Mechanisms impairing blood pressure responses to nitrite and nitrate

Oliveira-Paula, Gustavo H.; Pinheiro, Lucas C.; Tanus‐Santos, José Eduardo

doi:10.1016/j.niox.2019.01.015

Cited by 34 publications

(29 citation statements)

References 163 publications

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“…The sustained presence of angiotensin II type 1 receptor antagonists prevents and attenuates the development of hypertension, cardiac hypertrophy, oxidative stress, and renal injury in SHR [21]. In addition, hypertension is associated with impaired NO production and bioavailability [22]. Our results show that VOO, independently of the polyphenol content, produced a decrease in plasma angiotensin II and urinary endothelin-1 concentrations, and, in parallel, an increase of NO.…”

Section: Discussionmentioning

confidence: 69%

Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

et al. 2019

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Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. We studied the effects of chronic consumption of extra virgin olive oil (EVOO), enriched in bioactive compounds from olive fruit and leaves, on blood pressure, endothelial function, oxidative and inflammatory status, and circulating cholesterol levels, in spontaneously hypertensive rats (SHR). Thirty SHR were randomly assigned to three groups: a control untreated SHR group, an SHR group (1 mL/rat/day) of a control olive oil (17.6 mg/kg of phenolic compounds), and an SHR group (1 mL/rat/day) of the enriched EVOO (750 mg/kg of phenolic compounds) for eight weeks. Ten Wistar Kyoto rats (WKY) were included as healthy controls. Long-term administration of the enriched EVOO decreased systolic blood pressure and cardiac hypertrophy, and improved the ex vivo aortic endothelial dysfunction measured in SHR. Moreover, enriched oil supplementation reduced the plasma levels of Angiotensin II and total cholesterol, and the urinary levels of endothelin-1 and oxidative stress biomarkers, while pro-inflammatory cytokines were unaffected. In conclusion, sustained treatment with EVOO, enriched in bioactive compounds from the olive fruit and leaves, may be an effective tool for reducing blood pressure and cholesterol levels alone or in combination with pharmacological anti-hypertensive treatment.

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Section: Discussionmentioning

confidence: 69%

Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

et al. 2019

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“…However, as we observed in this study, the increase in the expression of the iNOS isoform occurs only after 15 days; it is possible that this modulation occurs at different times of reperfusion, with an increase hours after ischemia in response to the injury as observed in these studies and another increase after few weeks in response to the increase in inflammatory cytokines at 8 d and organ atrophy as already observed by our group [ 5 ]. Once produced, NO can be rapidly converted mostly into NO 2 − , nitrate (NO 3 − ), and RSNO working both as oxidant and antioxidant agents [ 29 , 30 ]. Several studies have already demonstrated in I/R models the role of NO 2 − as a potent mediator of cytoprotection by inhibiting mitochondrial complex I activity after ischemia, attenuating the generation of mitochondrial ROS.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Oxidative Stress in Renal Ischemia/Reperfusion-Induced Cardiorenal Syndrome Type 3

Caio‐Silva

Dias

Junho

et al. 2020

BioMed Research International

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In kidney disease (KD), several factors released into the bloodstream can induce a series of changes in the heart, leading to a wide variety of clinical situations called cardiorenal syndrome (CRS). Reactive oxygen species (ROS) play an important role in the signaling and progression of systemic inflammatory conditions, as observed in KD. The aim of the present study was to characterize the redox balance in renal ischemia/reperfusion-induced cardiac remodeling. C57BL/6 male mice were subjected to occlusion of the left renal pedicle, unilateral, for 60 min, followed by reperfusion for 8 and 15 days, respectively. The following redox balance components were evaluated: catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (FRAP), NADPH oxidase (NOX), nitric oxide synthase (NOS), hydrogen peroxide (H2O2), and the tissue bioavailability of nitric oxide (NO) such as S-nitrosothiol (RSNO) and nitrite (NO2−). The results indicated a process of renoprotection in both kidneys, indicated by the reduction of cellular damage and some oxidant agents. We also observed an increase in the activity of antioxidant enzymes, such as SOD, and an increase in NO bioavailability. In the heart, we noticed an increase in the activity of NOX and NOS, together with increased cell damage on day 8, followed by a reduction in protein damage on day 15. The present study concludes that the kidneys and heart undergo distinct processes of damage and repair at the analyzed times, since the heart is a secondary target of ischemic kidney injury. These results are important for a better understanding of the cellular mechanisms involved in CRS.

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“…Third, in addition to mouthwashes, several other agents can disrupt the nitrate-nitrite-NO pathway, such as smoking, antibiotics, high concentrations of ascorbate, and proton-pump inhibitors [107]. Concerning the latter, Montenegro et al demonstrated in a randomized, double-blind, placebo-controlled, cross-over study in healthy subjects that the blood pressure lowering effect of oral nitrite ingestion remains absent when pretreated with esomeprazole [108].…”

Section: Discussionmentioning

confidence: 99%

Antiseptic mouthwash, the nitrate–nitrite–nitric oxide pathway, and hospital mortality: a hypothesis generating review

Blot

2020

Intensive Care Med

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Meta-analyses and several large cohort studies have demonstrated that antiseptic mouthwashes are associated with mortality in hospitalized patients. A clear pathogenic mechanism is lacking, leading to controversy and a reluctance to abandon or limit the use of antiseptic mouthwashes. Here, we generate the hypothesis that a disturbance in nitric oxide homeostasis by antiseptic mouthwashes may be responsible for the observed increase in mortality risk. Nitric oxide is essential in multiple physiological processes, and a reduction in nitric oxide bioavailability is associated with the occurrence or worsening of pathologies, such as atherosclerosis, diabetes, and sepsis. Oral facultative anaerobic bacteria are essential for the enterosalivary nitrate-nitrite-nitric oxide pathway due to their capacity to reduce nitrate to nitrite. Nitrate originates from dietary sources or from the active uptake by salivary glands of circulating nitrate, which is then excreted in the saliva. Because antiseptic mouthwashes eradicate the oral bacterial flora, this nitric oxide-generating pathway is abolished, which may result in nitric oxide-deficient conditions potentially leading to life-threatening complications such as ischaemic heart events or sepsis.

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Mechanisms impairing blood pressure responses to nitrite and nitrate

Cited by 34 publications

References 163 publications

Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

Characterization of the Oxidative Stress in Renal Ischemia/Reperfusion-Induced Cardiorenal Syndrome Type 3

Antiseptic mouthwash, the nitrate–nitrite–nitric oxide pathway, and hospital mortality: a hypothesis generating review

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