Mechanisms in fluid retention – towards a mutual concept

Mottelson, Mathis N.; Lundsgaard, Christen; Möller, Sören

doi:10.1111/cpf.12615

Cited by 5 publications

(4 citation statements)

References 83 publications

(192 reference statements)

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“…As normal pregnancy is associated with fluid and sodium retention [ 51 ], the attention around the possible role of EDLF in pregnancy arose after their discovery [ 52 ]. In 1984, two research teams found an endogenous factor that cross-reacted with digoxin antibodies in the serum of pregnant women, and increased levels of this factor were associated with hypertensive disorders of pregnancy [ 53 , 54 ].…”

Section: Endogenous Digitalis-like Factors (Edlf)mentioning

confidence: 99%

Endogenous Digitalis-like Factors as a Key Molecule in the Pathophysiology of Pregnancy-Induced Hypertension and a Potential Therapeutic Target in Preeclampsia

Socha,

Chmielewski,

Pietrus

et al. 2023

IJMS

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Preeclampsia (PE), the most severe presentation of hypertensive disorders of pregnancy, is the major cause of morbidity and mortality linked to pregnancy, affecting both mother and fetus. Despite advances in prophylaxis and managing PE, delivery of the fetus remains the only causative treatment available. Focus on complex pathophysiology brought the potential for new treatment options, and more conservative options allowing reduction of feto-maternal complications and sequelae are being investigated. Endogenous digitalis-like factors, which have been linked to the pathogenesis of preeclampsia since the mid-1980s, have been shown to play a role in the pathogenesis of various cardiovascular diseases, including congestive heart failure and chronic renal disease. Elevated levels of EDLF have been described in pregnancy complicated by hypertensive disorders and are currently being investigated as a therapeutic target in the context of a possible breakthrough in managing preeclampsia. This review summarizes mechanisms implicating EDLFs in the pathogenesis of preeclampsia and evidence for their potential role in treating this doubly life-threatening disease.

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Section: Endogenous Digitalis-like Factors (Edlf)mentioning

confidence: 99%

Endogenous Digitalis-like Factors as a Key Molecule in the Pathophysiology of Pregnancy-Induced Hypertension and a Potential Therapeutic Target in Preeclampsia

Socha,

Chmielewski,

Pietrus

et al. 2023

IJMS

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“…Penurunan laju filtrasi glomerulus (GFR) menyebabkan retensi Na dan H2O dalam tubuh sehingga menyebabkan penumpukan cairan. (Mottelson et al, 2020) Fungsi utama ginjal untuk mempertahankan homeostatik yaitu mengatur volume cairan, asam basa, keseimbangan osmotik, eksresi sisa metabolism, sistem pengaturan hormonal serta metabolisme. Ketika terjadi kegagalan pada fungsi ginjal, tubuh tidak dapat mempertahankan metabolisme serta keseimbangan cairan & elektrolit, maka terjadi penumpukan sisa-sisa metabolik (toksik uremik) dalam darah serta penumpukan cairan (Galuh et al, 2020).…”

Section: Pendahuluanunclassified

Analisis Asuhan Keperawatan Pada Pasien Chronic Kidney Disease Dengan Cardiorenal Syndrome di Ruang Intensif Care Unit

Sholekah,

Baidhowy

2023

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Penyakit ginjal dan jantung merupakan penyakit yang memiliki tingkat morbiditas dan mortalitas yang tinggi. Organ ginjal dan jantung memiliki faktor risiko vaskular yang sama dan saling terkait. Disfungsi pada satu organ tersebut akan mempengaruhi satu organ lainnya. Hubungan permasalahan dua organ disebut dengan Cardiorenal Syndrome (CRS). Penanganan intervensi kombinasi ginjal dan jantung membutuhkan analisis yang dalam. Studi kasus ini bertujuan untuk menganalisis kasus Chronic Kidney Disease (CKD) pada pasien dengan Cardiorenal Syndrome (CRS) di ruang Intensif Care Unit (ICU). Studi kasus ini menggunakan metode case report dengan single case yang dilakukan melalui rangkaian proses asuhan keperawatan berupa pengkajian, perumusan masalah keperawatan, intervensi, implementasi, dan evaluasi keperawatan. Studi kasus ini dilakukan dengan cara memberikan asuhan keperawatan pada pasien CKD di ruang ICU selama 5 hari. Masalah keperawatan utama pada pasien Cardiorenal Syndrome yaitu penurunan curah jantung berhubungan dengan preload dan kontraktilitas. Hasil evaluasi asuhan keperawatan selama 5 hari menunjukkan hemodinamika membaik, nadi perifer teraba agak kuat, takikardia menurun, edema menurun dari derajat 2 menjadi derajat 1, hemoglobin membaik, belum ada hasil pemeriksaan TTE (Transthoracic echocardiography) ulang, dan kesadaran pasien masih soporcoma E2M2Vett. Proses keperawatan yang tepat dapat berkontribusi terhadap perbaikan hemodinamika, penurunan derajat edema, serta perbaikan hemoglobin pasien Chronic Kidney Disease (CKD) dengan Cardiorenal Syndrome (CRS).

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“…As a normal pregnancy is accompanied by fluid retention and a positive sodium balance in the body [15], interest in the possible role of CS in pregnancy arose shortly after their discovery. Graves et al showed that the level of digoxin-like immunoreactivity increases moderately in a healthy pregnancy and rises significantly with gestational hypertension [16].…”

Section: Cardiotonic Steroids Pregnancy and Preeclampsiamentioning

confidence: 99%

Preeclampsia: Cardiotonic Steroids, Fibrosis, Fli1 and Hint to Carcinogenesis

Agalakova

Kolodkin

Adair

et al. 2021

IJMS

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Despite prophylaxis and attempts to select a therapy, the frequency of preeclampsia does not decrease and it still takes the leading position in the structure of maternal mortality and morbidity worldwide. In this review, we present a new theory of the etiology and pathogenesis of preeclampsia that is based on the interaction of Na/K-ATPase and its endogenous ligands including marinobufagenin. The signaling pathway of marinobufagenin involves an inhibition of transcriptional factor Fli1, a negative regulator of collagen synthesis, followed by the deposition of collagen in the vascular tissues and altered vascular functions. Moreover, in vitro and in vivo neutralization of marinobufagenin is associated with the restoration of Fli1. The inverse relationship between marinobufagenin and Fli1 opens new possibilities in the treatment of cancer; as Fli1 is a proto-oncogene, a hypothesis on the suppression of Fli1 by cardiotonic steroids as a potential anti-tumor therapeutic strategy is discussed as well. We propose a novel therapy of preeclampsia that is based on immunoneutralization of the marinobufagenin by monoclonal antibodies, which is capable of impairing marinobufagenin-Na/K-ATPase interactions.

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Mechanisms in fluid retention – towards a mutual concept

Cited by 5 publications

References 83 publications

Endogenous Digitalis-like Factors as a Key Molecule in the Pathophysiology of Pregnancy-Induced Hypertension and a Potential Therapeutic Target in Preeclampsia

Endogenous Digitalis-like Factors as a Key Molecule in the Pathophysiology of Pregnancy-Induced Hypertension and a Potential Therapeutic Target in Preeclampsia

Analisis Asuhan Keperawatan Pada Pasien Chronic Kidney Disease Dengan Cardiorenal Syndrome di Ruang Intensif Care Unit

Preeclampsia: Cardiotonic Steroids, Fibrosis, Fli1 and Hint to Carcinogenesis

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