Mechanisms of action of fluoridated acidic liquid dentifrices against dental caries

Cardoso, Cristiane de Almeida Baldini; Lacerda, Bianca; Mangueira, Dayane Franco Barros; Charone, Senda; Olympio, Kelly Polido Kaneshiro; Magalhães, Ana Carolina; Pessan, Juliano Pelim; Vilhena, Fabiano Vieira; Sampaio, Fábio Correia; Buzalaf, Marília Afonso Rabelo

doi:10.1016/j.archoralbio.2014.08.016

Cited by 19 publications

(11 citation statements)

References 32 publications

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“…The effects of fluoride on the prevention of tooth decay and re-mineralization of decalcified enamel have been elaborately described. [ 21 22 23 24 ]…”

Section: Discussionmentioning

confidence: 99%

Timing considerations on the shear bond strength of orthodontic brackets after topical fluoride varnish applications

et al. 2017

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Objectives:To assess the best temporal association between the application of a fluoride varnish on enamel and bonding procedures.Materials and Methods:Eighty mandibular bovine incisors were used. Teeth were divided into 4 groups (20 per group); Groups 1–3 were treated with fluoride varnish (Fluor Protector, Ivoclar Vivadent, Schaan, Liechtenstein), and Group 4 served as control with no pretreatment. Tooth were stored in deionized water (37°C) and subjected to thermal cycling for 400 (Group 1), 800 (Group 2), and 2500 (Group 3) cycles corresponding, respectively, to 15, 30, and 90 days in order to simulate the three different timing of bracket bonding. Shear bond strength (SBS) was measured using an Instron Universal Testing machine. Tooth surfaces were examined under a stereomicroscope at 10× magnification to assess the amount of adhesive remnant index (ARI). One-way analysis of variance (ANOVA) and Tukey's honestly significant difference post-hoc test were used for the comparison of SBS values between groups (P < 0.05). The Chi-square test was used to examine differences among ARI scores. (P < 0.05).Results:One-way ANOVA and Tukey post-hoc test showed that the SBS of different groups were significantly different and was impacted by different timing of bonding (P < 0.05). The main differences were between the control group (17.02 ± 6.38 MPa) and Group 1 (6.93 ± 4.3 MPa). The ARI scores showed that there were no significant differences between the four tested groups.Conclusions:The SBS of the brackets bonded 15 days after the application of the fluoride was set back to an optimal value.

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“…The effects of fluoride on the prevention of tooth decay and re-mineralization of decalcified enamel have been elaborately described. [ 21 22 23 24 ]…”

Section: Discussionmentioning

confidence: 99%

Timing considerations on the shear bond strength of orthodontic brackets after topical fluoride varnish applications

et al. 2017

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“…One of the main reasons for enamel demineralization is undoubtedly a decrease in pH below the critical point that leads to the dissolution of hydroxylapatite 14 . It is well documented that fluoride compounds have been widely used to decrease the development or progression of caries because of its ability to promote remineralization, and reduce the rate of demineralization of teeth 7 , 26 .…”

Section: Discussionmentioning

confidence: 99%

“…Even with the emergence of new preventive measures, fluoride is still considered one of the most prominent elements because it not only has chemical qualities but physiological properties as well, and is of great interest and importance to the dentist 7 . Despite its benefits, excess fluoride can be toxic.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of plant-derived proanthocyanidins on demineralization on enamel and dentin under artificial cariogenic challenge

et al. 2015

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Dental caries is considered a disease of high prevalence and a constant problem in public health. Proanthocyanidins (PAs) are substances that have been the target of recent studies aiming to control or treat caries. Objective The aim of this in vitro study was to evaluate the efficacy of a treatment with grape seed extract, under cariogenic challenge, to minimize or even prevent the onset of caries in the enamel and dentin.Material and Methods Blocks of enamel and dentin (6.0x6.0 mm) were obtained from bovine central incisors, polished, and selected by analysis of surface microhardness (SH). The blocks were randomly divided into 3 groups (n=15), according to the following treatments: GC (control), GSE (grape seed extract), GF (fluoride – 1,000 ppm). The blocks were subjected to 6 daily pH cycles for 8 days. Within the daily cycling, the specimens were stored in buffered solution. The blocks were then analyzed for perpendicular and surface hardness and polarized light microscopy.Results The means were subjected to statistical analysis using the ANOVA and Fisher’s PLSD tests (p<0.05). For enamel SH, GF showed the highest hardness values. In the dentin, GF was also the one that showed higher hardness values, followed by GSE. Regarding the cross-sectional hardness values, all groups behaved similarly in both the enamel and dentin. The samples that were treated with GSE and fluoride (GF) showed statistically higher values than the control.Conclusion Based on the data obtained in this in vitro study, it is suggested that grape seed extract inhibits demineralization of artificial carious lesions in both the enamel and dentin, but in a different scale in each structure and in a smaller scale when compared to fluoride.

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“…35 It has also been suggested to have the potential to enhance caries protection from toothpastes. 36,37 A further formulation change was the inclusion of the carboxylic acid copolymer PVM/MA. Such materials have potential for multi-point attachment of the polymer chains to cationic sites on enamel surfaces and have been shown by in vitro studies to enhance resistance to demineralisation, presumably by a surfacestabilising mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…It has been known for many years that a limited lowering of the pH of fluoride treatments 34 increases fluoride uptake to enamel without leading to demineralisation 35 . It has also been suggested to have the potential to enhance caries protection from toothpastes 36,37 . A further formulation change was the inclusion of the carboxylic acid copolymer PVM/MA.…”

Section: Discussionmentioning

confidence: 99%

The effect of dentifrice ingredients on enamel erosion prevention and repair

Fowler

Creeth

Paul

et al. 2021

Surface & Interface Analysis

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Fluoride is a key dentifrice ingredient for mitigating dental erosion and promoting remineralisation in tooth enamel. A dentifrice formulation (NaF/CL ‐ where C = Copolymer, L = Lactate), optimised for fluoride delivery, containing sodium fluoride, polyvinylmethylether–maleic anhydride (PVM/MA) copolymer and lactate ion at controlled pH of 6.2 is compared with six commercial dentifrices from European and US regulatory regions. The in vitro study utilised white light interferometry (WLI) and dynamic secondary ion mass spectrometry (DSIMS) to assess dental erosion resistance and remineralisation potential of the dentifrices. For WLI, polished enamel samples were immersed in dentifrice slurry (1:3 wt./wt. in artificial saliva, 2 min), brushed, washed in deionised water, acid challenged (1% citric acid, pH 3.8, 5 min), washed and air dried. Surface roughness and bulk tissue loss were measured. DSIMS samples for fluoride uptake were acid challenged (1% citric acid, pH 3.8, 5 min), rinsed, immersed in dentifrice slurry (1:3 wt./wt. in artificial saliva, 2 min), washed and air dried. DSIMS samples for 44Ca uptake were prepared similarly but with 44Ca‐doped artificial saliva. The NaF/CL dentifrice provided highest protection against dental erosion, with highest fluoride and 44Ca uptake in all treatment groups (n = 5 per group). Dentifrices containing other fluoride salts and/or ingredients known to inhibit fluoride uptake (e.g., polyphosphates, sodium lauryl sulfate), performed significantly worse.

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Mechanisms of action of fluoridated acidic liquid dentifrices against dental caries

Cited by 19 publications

References 32 publications

Timing considerations on the shear bond strength of orthodontic brackets after topical fluoride varnish applications

Timing considerations on the shear bond strength of orthodontic brackets after topical fluoride varnish applications

Effectiveness of plant-derived proanthocyanidins on demineralization on enamel and dentin under artificial cariogenic challenge

The effect of dentifrice ingredients on enamel erosion prevention and repair

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