Mechanisms of Altered Airway Mechanics Following Acute Cigarette Smoke Inhalation in Rabbits.

Bayat, Sam; Porra, Liisa; Peták, Ferenc; Jánosi, Tibor Z.; Bertrand, D.; Sovijärvi, Anssi; Suortti, P.; Suhonen, Heikki; Strengell, Satu; Neitola, Kimmo; Sipilä, Markku; Laakso, Lauri; Hantos, Zoltán; Habre, Walid

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2439

Cited by 4 publications

(4 citation statements)

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“…The continuous search for finding new imaging-based techniques to obtain regional lung function and biomechanics data led to employing synchrotron radiation sources to produce highly coherent, high flux x-rays that are required for phase contrast x-ray imaging (PCXI) [see (Bayat et al, 2001), (Bayat et al, 2009), (Porra et al, 2004), (Monfraix et al, 2004), (Bayat et al, 2022a), , (Bayat et al, 2022b)]. PCXI is a high-resolution imaging technique, capable of differentiating between soft tissues by enhancing the contrast of biological interfaces and also providing dynamic motions of lung tissue.…”

Section: Phase Contrast X-ray Lung Functionmentioning

confidence: 99%

Imaging and Functional Imaging of the Lung

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Phase Contrast X-ray Lung Functionmentioning

confidence: 99%

Imaging and Functional Imaging of the Lung

2024

Frontiers Research Topics

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“…The continuous search for finding new imaging-based techniques to obtain regional lung function and biomechanics data led to employing synchrotron radiation sources to produce highly coherent, high flux x-rays that are required for phase contrast x-ray imaging (PCXI) [see (Bayat et al, 2001), (Bayat et al, 2009), (Porra et al, 2004), (Monfraix et al, 2004), (Bayat et al, 2022a), (Cercos-Pita et al, 2022), (Bayat et al, 2022b)]. PCXI is a high-resolution imaging technique, capable of differentiating between soft tissues by enhancing the contrast of biological interfaces and also providing dynamic motions of lung tissue.…”

Section: Phase Contrast X-ray Lung Functionmentioning

confidence: 99%

Lung function measurements in preclinical research: What has been done and where is it headed?

2023

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Due to the close interaction of lung morphology and functions, repeatable measurements of pulmonary function during longitudinal studies on lung pathophysiology and treatment efficacy have been a great area of interest for lung researchers. Spirometry, as a simple and quick procedure that depends on the maximal inspiration of the patient, is the most common lung function test in clinics that measures lung volumes against time. Similarly, in the preclinical area, plethysmography techniques offer lung functional parameters related to lung volumes. In the past few decades, many innovative techniques have been introduced for in vivo lung function measurements, while each one of these techniques has their own advantages and disadvantages. Before each experiment, depending on the sensitivity of the required pulmonary functional parameters, it should be decided whether an invasive or non-invasive approach is desired. On one hand, invasive techniques offer sensitive and specific readouts related to lung mechanics in anesthetized and tracheotomized animals at endpoints. On the other hand, non-invasive techniques allow repeatable lung function measurements in conscious, free-breathing animals with readouts related to the lung volumes. The biggest disadvantage of these standard techniques for lung function measurements is considering the lung as a single unit and providing only global readouts. However, recent advances in lung imaging modalities such as x-ray computed tomography and magnetic resonance imaging opened new doors toward obtaining both anatomical and functional information from the same scan session, without the requirement for any extra pulmonary functional measurements, in more regional and non-invasive manners. Consequently, a new field of study called pulmonary functional imaging was born which focuses on introducing new techniques for regional quantification of lung function non-invasively using imaging-based techniques. This narrative review provides first an overview of both invasive and non-invasive conventional methods for lung function measurements, mostly focused on small animals for preclinical research, including discussions about their advantages and disadvantages. Then, we focus on those newly developed, non-invasive, imaging-based techniques that can provide either global or regional lung functional readouts at multiple time-points.

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“…An advantage of this technique is that both structural images and elemental distribution maps, which allow functional parameters to be measured, can be obtained simultaneously using the same imaging modality. The KES-CT imaging technique has previously been used to measure regional lung ventilation during stable xenon gas inhalation (Bayat et al, 2001(Bayat et al, , 2006(Bayat et al, , 2009Porra et al, 2004Porra et al, , 2010Strengell et al, 2013), and to measure regional blood volume distribution during steady-state iodine infusion (Suhonen et al, 2008) in rabbit. This technique is promising for the early diagnosis of focal changes in regional lung function, at early stages of diseases such as asthma, chronic obstructive pulmonary disease (COPD) or cystic fibrosis, that routine measurements of global lung function and gas exchange are unable to detect.…”

Section: Introductionmentioning

confidence: 99%

Radiation dose and image quality inK-edge subtraction computed tomography of lungin vivo

Strengell

Keyriläinen

Suortti

et al. 2014

J Synchrotron Radiat

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K-edge subtraction computed tomography (KES-CT) allows simultaneous imaging of both structural features and regional distribution of contrast elements inside an organ. Using this technique, regional lung ventilation and blood volume distributions can be measured experimentally in vivo. In order for this imaging technology to be applicable in humans, it is crucial to minimize exposure to ionizing radiation with little compromise in image quality. The goal of this study was to assess the changes in signal-to-noise ratio (SNR) of KES-CT lung images as a function of radiation dose. The experiments were performed in anesthetized and ventilated rabbits using inhaled xenon gas in O2 at two concentrations: 20% and 70%. Radiation dose, defined as air kerma (Ka), was measured free-in-air and in a 16 cm polymethyl methacrylate phantom with a cylindrical ionization chamber. The dose free-in-air was varied from 2.7 mGy to 8.0 Gy. SNR in the images of xenon in air spaces was above the Rose criterion (SNR > 5) when Ka was over 400 mGy with 20% xenon, and over 40 mGy with 70% xenon. Although in human thorax attenuation is higher, based on these findings it is estimated that, by optimizing the imaging sequence and reconstruction algorithms, the radiation dose could be further reduced to clinically acceptable levels.

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Mechanisms of Altered Airway Mechanics Following Acute Cigarette Smoke Inhalation in Rabbits.

Cited by 4 publications

References 0 publications

Imaging and Functional Imaging of the Lung

Imaging and Functional Imaging of the Lung

Lung function measurements in preclinical research: What has been done and where is it headed?

Radiation dose and image quality inK-edge subtraction computed tomography of lungin vivo

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