Mechanisms of Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer

Zadorozhna, Mariia; Mangieri, Domenica

doi:10.3390/ijms22126599

Cited by 32 publications

(22 citation statements)

References 101 publications

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“…Zingiber officinale (ginger) is an ancient spice that is normally used as a flavoring agent for food, and it is listed on the Food and Drug Administration (FDA) safe list [106,107]. Ginger and its isolated constituents, such as [6]-gingerol, [6]-paradol, phenolic 1,3-diketones, and zingerone, possess pharmacological properties including anti-bacterial, anti-cancer, antifungal, anti-inflammatory, anti-mutagenic, antioxidant, anti-viral, and immunomodulatory activities, that are associated with its several bioactive compounds, including volatile oil, polyphenols, and flavonoids [108][109][110]. A scientific report revealed the protective effects of ginger extracts against toxicities induced by toxicants [111].…”

Section: Ginger and Cancer Treatmentmentioning

confidence: 99%

Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

Dasari

Njiki

Mbemi

et al. 2022

IJMS

114

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Cisplatin and other platinum-based drugs, such as carboplatin, ormaplatin, and oxaliplatin, have been widely used to treat a multitude of human cancers. However, a considerable proportion of patients often relapse due to drug resistance and/or toxicity to multiple organs including the liver, kidneys, gastrointestinal tract, and the cardiovascular, hematologic, and nervous systems. In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products. Hence, we searched the literature using various scientific databases., such as MEDLINE, PubMed, Google Scholar, and relevant sources, to collect and review relevant publications on cisplatin, natural products, combination therapy, uses in cancer treatment, modes of action, and therapeutic strategies. Our search results revealed that new strategic approaches for cancer treatment, including the combination therapy of cisplatin and natural products, have been evaluated with some degree of success. Scientific evidence from both in vitro and in vivo studies demonstrates that many medicinal plants contain bioactive compounds that are promising candidates for the treatment of human diseases, and therefore represent an excellent source for drug discovery. In preclinical studies, it has been demonstrated that natural products not only enhance the therapeutic activity of cisplatin but also attenuate its chemotherapy-induced toxicity. Many experimental studies have also reported that natural products exert their therapeutic action by triggering apoptosis through modulation of mitogen-activated protein kinase (MAPK) and p53 signal transduction pathways and enhancement of cisplatin chemosensitivity. Furthermore, natural products protect against cisplatin-induced organ toxicity by modulating several gene transcription factors and inducing cell death through apoptosis and/or necrosis. In addition, formulations of cisplatin with polymeric, lipid, inorganic, and carbon-based nano-drug delivery systems have been found to delay drug release, prolong half-life, and reduce systemic toxicity while other formulations, such as nanocapsules, nanogels, and hydrogels, have been reported to enhance cell penetration, target cancer cells, and inhibit tumor progression.

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Section: Ginger and Cancer Treatmentmentioning

confidence: 99%

Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

Dasari

Njiki

Mbemi

et al. 2022

IJMS

114

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“…A more detailed description of ginger effects on the properties of various malignancies types is reviewed in [ 232 , 243 , 244 ].…”

Section: Plants From Different Continents Used In Ethnomedicine For T...mentioning

confidence: 99%

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

et al. 2022

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Traditional herbal medicine (THM) is a “core” from which modern medicine has evolved over time. Besides this, one third of people worldwide have no access to modern medicine and rely only on traditional medicine. To date, drugs of plant origin, or their derivates (paclitaxel, vinblastine, vincristine, vinorelbine, etoposide, camptothecin, topotecan, irinotecan, and omacetaxine), are very important in the therapy of malignancies and they are included in most chemotherapeutic regimes. To date, 391,000 plant and 14,000 mushroom species exist. Their medical and biochemical capabilities have not been studied in detail. In this review, we systematized the information about plants and mushrooms, as well as their active compounds with antitumor properties. Plants and mushrooms are divided based on the regions where they are used in ethnomedicine to treat malignancies. The majority of their active compounds with antineoplastic properties and mechanisms of action are described. Furthermore, on the basis of the available information, we divided them into two priority groups for research and for their potential of use in antitumor therapy. As there are many prerequisites and some examples how THM helps and strengthens modern medicine, finally, we discuss the positive points of THM and the management required to transform and integrate THM into the modern medicine practice.

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“…Ginger has been generally used as a household spice and herbal medicine for a long time [ 22 ]. Ginger extract has a wide range of bioactive phytochemicals, such as gingerol, shogaol, paradols, alkaloids, and flavonoids [ 23 ]. Due to the presence of these phytochemicals, ginger has shown a number of activities such as antimicrobial, anticancer, and anti-inflammatory activities [ 22 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis, Characterization, and Augmented Anticancer Activity of ZrO2 Doped ZnO/rGO Nanocomposite

Ahamed

Lateef

Khan

et al. 2023

JFB

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Fabrication of ZnO nanoparticles (NPs) via green process has received enormous attention for its application in biomedicine. Here, a simple and cost-effective green route is reported for the synthesis of ZrO2-doped ZnO/reduced graphene oxide nanocomposites (ZnO/ZrO2/rGO NCs) exploiting ginger rhizome extract. Our aim was to improve the anticancer performance of ZnO/ZrO2/rGO NCs without toxicity to normal cells. The preparation of pure ZnO NPs, ZnO/ZrO2 NCs, and ZnO/ZrO2/rGO NCs was confirmed by transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), photoluminescence (PL), and dynamic light scattering (DLS). XRD spectra of ZnO/ZrO2/rGO NCs exhibited two distinct sets of diffraction peaks, ZnO wurtzite structure, and ZrO2 phases (monoclinic + tetragonal). The SEM and TEM data show that ZrO2-doped ZnO particles were uniformly distributed on rGO sheets with the excellent quality of lattice fringes without alterations. PL spectra intensity and particle size of ZnO decreased after ZrO2-doping and rGO addition. DLS data demonstrated that green prepared samples show excellent colloidal stability in aqueous suspension. Biological results showed that ZnO/ZrO2/rGO NCs display around 3.5-fold higher anticancer efficacy in human lung cancer (A549) and breast cancer (MCF7) cells than ZnO NPs. A mechanistic approach suggested that the anticancer response of ZnO/ZrO2/rGO NCs was mediated via oxidative stress evident by the induction of the intracellular reactive oxygen species level and the reduction of the glutathione level. Moreover, green prepared nanostructures display good cytocompatibility in normal cell lines; human lung fibroblasts (IMR90) and breast epithelial (MCF10A) cells. However, the cytocompatibility of ZnO/ZrO2/rGO NCs in normal cells was better than those of pure ZnO NPs and ZnO/ZrO2 NCs. Augmented anticancer potential and improved cytocompatibility of ZnO/ZrO2/rGO NCs was due to ginger extract mediated beneficial synergism between ZnO, ZrO2, and rGO. This novel investigation emphasizes the significance of medicinal herb mediated ZnO-based NCs synthesis for biomedical research.

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Mechanisms of Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer

Cited by 32 publications

References 101 publications

Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

Biosynthesis, Characterization, and Augmented Anticancer Activity of ZrO2 Doped ZnO/rGO Nanocomposite

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