1957
DOI: 10.1001/archderm.1957.01550230050008
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Mechanisms of Blister Formation

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Cited by 41 publications
(11 citation statements)
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“…It is a matter of debate whether KIF alterations in response to pemphigus autoantibodies are secondary to changes of the desmosomes or rather cause and contribute to altered desmosome composition and turnover. Indeed, in early ultrastructural studies, it was suggested that the initial changes affect KIFs ( 20 , 28 ). We here demonstrated that changes of the KIF cytoskeleton are visible in HaCaT keratinocytes starting at 60 min after application of autoantibodies.…”
Section: Discussionmentioning
confidence: 99%
“…It is a matter of debate whether KIF alterations in response to pemphigus autoantibodies are secondary to changes of the desmosomes or rather cause and contribute to altered desmosome composition and turnover. Indeed, in early ultrastructural studies, it was suggested that the initial changes affect KIFs ( 20 , 28 ). We here demonstrated that changes of the KIF cytoskeleton are visible in HaCaT keratinocytes starting at 60 min after application of autoantibodies.…”
Section: Discussionmentioning
confidence: 99%
“…He likewise theo rizes th a t injurv to epidermal cells from multiple diverse etiologic agents results in an enzym atic degradation process which in turn elicits the vesicle or blister. This author [24] also states th at the presence of a basem ent m em brane at the dermal-epidermal junction is now an established fact and th a t this membrane is an amorphous structure consisting prim arily of mucopolysaccharides which are closely related to if not identical to the ground substance of the der mis. The basem ent m em brane exists normally in a " gel" state and is probably capable of reversible transformation into a " sol" state.…”
Section: Theories Relative To the Blister Formationmentioning
confidence: 97%
“…More recently, Cottini [22] emphasizes the im portance of enzym atic alterations in causation of bullae. Stoughton [23] includes vascular occlusion as a cause of bullae in the various skin disorders characterized by blister formation. He likewise theo rizes th a t injurv to epidermal cells from multiple diverse etiologic agents results in an enzym atic degradation process which in turn elicits the vesicle or blister.…”
Section: Theories Relative To the Blister Formationmentioning
confidence: 99%
“…Excessive static normal stress has been shown to cause blood flow occlusion (Daly et al, 1976) which can result in necrosis and ulceration (Levy, 1962). Trauma from dynamic All correspondence to be addressed to J. E. Sanders Ph.D., Center for Bioengineering, WD-12, University of Washington, Seattle, Washington 98195, USA. shear is apparent as separation at the dermalepidermal junction, followed by fluid deposition and blister formation (Stoughton, 1957;Hunter et al, 1974).…”
Section: Introductionmentioning
confidence: 99%