Mechanisms of Arsenic-Induced Toxicity with Special Emphasis on Arsenic-Binding Proteins

Hussain, Afaq; Raveendran, Vineeth Andisseryparambil; SoumyaKundu,; Samanta, Tapendu; Shunmugam, Raja; Pal, Debnath; Sarma, Jayasri Das

doi:10.5772/intechopen.74758

Cited by 8 publications

(6 citation statements)

References 67 publications

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“…As binding to plant cells may lead to protein folding or conformational changes. The proteins that bind to As are transcription factors, signalling proteins, metabolic enzymes, and certain structural proteins (Hussain et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Heavy metal induced regulation of plant biology: Recent insights

Sharma

Kapoor

Gautam

et al. 2022

Physiologia Plantarum

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The presence of different forms of heavy metals in the earth crust is very primitive and probably associated with the origin of plant life. However, since the beginning of human civilisation, heavy metal use and its contamination to all living systems on earth have significantly increased due to human anthropogenic activities. Heavy metals are nonbiodegradable, which directly or indirectly impact photosynthesis, antioxidant system, mineral nutrition status, phytohormones and amino acid‐derived molecules. Due to the toxic behaviour of some heavy metals, the endogenous status of chemical messengers like phytohormones may get significantly influenced, leading to harmful impacts on plant growth, development and overall yield of the plants. It has been noticed that exogenous application of phytohormones, that is, abscisic acid, salicylic acid, auxins, brassinosteroids, cytokinins, ethylene and gibberellins can positively regulate the heavy metal toxicity in plants through the regulation of the ascorbate–glutathione cycle, nitrogen metabolism, proline metabolisms, transpiration rate, and cell division. Furthermore, it may also restrict the entry of heavy metals into the plant cells, which aids in the recovery of plant growth and productivity. Besides these, some defence molecules also assist the plant in dealing with heavy metal toxicity. Therefore, the present review aims to bridge the knowledge gap in this context and present outstanding discoveries related to plant life supportive processes during stressful conditions including phytohormones and heavy metal crosstalk along with suggestions for future research in this field.

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Section: Introductionmentioning

confidence: 99%

Heavy metal induced regulation of plant biology: Recent insights

Sharma

Kapoor

Gautam

et al. 2022

Physiologia Plantarum

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“…Cheng et al found a relation between exposure to arsenic and chronic kidney disease in Taiwan [9]. According to recent reports the arsenite toxicity is due to its interaction to cysteine residues in proteins [10].…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Aqueous As (III) in Presence of Coexisting Ions by a Green Fe-Modified W Zeolite

Medina-Ramírez

Gamero‐Melo²,

Ruiz-Camacho

et al. 2019

Water

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The high toxicity of arsenite and the difficulty to remove it is one of the main challenges for water treatment. In the present work the surface of a low cost zeolite was modified by chemical treatment with a ferrous chloride to enhance its arsenite adsorption capacity. The effect of pH, ions coexistence, concentration, temperature and dosage was studied on the adsorption process. Additionally, the Fe-modified W zeolite was aged by an accelerated procedure and the regeneration of the exhausted zeolite was demonstrated. The Fe-modified W zeolite was stable in the pH range of 3 to 8 and no detriment to its arsenite removal capacity was observed in the presence of coexisting ions commonly found in underground water. The studies showed that the adsorption of As (III) on Fe-modified W zeolite is a feasible, spontaneous and endothermic process and it takes place by chemical bonding. The exhausting process proved the adsorption of 0.20 mg g−1 of As (III) by the Fe-modified W zeolite and this withstand at least five aging cycles without significant changes of its arsenite adsorption capacity. Fe-modified W zeolite prepared from fly ash might be a green and low-cost alternative for removal of As (III) from groundwater.

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“…It could be deduced that the bioactive compounds such as benzofuran 2,3 dihydro, hexadecaboic acid, cis-vaccenic acid and oleic acid present in the C. afer leaves hexane fraction might be responsible for the hepatoprotective effect [21]. Molecularly, arsenite is known to induce tissue toxicity through generation of oxidative stressors and cellular signals that result into the binding of arsenite to thiol groups of macromolecules with the subsequent propa gation of deleterious chemical species and apoptosis [28,29]. C. afer hexane leaf fraction has been shown to possess antioxidant and antiinflammatory property against reactive oxygen species (ROS) and proinflammatory mediators [19].…”

Section: Resultsmentioning

confidence: 99%

Protective effects of hexane fraction of Costus afer leaves against sodium arsenite-induced hepatotoxicity and nephrotoxicity in male albino wistar rats

Anyasor¹,

Aramide²,

Shokunbi³

2020

Ukr.Biochem.J

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Arsenite is a toxic metallic pollutant known to cause hepatotoxic and nephrotoxic injuries. Costus afer ker Gawl is an indigenous medicinal plant used as therapy for numerous tissue disorders. Thus, this study investigated the protective potential of C. afer hexane leaf fraction (CALhF) on sodium arsenite-induced hepatic and renal injuries in albino rats. Twenty-five male albino rats were randomly divided into five groups of five rats each. Group 1: rats administered orally with 0.5 ml of 0.9% saline; Group 2: untreated rats with induced toxicity by 5 mg/kg body weight (b.w.) sodium arsenite (i.p.); Group 3: rats with sodium arseniteinduced toxicity and treated with 10 mg/kg b.w. silymarin (hepatoprotective drug); Group 4 and 5: rats with sodium arsenite-induced toxicity and treated with 100 and 200 mg/kg b.w. CALHF, respectively. CALHF was orally administered daily, while sodium arsenite was administered every 48 hours for 14 days. Thereafter, rats were sacrificed, blood was collected to estimate hepatic and nephrotic functions. Hepatic and renal function tests showed that 100 and 200 mg/kg CALHF and 10 mg/kg silymarin treated animals had significantly reduced (p < 0.05) plasma alanine aminotransferase, aspartate aminotransferase, creatinine and urea levels, when compared with those of untreated animals. C. afer hexane leaf fraction exhibited hepatoprotective and nephroprotective effects against sodium arsenite induced toxicity in rats.

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Mechanisms of Arsenic-Induced Toxicity with Special Emphasis on Arsenic-Binding Proteins

Cited by 8 publications

References 67 publications

Heavy metal induced regulation of plant biology: Recent insights

Heavy metal induced regulation of plant biology: Recent insights

Adsorption of Aqueous As (III) in Presence of Coexisting Ions by a Green Fe-Modified W Zeolite

Protective effects of hexane fraction of Costus afer leaves against sodium arsenite-induced hepatotoxicity and nephrotoxicity in male albino wistar rats

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