Mechanisms of blood-retinal barrier disruption related to intraocular inflammation and malignancy

Tomkins-Netzer, Oren; Niederer, Rachael; Greenwood, John; Fabian, Ido Didi; Serlin, Yonatan; Friedman, Alon; Lightman, Sue

doi:10.1016/j.preteyeres.2024.101245

Cited by 1 publication

(1 citation statement)

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“…Arteries originate from the carotid arteries, and the central retinal artery is an essential thing from ophthalmic arteries. The supply blood layer part in the retina originates from the central retinal artery And its branches (Tomkins-Netzer et al, 2024). In normal conditions, the blood supply to 2/3 of the parts of the retina is supplied from a central retinal artery, and 1/3 of the part is supplied outside of the circulation choroidal through diffusion.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness Therapy Oxygen Hyperbaric (HBOT) Against Central Retinal Artery Occlusion (CRAO): Literature Review

Wandini

2024

ijsh

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Central Retinal Artery Occlusion (CRAO) is a rare eye disease causing sudden vision loss due to artery blockage. It's considered an eye emergency due to potential ischemia, infarction, and acute vision loss. Hyperbaric oxygen therapy (HBOT), delivering 100% oxygen at pressures exceeding 1 atmosphere, enhances oxygen transport, vascular perfusion, and neuroprotection, benefiting retinal tissue. Under hyperbaric conditions, oxygen supply to the retina increases to 100%, reducing edema and preserving adjacent tissue. This research method uses a literature review design. Three articles were included in the international database PubMed. The results of the review revealed that the three articles analyzed in the literature reported a consistent finding: hyperbaric oxygen therapy (HBOT) has the potential to reduce macular edema. This suggests that HBOT may offer a promising treatment modality for addressing macular edema associated with Central Retinal Artery Occlusion (CRAO). In the discussion, it can be inferred that the mechanism behind HBOT's efficacy in reducing macular edema lies in its ability to enhance oxygen delivery to the ischemic retina, thereby reducing edema and preserving surrounding tissue. This finding underscores the importance of exploring HBOT as a therapeutic option for managing complications of CRAO, potentially improving visual outcomes for affected individuals. However, further clinical studies are warranted to validate these findings and elucidate the optimal HBOT protocols for treating macular edema in CRAO patients. The thickness of the retinal layer in patients progressively decreased, compared to the accompanying eye in reducing edema.

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Section: Introductionmentioning

confidence: 99%