Mechanisms linking bariatric surgery to adipose tissue, glucose metabolism, fatty liver disease and gut microbiota

Abstract

Purpose In the last 20 years, bariatric surgery has achieved an important role in translational and clinical research because of obesity comorbidities. Initially, a tool to lose weight, bariatric surgery now has been shown to be involved in several metabolic pathways. Methods We conducted a narrative review discussing the underlying mechanisms that could explain the impact of bariatric surgery and the relationship between obesity and adipose tissue, T2D, gut microbiota, and NAFLD. Results Bariatric surgery has an impact in the relation between obesity and type 2 diabetes, but in addition it induces the white-to-brown adipocyte trans-differentiation, by enhancing thermogenesis. Another issue is the connection of bariatric surgery with the gut microbiota and its role in the complex mechanism underlying weight gain. Conclusion Bariatric surgery modifies gut microbiota, and these modifications influence lipid metabolism, leading to improvement of non-alcoholic fatty liver disease.

Circulating Sphingolipids and Glucose Homeostasis: An Update

“…Finally, circulating concentrations of ceramides have been shown to predict the durability of T2D remission after bariatric surgery [46,47]. Furthermore, gut microbiota, key players in long-term glucose metabolism improvement after bariatric surgery [130], have been shown to regulate circulating ceramides [131]. One could therefore ask the question of the role of ceramides in this process.…”