Mechanisms for tolerance to methamphetamine effects

Gygi, Melanie P.; Gygi, Stephen; Johnson, Michael D.; Wilkins, Diana G.; Gibb, James W.; Hanson, Glen R.

doi:10.1016/0028-3908(96)84647-8

Cited by 42 publications

(45 citation statements)

References 9 publications

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“…Controlled preclinical and clinical studies have previously demonstrated tolerance to these effects of methamphetamine (eg Segal et al, 2003;Comer et al, 2001). Further, there is also evidence that animals treated with gradually increasing doses of methamphetamine develop a partial tolerance to the neurotoxic effects of methamphetamine toward brain dopamine and serotonin neurons (Schmidt et al, 1985;Gygi et al, 1996;Segal et al, 2003). Similar studies are not available for MDMA, but the present data suggesting marked behavioral tolerance to the effects of MDMA indicate that such studies are in order.…”

Section: Discussionsupporting

confidence: 52%

Plasma Drug Concentrations and Physiological Measures in ‘Dance Party’ Participants

Irvine

Keane

Felgate

et al. 2005

Neuropsychopharmacol

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The increasing use of (7) 3,4-methylenedioxymethamphetamine (MDMA) in the setting of large dance parties ('raves') and clubs has been the source of some concern, because of potential acute adverse events, and because animal studies suggest that MDMA has the potential to damage brain serotonin (5-HT) neurons. However, it is not yet known whether MDMA, as used in the setting of dance parties, leads to plasma levels of MDMA that are associated with toxicity to 5-HT neurons in animals. The present study sought to address this question. Plasma MDMA concentrations, vital signs, and a variety of blood and urine measures were obtained prior to, and hours after, individuals attended a dance party. After the dance party, subjects were without clinical complaints, had measurable amounts of residual MDMA in plasma, and nearly half of the subjects also tested positive for methamphetamine, another amphetamine analog that has been shown to have 5-HT neurotoxic potential in animals. Plasma concentrations of MDMA did not correlate with self-reported use of 'ecstasy' and, in some subjects, overlapped with those that have been associated with 5-HT neurotoxicity in non-human primates. Additional subjects were likely to have had similar concentrations while at the dance party, when one considers the reported time of drug ingestion and the plasma half-life of MDMA in humans. Hematological and biochemical analyses were generally unremarkable. Moderate increases in blood pressure, heart rate and body temperature were observed in the subjects with the highest MDMA plasma concentrations. These findings are consistent with epidemiological findings that most people who use MDMA at dance parties do not develop serious clinical complications, and suggest that some of these individuals may be at risk for developing MDMA-induced toxicity to brain serotonin neurons.

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Section: Discussionsupporting

confidence: 52%

Plasma Drug Concentrations and Physiological Measures in ‘Dance Party’ Participants

Irvine

Keane

Felgate

et al. 2005

Neuropsychopharmacol

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“…31 Several energy differences and relaxations were checked with the Qbox, 30 FPLO, 28 and WIEN2K 29 codes. In the 40-70 GPa range, all five of the structures we have studied have enthalpies that differ by less than 20 meV/Ca (230 K/Ca), as shown in Fig.…”

Section: The Enthalpiesmentioning

confidence: 99%

Competing phases, strong electron-phonon interaction, and superconductivity in elemental calcium under high pressure

Gygi

Pickett

2009

Phys. Rev. B

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The observed "simple cubic" (sc) phase of elemental Ca at room temperature in the 32-109 GPa range is, from linear response calculations, dynamically unstable. By comparing first principle calculations of the enthalpy for five sc-related (non-close-packed) structures, we find that all five structures compete energetically at room temperature in the 40-90 GPa range, and three do so in the 100-130 GPa range. Some competing structures below 90 GPa are dynamically stable, i.e., no imaginary frequency, suggesting that these sc-derived short-range-order local structures exist locally and can account for the observed (average) "sc" diffraction pattern. In the dynamically stable phases below 90 GPa, some low frequency phonon modes are present, contributing to strong electron-phonon (EP) coupling as well as arising from the strong coupling. Linear response calculations for two of the structures over 120 GPa lead to critical temperatures in the 20-25 K range as is observed, and do so without unusually soft modes.

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“…It has been shown that chronic MA exposure in escalating doses leads to behavioral and neurochemical sensitization (Gygi et al, 1996;Itzhak and Ali, 2002;Segal et al, 2003). Thomas and Kuhn (2005) observed that intermittent exposure to low doses of MA attenuated the microglial response and led to the development of tolerance to MA toxicity in mice.…”

Section: Do Preclinical Studies Of Ma-induced Motor Abnormalities Tramentioning

confidence: 99%

Do Preclinical Findings of Methamphetamine-Induced Motor Abnormalities Translate to an Observable Clinical Phenotype?

Caligiuri

Buitenhuys

2005

Neuropsychopharmacol

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This review summarizes the preclinical literature of the effects of methamphetamine (MA) on subcortical dopaminergic and GABAergic mechanisms underlying motor behavior with the goal of elucidating the clinical presentation of human MA-induced movement disorders. Acute and chronic MA exposure in laboratory animal can lead to a variety of motor dysfunctions including increased locomotor activity, stereotypies, diminished or enhanced response times, and parkinsonian-like features. With the exception of psychomotor impairment and hyperkinesia, MA-induced movement disorders are not well documented in humans. This review attempts to draw parallels between the animal and human changes in basal ganglia neurochemistry associated with MA exposure and offers explanations for why a parkinsonian phenotype is not apparent among individuals who use and abuse MA. Significant differences in the expression of neurotoxicity and presence of multiple environmental and pharmacologic confounds may account for the lack of a parkinsonian phenotype in humans despite evidence of altered dopamine function.

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Mechanisms for tolerance to methamphetamine effects

Cited by 42 publications

References 9 publications

Plasma Drug Concentrations and Physiological Measures in ‘Dance Party’ Participants

Plasma Drug Concentrations and Physiological Measures in ‘Dance Party’ Participants

Competing phases, strong electron-phonon interaction, and superconductivity in elemental calcium under high pressure

Do Preclinical Findings of Methamphetamine-Induced Motor Abnormalities Translate to an Observable Clinical Phenotype?

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