Mechanisms of altered Ca2+ turnover in type 2 diabetes

Balasubramanyam, M; Balaji, R.; Subashini, Balakrishnan; Mohan, V.

doi:10.1016/s0168-8227(00)82003-3

Cited by 1 publication

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“…When PPAR-γ is bound with a ligand or some kind of synthetic compound, such as thiazolidinedione, the whole structure becomes active and complex with another transcription factor retinoid X-receptor (RXR). The heterodimer complex PPAR-γ -RXR is then bound to a specific DNA motif, which is known as peroxisome proliferate response element (PPREs) in the promoters of target gene [23]. This then leads to the activation of regulation.…”

Section: Peroxisome Proliferator-activated Receptor (Ppar-γ )mentioning

confidence: 99%

Targeted proteins for diabetes drug design

Nguyen

2012

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Type 2 diabetes mellitus is a common metabolism disorder characterized by high glucose in the bloodstream, especially in the case of insulin resistance and relative insulin deficiency. Nowadays, it is very common in middle-aged people and involves such dangerous symptoms as increasing risk of stroke, obesity and heart failure. In Vietnam, besides the common treatment of insulin injection, some herbal medication is used but no unified optimum remedy for the disease yet exists and there is no production of antidiabetic drugs in the domestic market yet. In the development of nanomedicine at the present time, drug design is considered as an innovative tool for researchers to study the mechanisms of diseases at the molecular level. The aim of this article is to review some common protein targets involved in type 2 diabetes, offering a new idea for designing new drug candidates to produce antidiabetic drugs against type 2 diabetes for Vietnamese people.

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Section: Peroxisome Proliferator-activated Receptor (Ppar-γ )mentioning

confidence: 99%

Targeted proteins for diabetes drug design

Nguyen

2012

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Mechanisms of altered Ca2+ turnover in type 2 diabetes

Cited by 1 publication

References 0 publications

Targeted proteins for diabetes drug design

Targeted proteins for diabetes drug design

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