Abstract:Several studies have indicated that Diabetes Mellitus (DM) can increase the risk
of developing Alzheimer's disease (AD). This review briefly describes current
concepts in mechanisms linking DM and insulin resistance/deficiency to AD.
Insulin/insulin-like growth factor (IGF) resistance can contribute to
neurodegeneration by several mechanisms which involve: energy and metabolism
deficits, impairment of Glucose transporter-4 function, oxidative and
endoplasmic reticulum stress, mitochondrial dysfunction, accumul…
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