2002
DOI: 10.1016/s0896-1549(01)00016-5
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Mechanisms of disease: Fuchs' endothelial dystrophy

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Cited by 87 publications
(63 citation statements)
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“…These changes compromise the endothelial pumping function and corneal oedema forms. Oedema spreads anteriorly through the corneal layers as the disease progresses, and eventually, the entire corneal structure becomes swollen with the formation of bullae and painful erosions (Borboli & Colby 2002).…”
Section: Introductionmentioning
confidence: 99%
“…These changes compromise the endothelial pumping function and corneal oedema forms. Oedema spreads anteriorly through the corneal layers as the disease progresses, and eventually, the entire corneal structure becomes swollen with the formation of bullae and painful erosions (Borboli & Colby 2002).…”
Section: Introductionmentioning
confidence: 99%
“…Yet, reports that show ultrastructural signs of "stress" with abundance of degenerated mitochondria, suggest that the mitochondria might be specific targets of oxidant-induced macromolecular damage in susceptible FECD CE cells. 12,13 In this study, we sought to determine whether FECD is associated with oxidant-antioxidant imbalance, and if so, whether oxidant-induced DNA damage (specifically mitochondrial DNA damage) is present in diseased endothelium. We performed antioxidant gene profiling, comparing FECD CE with normal, and detected a decreased antioxidant defense system in FECD.…”
mentioning
confidence: 99%
“…Review of several studies done in North America identified Fuchs' corneal dystrophy as the second most common www.jors.js.iknito.com indication for keratoplasty (15%) ranking second after pseudophakic bullous keratopathy (PBK) (38%) [17][18][19] . Significant proportion of patients with Fuchs dystrophy remain compensated for life and will benefit from cataract surgery to improve their vision, hence the need to minimize further damage on their corneas during cataract surgeries.…”
Section: A Fuchs Corneal Dystrophymentioning
confidence: 99%