Mechanisms involved in the gastroprotective activity of Celtis iguanaea (Jacq.) Sargent on gastric lesions in mice

Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms

“…The ulcerogenic agent exerts direct toxic effect on epithelium and solubilises the gastric mucus (Martins et al, 2014) and is characterized by multiple hemorrhagic streaks along the glandular part of the stomach. This process of gastric ulceration can be blocked or successfully treated with potent gastroprotective agent, making the model a useful experimental tool to evaluate the capacity of a test agent in protecting the gastric mucosa (Júnior et al, 2014).…”

“…The potential effect of SIECm on ulcer healing was tested using the acetic acidinduced method (Takagi et al, 1969;Martins et al, 2014). The mice were first acclimatized in the laboratory by undergoing a period of adaptation against stress involved in the study as follows: the animals received distilled water (10 mL/kg) given orally; followed by food for 2 h per day for three days, were then fasted for 12 h prior to the commencement of the experiment.…”

Effects of Hydroalcoholic Extract of <em>Celtis iguanaea </em>on Markers of Cardiovascular Diseases and Glucose Metabolism in Cholesterol-Fed Rats

“…3 of 24 Recently, a gastro-protective effect of the hexane fraction of the ethanolic extract was observed using different models of gastric ulcers [19,20,21]. The aqueous extract administered to mice demonstrated no cytotoxic or genotoxic effects [22], and in a toxicity test in Artemia salina, the ethanolic extract of C. iguanaea bark and its fractions showed an LC50 higher than 1000 μg/mL, indicating the absence of a toxic effect [23].…”

Safety Assessment of Esporão de Galo (Celtis iguanaea (Jacq.) Sargent) Crude Extract from Leaves: Acute and Subacute Toxicity Studies in Male Rats

“…This species is an angiosperm and dicotyledonous characterized as a shrub or small tree with a thorny plant, 6 m to 9 m high, with rounded crown and branches, having canopy in pyramidal shape and an upright cylindrical trunk of 15 cm to 30 cm in diameter. It blooms from August to October, and its fruits ripen from February to March [4][5][6]. The infusion of its leaves is popularly used in the treatment of joint pain, asthma, cramps and poor digestion, as a diuretic, and in the treatment of gastric ulcers [4][5][6][7].…”

“…Preliminary data from Martins et al [5] showed antiulcerogenic and secretory efficacy of hexane extract of leaf the plant suggesting anticholinergic and antihistaminergic mechanism. Hereafter, Martins et al [6] demonstrated that the hexane extract of C. iguanaea leaves exhibits gastro protective activity in different gastric ulcer models.…”