Mechanisms of crosstalk between endocrine systems: Regulation of sex steroid hormone synthesis and action by thyroid hormones

Duarte‐Guterman, Paula; Navarro‐Martín, Laia; Trudeau, Vance L.

doi:10.1016/j.ygcen.2014.03.015

Cited by 139 publications

(82 citation statements)

References 255 publications

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“…Serum T 3 concentrations began to rise in March continuing until early May (pre-spawning period) and substantially fell during spawning. This is consistent with a role for THs in gonadal maturation in fish (Cyr and Eales, 1996;Pavlidis et al, 2000;Duarte-Guterman et al, 2014). Similar declines in TH concentrations during the spawning period were previously found in salmonids (White and Henderson, 1977), flatfishes (Osborn and Simpson, 1978;Eales and Fletcher, 1982), catfishes (Burke and Leatherland, 1983;Biswas et al, 2006), and sparid fish (Pavlidis et al, 2000), but only recently detected in the specious Cyprinidae family (Bolotovskiy and Levin, 2015).…”

Section: Seasonal Changessupporting

confidence: 87%

“…They can both up-regulate, and downregulate gene expression in target tissues or cells (Flamant et al, 2007). In addition, crosstalk between the thyroid axis and other hormonal axes may increase the ability of alterations in the pattern of TH secretion to affect life history traits (Terrien et al, 2011;Flood et al, 2013;Duarte-Guterman et al, 2014).…”

Section: Possible Significance Of T 3 Latitudinal Gradient For Fish Bmentioning

confidence: 99%

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Discovery of latitudinal gradient of triidothyronine concentrations in ectotherms as revealed from a cyprinid fish, the common roach Rutilus rutilus

Левин

Bolotovskiy

2015

Biochemical Systematics and Ecology

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Section: Seasonal Changessupporting

confidence: 87%

Section: Possible Significance Of T 3 Latitudinal Gradient For Fish Bmentioning

confidence: 99%

Discovery of latitudinal gradient of triidothyronine concentrations in ectotherms as revealed from a cyprinid fish, the common roach Rutilus rutilus

Левин

Bolotovskiy

2015

Biochemical Systematics and Ecology

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“…Further investigation is needed to determine if perchlorate affects gonad maturation through direct or indirect pathways, perhaps through interactions between thyroidal and reproductive endocrine systems (Blanton and Specker, 2007; Cyr and Eales, 1996; Duarte-Guterman et al, 2014; Habibi et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Developmental timing of sodium perchlorate exposure alters angiogenesis, thyroid follicle proliferation and sexual maturation in stickleback

Furin¹,

Hippel²,

Postlethwait³

et al. 2015

General and Comparative Endocrinology

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Perchlorate, a common aquatic contaminant, is well known to disrupt homeostasis of the hypothalamus-pituitary-thyroid axis. This study utilizes the threespine stickleback (Gasterosteus aculeatus) fish to determine if perchlorate exposure during certain windows of development has morphological effects on thyroid and gonads. Fish were moved from untreated water to perchlorate-contaminated water (30 and 100 mg/L) starting at 0, 3, 7, 14, 21, 42, 154 and 305 days post fertilization until approximately one year old. A reciprocal treatment (fish in contaminated water switched to untreated water) was conducted on the same schedule. Perchlorate exposure increased angiogenesis and follicle proliferation in thyroid tissue, delayed gonadal maturity, and skewed sex ratios towards males; effects depended on concentration and timing of exposure. This study demonstrates that perchlorate exposure beginning during the first 42 days of development has profound effects on stickleback reproductive and thyroid tissues, and by implication can impact population dynamics. Long-term exposure studies that assess contaminant effects at various stages of development provide novel information to characterize risk to aquatic organisms, to facilitate management of resources, and to determine sensitive developmental windows for further study of underlying mechanisms.

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“…TSH is also responsible for triggering specific developmental processes such as larval metamorphosis in amphibians [2], [3], as well as larval and secondary metamorphoses in some teleost species [4]–[8]. In addition, TSH may participate in the modulation of various functions for example in the immune or reproductive systems, via pleiotropic effects and multiple target tissues of thyroid hormones [9]–[12].…”

Section: Introductionmentioning

confidence: 99%

Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution

et al. 2014

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Thyroid-stimulating hormone (TSH) is composed of a specific β subunit and an α subunit that is shared with the two pituitary gonadotropins. The three β subunits derive from a common ancestral gene through two genome duplications (1R and 2R) that took place before the radiation of vertebrates. Analysis of genomic data from phylogenetically relevant species allowed us to identify an additional Tshβ subunit-related gene that was generated through 2R. This gene, named Tshβ2, present in cartilaginous fish, little skate and elephant shark, and in early lobe-finned fish, coelacanth and lungfish, was lost in ray-finned fish and tetrapods. The absence of a second type of TSH receptor (Tshr) gene in these species suggests that both TSHs act through the same receptor. A novel Tshβ sister gene, named Tshβ3, was generated through the third genomic duplication (3R) that occurred early in the teleost lineage. Tshβ3 is present in most teleost groups but was lostin tedraodontiforms. The 3R also generated a second Tshr, named Tshrb. Interestingly, the new Tshrb was translocated from its original chromosomic position after the emergence of eels and was then maintained in its new position. Tshrb was lost in tetraodontiforms and in ostariophysians including zebrafish although the latter species have two TSHs, suggesting that TSHRb may be dispensable. The tissue distribution of duplicated Tshβs and Tshrs was studied in the European eel. The endocrine thyrotropic function in the eel would be essentially mediated by the classical Tshβ and Tshra, which are mainly expressed in the pituitary and thyroid, respectively. Tshβ3 and Tshrb showed a similar distribution pattern in the brain, pituitary, ovary and adipose tissue, suggesting a possible paracrine/autocrine mode of action in these non-thyroidal tissues. Further studies will be needed to determine the binding specificity of the two receptors and how these two TSH systems are interrelated.

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Mechanisms of crosstalk between endocrine systems: Regulation of sex steroid hormone synthesis and action by thyroid hormones

Cited by 139 publications

References 255 publications

Discovery of latitudinal gradient of triidothyronine concentrations in ectotherms as revealed from a cyprinid fish, the common roach Rutilus rutilus

Discovery of latitudinal gradient of triidothyronine concentrations in ectotherms as revealed from a cyprinid fish, the common roach Rutilus rutilus

Developmental timing of sodium perchlorate exposure alters angiogenesis, thyroid follicle proliferation and sexual maturation in stickleback

Multiple Thyrotropin β-Subunit and Thyrotropin Receptor-Related Genes Arose during Vertebrate Evolution

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