Mechanisms of action for aryl hydrocarbon receptor ligands in the PLHC-1 cell line

Hestermann, Eli V.

doi:10.1575/1912/4097

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Cited by 3 publications

(2 citation statements)

References 143 publications

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“…This relationship does not hold for EC50s for EROD induction, where the slope of the line is significantly less than 1. This is in agreement with our previous results for a more limited set of compounds showing that EC50s based on EROD induction overestimate relative potencies compared to CYP1A protein induction in the same cells Hestermann et…”

Section: Resultssupporting

confidence: 93%

See 1 more Smart Citation

Relative Contributions of Affinity and Intrinsic Efficacy to Aryl Hydrocarbon Receptor Ligand Potency

Hestermann

Stegeman

Hahn

2000

Toxicology and Applied Pharmacology

Self Cite

166

103

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Section: Resultssupporting

confidence: 93%

“…These cells express a single CYP1A isoform, which has no detectable constitutive expression . These cells also express only one AHR, an AHR2 form (Hahn, 1998;Hestermann, 1999). For EROD and CYP1A ELISA assays, cells were seeded into 96-well plates (Costar, Cambridge, MA) at 2 X 10 5 cells in 0.2 ml cu,lture medium per well.…”

Section: Chemicalsmentioning

confidence: 99%