

confidence: 82%

Effects of hypercapnia on renal nerve activity.

Shirahata¹,

Nishino²,

Honda

et al. 1985

Jpn.J.Physiol

View full text Add to dashboard Cite

show abstract

“…These studies were performed because previous experiments indicated that hypercapnic acidosis activates the renin-angiotensin system (Kurz and Zehr, 1978;Anderson et al, 1980) and angiotensin may be antinatriuretic (Johnson and Malvin, 1977). In these animals, both kidneys were innervated.…”

Section: Group 3-hypercapnic Acidosis With Angiotensin II Inhibition mentioning

confidence: 99%

Role of renal nerves, angiotensin II, and prostaglandins in the antinatriuretic response to acute hypercapnic acidosis in the dog.

Henrich

Groß

Dillingham

1982

Circulation Research

View full text Add to dashboard Cite

Although clinical studies suggest that chronic hypercapnic acidosis may be associated with renal sodium retention, little information is available on the effect of acute hypercapnic acidosis on renal sodium excretion. We, therefore, increased Pco 2 from 23 to 74 nun Hg in anesthetized dogs and observed a marked antinatriuresis as absolute sodium excretion (235 to 60 juEq/min, P < 0.001) and fractional excretion of sodium (4.0 to 1.2%, P < 0.02) decreased significantly. This decrease in sodium excretion occurred independent of consistent changes in renal perfusion pressure, Po 2 , glomerular filtration rate, renal blood flow, extraction of p-aminohippuric acid, and filtration fraction. The antinatriuretic response to acute hypercapnic acidosis could be attenuated significantly by surgical renal denervation, intrarenal phenoxybenzamine, and by intrarenal infusion of l-sarcosine,8-glycine angiotensin II. Administration of 10 mg/kg indomethacin enhanced the antinatriuretic response to hypercapnic acidosis in denervated kidneys. These results suggest that renal a-adrenergic nerves and the renin angiotensin system result in an antinatriuretic effect during acute hypercapnic acidosis. Renal prostaglandins or related substances may serve to attenuate this antinatriuretic response.

show abstract

“…Since raising pH in medium without albumin inhibits renin secretion directly, it seems reasonable therefore, to conclude that H ions influence the secretary activity of the juxtaglomerular cells. This direct and specific effect of pH may be an important determinant of renin secretion in vivo, and it may explain the recent, but controversial, evidence concerning the mechanism of enhanced renin secretion during acidosis (Morita, 1976;Kurz & Zehr, 1978;Anderson et al 1980). Changes in extracellular hydrogen ion concentration may induce changes in ionic permeabilities in the juxtaglomerular cells as they do in nerve axon (Strickholm, Wallin & Shrager, 1969) or they may induce changes in Ca binding or Ca movement into the cells as in skeletal muscle (Nakamaru & Schwartz, 1972) and myocardium (Poole-Wilson & Langer, 1979).…”

Section: Discussionmentioning

confidence: 99%

Mechanism by which albumin stimulates renin secretion in isolated kidneys and juxtaglomerular cells.

Fray¹,

Laurens²

1981

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Raising albumin concentration stimulates renin secretion in isolated perfused kidneys and isolated juxtaglomerular cells.2. In isolated perfused kidneys, raising albumin concentration from 20 to 120 g/l. increased renin secretion and perfusate flow when the perfusion medium contained 1-82 mM-total or ionized Ca. Removing the renal capsule abolished the increased flow but not renin secretion.3. In isolated juxtaglomerular cells, raising albumin concentration from 0 to 60 g/l. increased renin secretion threefold. This was enhanced slightly by removing Ca. Raising Ca, removing or raising K to 50 mm, or lowering Na to 25 mm inhibited renin secretion.4. Raising pH from 7-36 to 7-64 inhibited renin secretion whether albumin was present or not. Keeping both pH and ionized Ca constant abolished the stimulatory effect of raising albumin.5. We conclude that raising albumin concentration in plasma may stimulate renin secretion by several mechanisms, two of which are by lowering ionized Ca and lowering pH, and that both effects may be on the juxtaglomerular cells directly. We also conclude that raising pH per se has a powerful inhibitory effect on renin secretion.

show abstract

Mechanisms of enhanced renin secretion during CO2 retention in dogs

Cited by 11 publications

References 0 publications

Effects of hypercapnia on renal nerve activity.

Effects of hypercapnia on renal nerve activity.

Role of renal nerves, angiotensin II, and prostaglandins in the antinatriuretic response to acute hypercapnic acidosis in the dog.

Mechanism by which albumin stimulates renin secretion in isolated kidneys and juxtaglomerular cells.

Contact Info

Product

Resources

About