Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis

Zhang, Wei; Dai, Sheng‐Ming

doi:10.1016/j.intimp.2012.06.001

Cited by 128 publications

(79 citation statements)

References 28 publications

(68 reference statements)

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“…1 Paeoniae Radix has been used to treat amenorrhea, dysmenorrhea, inflammation, and spasm. 2,3 This crude drug is well known to stimulate blood circulation and exhibit anti-inflammatory, antiplatelet, and vasodilator activities. 4,5 Monoterpene glycosides, such as albiflorin, oxypaeoniflorin, and paeoniflorin, have been isolated from P. lactiflora roots with galloyl and phenolic compounds, including benzoic acid, catechin, gallic acid, methyl gallate, paeonol, and 1,2,3,4,6-penta-O-galloyl-b-D-glucose (PGG).…”

Section: Introductionmentioning

confidence: 99%

Differences in the Chemical Profiles and Biological Activities of Paeonia lactiflora and Paeonia obovata

Bae

Kim²,

Kim³

et al. 2015

Journal of Medicinal Food

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Paeonia lactiflora and P. obovata are perennial herbs, each root of which has been consumed as a major oriental medicine, Paeoniae Radix and a famous folk medicine, Mountain Paeony Root, respectively. Although morphological studies have been performed comparing these two plants, there is insufficient scientific evidence that characterizes the differences in their chemical profiles and biological activities. Hence, the present study was undertaken to compare these two medicinal foods using a high-performance liquid chromatography-diode-array detector (HPLC-DAD) analysis and a gastric ulcer model in mice. HPLC analysis employed to assess the nine components revealed that P. lactiflora exhibited higher contents of phenolic compounds than P. obovata. Although a monoterpene glycoside, 60 -O-acetylpaeoniflorin was identified in P. obovata, it was not detected in P. lactiflora. Multivariate statistical analysis for HPLC data revealed that the orthogonal projections to latent structure-discriminant analysis is more appropriate than principal component analysis for differentiating the two groups. Moreover, the 50% methanol P. lactiflora extract (PL) was more effective against experimental gastric ulcer than P. obovata extract (PO) in the HCl/ethanol-induced ulcer model. In addition, PL displayed higher 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and lower nitric oxide production in a murine macrophage cell line, RAW 264.7, than PO. The DPPH radical scavenging activity of PL was as high as that of the positive control, butylated hydroxytoluene, at a concentration of 25 lg/mL.

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Section: Introductionmentioning

confidence: 99%

Differences in the Chemical Profiles and Biological Activities of Paeonia lactiflora and Paeonia obovata

Bae

Kim²,

Kim³

et al. 2015

Journal of Medicinal Food

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“…Paeoniflorin, a monoterpene glucoside, is the principal bioactive constituent of peony root (40). Paeoniflorin has reportedly exhibited anti-inflammation, immunoregulation, antiarthritis, antihepatitis, pain-relieving, neuromuscular blocking, and antihyperglycemia effects (15,32,40,41). Previous studies have shown that paeoniflorin suppresses TNF-␣ induced chemokine production in human dermal microvascular endothelial cells by blocking the NF-B and ERK pathway (2).…”

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confidence: 99%

Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway

Zhang

Dou

Zhang

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

110

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Paeonia lactiflora Pall is one of the most well-known herbs in China, Korea, and Japan for more than 1,200 years. Paeoniflorin, the major bioactive component of peony root, has recently been reported to have anticolitic activity. However, the underlying molecular mechanism is unclear. The present study was to explore the possible mechanism of paeoniflorin in attenuating dextran sulfate sodium (DSS)-induced colitis. Pre- and coadministration of paeoniflorin significantly reduced the severity of colitis and resulted in downregulation of several inflammatory parameters in the colon, including the activity of myeloperoxidase (MPO), the levels of TNF-α and IL-6, and the mRNA expression of proinflammatory mediators (MCP-1, Cox2, IFN-γ, TNF-α, IL-6, and IL-17). The decline in the activation of NF-κB p65, ERK, JNK, and p38 MAPK correlated with a decrease in mucosal Toll-like receptor 4 (TLR4) but not TLR2 or TLR5 expression. In accordance with the in vivo results, paeoniflorin downregulated TLR4 expression, blocked nuclear translocation of NF-κB p65, and reduced the production of IL-6 in LPS-stimulated mouse macrophage RAW264.7 cells. Transient transfection assay performed in LPS-stimulated human colon cancer HT-29 cells indicated that paeoniflorin inhibits NF-κB transcriptional activity in a dose-dependent manner. TLR4 knockdown and overexpression experiments demonstrated a requirement for TLR4 in paeoniflorin-mediated downregulation of inflammatory cytokines. Thus, for the first time, the present study indicates that paeoniflorin abrogates DSS-induced colitis via decreasing the expression of TLR4 and suppressing the activation of NF-κB and MAPK pathways.

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“…Total Glucosides Peony (TGP) is the major active component extracted from Radix Paeoniae, and it is the most common extractive of CHM without evident side-effect for rheumatic disorders (Zhang et al, 2012;Chen et al, 2013). Some pharmacological studies have shown that TGP play an important role in anti-inflammatory, analgesic and immune-modulatory (Zhang et al, 2012). Both in vitro and in vivo studies support that TGP significantly inhibits productions of pro-inflammatory cytokines or inflammatory cell infiltration.…”

Section: Paeonia Lactifloramentioning

confidence: 99%

“…It is used either alone or combined with other herbs to treat patients with pSS (Zheng et al, 2011; Chang et al, 2015). Total Glucosides Peony (TGP) is the major active component extracted from Radix Paeoniae, and it is the most common extractive of CHM without evident side-effect for rheumatic disorders (Zhang et al, 2012;Chen et al, 2013). Some pharmacological studies have shown that TGP play an important role in anti-inflammatory, analgesic and immune-modulatory (Zhang et al, 2012).…”

mentioning

confidence: 99%

Fatigue in patients with Sjögren’s syndrome and intervention of traditional herbal medicine

Li¹,

Zhang²

2016

Afr. J. Trad. Compl. Alt. Med.

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Background: Fatigue is the main complaint exiting in patients with primary Sjögren's Syndrome (pSS) but rarely addressed.Patients described it as an uncontrollable symptom of lack of energy, which has negative impacts on health related quality of life. To date, many studies have demonstrated that cytokines, depression, sleep and endocrine disturbance interrelated with pSS-related fatigue. However, the pathogenesis remains unclear. With a long history, Traditional Chinese Medicine (TCM) as alternative therapy has become increasingly popular among patients with various kinds of disease, especially in pSS. Based on the unique principle of therapy, practitioners have achieved a satisfactory effect on relieving disease-related symptoms with Chinese Herbal Medicine (CHM). Materials and Methods:In this article, we succinctly reviewed the highly correlated factors to pSS-related fatigue from the standpoint of western medicine. Then, from TCM perspective, we illustrated that theoretic mechanisms lead to fatigue in patients with pSS.Results: According to the theory of TCM, we concluded that CHM as complementary and alternative medicines are attractive options to alleviate pSS-related fatigue. Conclusion:In clinic, physicians should remember to inquire whether their patients are worn out easily. Combination of Yin-tonifying and Qi-tonifying CHM may be the optimal options to pSS-related fatigue. Key words：Sjögren's IntroductionFatigue is one of common symptoms in series of diseases, such as the various cancers (Stone et al., 2008), rheumatic diseases (Overman et al., 2015) and neurological diseases (Brola et al., 2007). Among patients with rheumatic diseases, including Rheumatoid Arthritis (RA), scleroderma, fibromyalgia, and Sjögren's Syndrome etc., prevalence of fatigue has been reported about 65% (Overman et al., 2015), compared with about 20% to 30% of general population (Loge et al., 1998;van't et al., 2010].Approximately, it ranges from 60% to 70% of patients with pSS suffering from fatigue (Segal et al., 2008; Haldorsen et al., 2011 The basis of pathologies is attributed to lymphocytic infiltration leading to exocrine glands dysfunction, especially lachrymal and salivary glands, and severe systemic symptoms involvement.The main symptoms were showed persistent dryness of mouth and eyes, and extra-glandular symptoms such as arthritis, vasculitis, and pain etc. Previous studies indicated that fatigue was more common and serious in patients with pSS than healthy controls (Barendregt et al.1998;van Leeuwen et al., 2015; Godaert et al., 2002), but as a clinical outcome of pSS, it is often ignored (Chaudhuri et al., 2004;Dupond, 2011).Some investigators suggest fatigue in pSS is not same as normal notion of tiredness, it is accurately described as fluctuant and ever-present lack of vitality, beyond individual's own control (Mengshoel et al., 2014), reducing health-related quality of life and work ability (Segal et al., 2009;Westhoff et al., 2011). Some patients with pSS usually complained that "little interest or ...

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Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis

Cited by 128 publications

References 28 publications

Differences in the Chemical Profiles and Biological Activities of Paeonia lactiflora and Paeonia obovata

Differences in the Chemical Profiles and Biological Activities of Paeonia lactiflora and Paeonia obovata

Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway

Fatigue in patients with Sjögren’s syndrome and intervention of traditional herbal medicine

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