Mechanisms of cell death induced by infusion sets leachables in in vitro experimental settings

Kozlovskaya, L.N.; Stepensky, David

doi:10.1016/j.ijpharm.2014.12.020

Cited by 8 publications

(1 citation statement)

References 21 publications

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“…Testing cytotoxicity in real time by administering vancomycin at a variable concentration on cell biochips would avoid the cell stress associated with frequent medium change. On the other hand, a recent study showed that leachable materials released by infusion sets during infusion could induce local cytotoxicity [ 15 ]. Other theories remain to be explored, such as the influence of infusion set materials, in order to optimize methods of administering vancomycin by peripheral intravenous infusion (PIV).…”

Section: Discussionmentioning

confidence: 99%

Disturbance of Vancomycin Infusion Flow during Multidrug Infusion: Influence on Endothelial Cell Toxicity

Drouet¹,

Cuvelier²,

Chai

et al. 2021

Antibiotics

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Background: Phlebitis is a common side effect of vancomycin peripheral intravenous (PIV) infusion. As only one PIV catheter is frequently used to deliver several drugs to hospitalized patients through the same Y-site, perturbation of the infusion flow by hydration or other IV medication may influence vancomycin exposure to endothelial cells and modulate toxicity. Methods: We assessed the toxicity of variations in vancomycin concentration induced by drug mass flow variations in human umbilical vein endothelial cells (HUVECs), simulating a 24 h multi-infusion therapy on the same line. Results were expressed as the percentage of viable cells compared with a 100% control, and the Kruskal–Wallis test was used to assess the toxicity of vancomycin. Results: Our results showed that variations in vancomycin concentration did not significantly influence local toxicity compared to a fixed concentration of vancomycin. Nevertheless, the loss of cell viability induced by mechanical trauma mimicking multidrug infusion could increase the risk of phlebitis. Conclusion: To ensure that vancomycin-induced phlebitis must have other causes than variation in drug mass flow, further in vitro experiments should be performed to limit mechanical stress to frequent culture medium change.

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Section: Discussionmentioning

confidence: 99%

Disturbance of Vancomycin Infusion Flow during Multidrug Infusion: Influence on Endothelial Cell Toxicity

Drouet¹,

Cuvelier²,

Chai

et al. 2021

Antibiotics

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To what extent do the storage conditions of polyether‐based polyurethane have an impact on diazepam delivery?

Maiguy-Foinard

Masse

Degoutin

et al. 2020

J of Applied Polymer Sci

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Interactions between medical device material and the drug itself have been evoked for polyurethane and may lead to underdosing. Polyurethane, sterilization mode, and the crosslinking level of the polymer have an influence on sorption. The aim here is to evaluate the impact of polyurethane conservation time and conditions as well as sterilization mode. Two polyurethane extension tubes were tested, one sterilized by ethylene oxide and the second by gamma radiation. Forced degradation experiments were performed. After 3 and 6 months of incubation, thermal properties, diazepam delivery and cytotoxicity of leachates were assessed. Diazepam delivery differs significantly according to the version of polyurethane. Sterilization however has no impact on diazepam delivery. No cytotoxicity was observed whatever the infusion tube and the aging conditions. In conclusion, sterilization procedures do not induce polyurethane degradation, but high temperature/relative humidity/time storage conditions lead to a slight degradation in polyurethane.

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Potential application of natural rubber latex nanoparticles to tissue engineering

Okamoto

2021

Chemistry, Manufacture, and Applications of Natural Rubber

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Mechanisms of cell death induced by infusion sets leachables in in vitro experimental settings

Cited by 8 publications

References 21 publications

Disturbance of Vancomycin Infusion Flow during Multidrug Infusion: Influence on Endothelial Cell Toxicity

Disturbance of Vancomycin Infusion Flow during Multidrug Infusion: Influence on Endothelial Cell Toxicity

To what extent do the storage conditions of polyether‐based polyurethane have an impact on diazepam delivery?

Potential application of natural rubber latex nanoparticles to tissue engineering

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