Mechanisms of Decreases in Monobromobimane-Derived Fluorescence of Carbamyl Phosphate Synthetase-I Following Hepatotoxic Doses of Acetaminophen in Mice

Abstract

S a r a h K . T a y lor a n d C h a r les V. S m it h D ep a r t m e n t of P e d ia t r ics, Ba ylor C olle ge of M ed icin e, H ou s t on , Te xa s , U S A R ece ived 25 Au g u s t 19 98 ; a cce p t ed 22 O ct ob e r 1 9 9 8 . T h is w or k w a s s u p p or t ed by G M 4 4 2 63 fr om t h e N a t ion a l I n s t it u t es of H e a lt h . Ad d r e s s cor r es p on d en ce t o D r. C h a r les V. S m it h , D e p a r t m en t of P e d ia t r ics, B a ylor C olle ge of M e d icin e, O n e B a y lor P la za , H ou s t on , Texa s 7 7 0 30 , U S A; e -m a il cs m it h @b cm .t m c.ed u Tox ic S u bs t a n ce M e ch a n is m s, 18 :67 ±8 2, 19 99 C op y r igh t