Mechanisms Involved in the Improvement of Lipotoxicity and Impaired Lipid Metabolism by Dietary α-Linolenic Acid Rich Salvia hispanica L (Salba) Seed in the Heart of Dyslipemic Insulin-Resistant Rats

Creus, Agustina; Ferreira, María del Rosario; Oliva, María Eugenia; Lombardo, Yolanda B.

doi:10.3390/jcm5020018

Cited by 48 publications

(63 citation statements)

References 42 publications

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“…The compromised inflammatory state is usually attributed to higher levels of proinflammatory signaling from adipocytes. Dietary intervention studies have indicated that n-3 PUFA rich diet alleviates the metabolic syndromes through attenuating the inflammatory status of the system [23,24]. Hence, it was interesting to study the anti-inflammatory properties of Indian chia seeds in an in vitro setup.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Anticancer and Anti-Lipoxygenase Activities of Chia Seed Oil and Its Blends With Selected Vegetable Oils

Gazem

Puneeth

Madhu

et al. 2017

Asian J Pharm Clin Res

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Objective: To investigate the anticancer and anti-inflammatory potential of chia seed oil (CSO) and its blends in vitro. Methods:The in vitro cancer cytotoxic properties ability of CSO and its blends was evaluated by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) and trypan blue assays using major cell lines including chronic myelogenous leukemia, HeLa and MCF-7 cells. The anti-inflammatory effect of the CSO and its blends was studied by assessing the anti-lipoxygenase (LOX) activity in vitro.Results: Incubation with CSO alone significantly inhibited the LOX activity. In the combination groups, CSO slightly increased the inhibition among blends of soybean and palmolein oils. In addition, CSO alone and in blends demonstrated potent and differential anticancer activity in MTT and trypan blue assays. Conclusion:Our results pave the way for the conclusion that CSO alone or in combination with the vegetable oils proves to be a healthy synergistic supplement or an adjuvant for the current diet. The supplementation with CSO is suggested for the modern lifestyle to delay or prevent the incidence of degenerative disorders.

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Section: Resultsmentioning

confidence: 99%

In Vitro Anticancer and Anti-Lipoxygenase Activities of Chia Seed Oil and Its Blends With Selected Vegetable Oils

Gazem

Puneeth

Madhu

et al. 2017

Asian J Pharm Clin Res

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“…[13] Now with recent peer-reviewed evidence, chia seeds have been associated with possible effectiveness for allergies, angina, athletic performance enhancement, diabetes, cancer, coronary artery disease, myocardial infarctions, hormonal and endocrine disorders, hyperlipidemia, hypertension, stroke, vasodilatation, anticoagulant, and antiviral effects. [7,8,[13][14][15][16] Up until now, there have been no studies or analyses documenting adverse harms from chia seeds, specifically with obstruction as described above. [17][18][19] When added to liquid at room temperature (see Figure 3), dry chia seeds immediately begin to form a hydrogel gum capsule absorbing up to 27 times their weight in water, [6] which exhibits a non-Newtonian fluid behavior.…”

Section: Discussionmentioning

confidence: 99%

Watch it grow: Esophageal impaction with chia seeds

Simmelink

Rawl

Browne

et al. 2017

CRIM

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Esophageal obstructions are a medical emergency, due to inability to control secretions and risk of perforation. Epidemiology of esophageal foreign-body impaction has evolved to include increasing incidence of non-meat food causes as well as increasing underlying prevalence of pathologies including eosinophilic esophagitis. Chia seeds, a staple known for health benefits, have an uncanny ability to absorb large quantities of water leading to a hydrated gel-like substance which can cause an obstruction. We report the first case of chia seed impaction in a patient with likely eosinophilic esophagitis.

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“…El contenido de glucose-6-fosfato, glucó-geno y la actividad de la enzima hexoquinasa se determinaron en homogeneizado de músculo cardíaco, como se describió previamente (11,12). Los niveles de glucosa-6-fosfato y glucógeno se expresan como µmol/gr de tejido húmedo.…”

Section: Determinación De La Presión Sanguíneaunclassified

“…Estudios previos de nuestro grupo y otros investigadores (12,24) constataron que la administración de una DRS induce un incremento de la presión arterial. Los resultados del presente trabajo señalan que un cambio en la fuente proteica (caseína por proteína de soja) fue capaz de normalizar la hipertensión.…”

Section: Actividad De La Enzima Hexoquinasa Contenido De Glucosa-6-funclassified

“…Estudios previos de nuestro grupo han demostrado que ratas normales alimentadas crónicamente con dietas ricas en sacarosa (DRS) desarrollan dislipemia, alterada homeostasis de la glucosa, resistencia insulínica, lipotoxicidad e hipertensión. En el músculo cardíaco de estos animales se observó una alteración de las vías no oxidativas y oxidativas de la glucosa (9)(10)(11)(12).…”

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Efectos de la proteína de soja aislada sobre la hipertensión y el alterado metabolismo de la glucosa en musculo cardíaco de ratas dislipemicas insulino resistentes.

Oliva¹,

Chicco²,

Lombardo³

2017

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Efectos de la proteína de soja aislada sobre la hipertensión y el alterado metabolismo de la glucosa en músculo cardíaco de ratas dislipémicas insulino resistentes Oliva, M.E. • Chicco, A.G.• Lombardo, Y.B.Departamento de Ciencias Biológicas. Cátedra de Química Biológica. Laboratório de Estudio de Enfermedades Metabólicas relacionadas con la nutrición. Facultad de Bioquímica y Ciencias Biológicas. Universidad Nacional del Litoral. Ciudad Universitaria. Paraje El Pozo S/N. S3000ZAA, CC 242, Santa Fe, Argentina. Teléfono: 54-342-4575211 e-mail: meoliva@fbcb.unl.edu.ar RESUMEN: El objetivo del trabajo fue analizar los efectos de la administración de proteína de soja aislada, sobre la hipertensión y alteraciones del metabolismo de la glucosa presentes en el músculo cardíaco de ratas dislipémicas insulino resistentes, inducidas por una ingesta crónica de una dieta rica en sacarosa (DRS). Ratas machos Wistar recibieron durante 4 meses DRS. Finalizado este período, la mitad de los animales continuó con la DRS y en la otra mitad la proteína de soja aislada sustituyó a la caseína como fuente proteica (DRS+PS) durante 4 meses adicionales. El grupo control (DC) consumió dieta control durante toda la experiencia. Los resultados alcanzados demuestran que ésta manipulación dietaria fue capaz de revertir la hipertensión arterial normalizando la alterada fosforilación de la glucosa -estimada por la actividad hexoquinasa-y el contenido de glucosa-6-fosfato y glucógeno en el músculo cardíaco. La sustitución de caseína por proteína de soja como fuente proteica normalizó los niveles plasmáticos de triglicéridos, ácidos grasos no esterificados y la moderada hiperglucemia sin cambios en la insulinemia. La sensibilidad insulínica periférica global mejoró notablemente aunque sin alcanzar valores del grupo DC. Los resultados obtenidos muestran a la proteína de soja dietaria como una herramienta nutricional capaz de normalizar la presión arterial, la fosforilación y la vía no oxidativa de la glucosa en el músculo cardíaco en este modelo experimental.PALABrAs CLAvEs: proteína de soja, dislipidemia, hipertensión, músculo cardíaco. sUMMArY: Effects of isolated soy protein on blood pressure and altered glucose metabolism in the heart muscle of dyslipemic insulin-resistant rats. The present study analyzes the effect of dietary isolated soy protein on hypertension and impaired glucose metabolism present in the heart muscle of dyslipemic insulinresistant rats fed a sucrose-rich diet (SRD). Male Wistar rats received a SRD for 4 months. At this time half of the animals continue with the same diet for up to 8 months, the other half was fed an SRD in which isolated soy protein replaced casein as protein source (DRS+PS) for 4 additional months. The control group (CD) consumed control diet throughout the experimental diet. The results obtained show that this dietary manipulation was able to reverse the hypertension normalizing Introducción El síndrome metabólico (SM) comprende un conjunto interrelacionado de desórde-nes metabólicos que incluyen entre...

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Mechanisms Involved in the Improvement of Lipotoxicity and Impaired Lipid Metabolism by Dietary α-Linolenic Acid Rich Salvia hispanica L (Salba) Seed in the Heart of Dyslipemic Insulin-Resistant Rats

Cited by 48 publications

References 42 publications

In Vitro Anticancer and Anti-Lipoxygenase Activities of Chia Seed Oil and Its Blends With Selected Vegetable Oils

In Vitro Anticancer and Anti-Lipoxygenase Activities of Chia Seed Oil and Its Blends With Selected Vegetable Oils

Watch it grow: Esophageal impaction with chia seeds

Efectos de la proteína de soja aislada sobre la hipertensión y el alterado metabolismo de la glucosa en musculo cardíaco de ratas dislipemicas insulino resistentes.

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