Mechanisms for the formation of membranous nanostructures in cell-to-cell communication

Schara, Karin; Janša, Vid; Šuštar, Vid; Dolinar, Drago; Pavlič, Janez; Lokar, Maruša; Kralj‐Iglič, Veronika; Veranič, Peter; Iglič, Aleš

doi:10.2478/s11658-009-0018-0

Cited by 51 publications

(40 citation statements)

References 80 publications

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“…The fact that there is an exchange of molecules between D. vulgaris and E. coli, but not between C. acetobutylicum and E. coli, is compatible with this hypothesis, because E. coli, like C. acetobutylicum, is able to ferment glucose, and is not suffering a nutrient stress condition in the GY medium. The communication between bacteria, which can take several forms [33][34][35][36][37][38] , is essential for coordinating the behaviour of the whole community. Thus, communication between cells in pure culture regulates the population density by emitting, receiving and responding to a chemical signal, that is, quorum sensing 39,40 .…”

Section: Discussionmentioning

confidence: 99%

Nutritional stress induces exchange of cell material and energetic coupling between bacterial species

et al. 2015

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Knowledge of the behaviour of bacterial communities is crucial for understanding biogeochemical cycles and developing environmental biotechnology. Here we demonstrate the formation of an artificial consortium between two anaerobic bacteria, Clostridium acetobutylicum (Gram-positive) and Desulfovibrio vulgaris Hildenborough (Gram-negative, sulfate-reducing) in which physical interactions between the two partners induce emergent properties. Molecular and cellular approaches show that tight cell-cell interactions are associated with an exchange of molecules, including proteins, which allows the growth of one partner (D. vulgaris) in spite of the shortage of nutrients. This physical interaction induces changes in expression of two genes encoding enzymes at the pyruvate crossroads, with concomitant changes in the distribution of metabolic fluxes, and allows a substantial increase in hydrogen production without requiring genetic engineering. The stress induced by the shortage of nutrients of D. vulgaris appears to trigger the interaction.

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Section: Discussionmentioning

confidence: 99%

Nutritional stress induces exchange of cell material and energetic coupling between bacterial species

et al. 2015

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“…Accordingly, it has been shown recently that the topography of a nanostructured implant surface is a decisive factor for surface cell adhesion and growth [33][34][35]. The models of the electric double layer presented may thus serve as a practical tool to find the nanostructured surface topography of implants with optimal electric field strength and electric potential distribution that would promote the protein and cation mediated adhesion of osteoblasts to the negatively charged implant surface [35] and also communication between cells [36].…”

Section: Langevin-bikerman Stern (Lbs) Model For Finite-sized Ionsmentioning

confidence: 99%

Generalized stern models of the electric double layer considering the spatial variation of permittvity and finite size of ions in saturation regime

Gongadze

Rienen

Iglič

2011

Cellular and Molecular Biology Letters

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Abstract:The interaction between a charged metal implant surface and a surrounding body fluid (electrolyte solution) leads to ion redistribution and thus to formation of an electrical double layer (EDL). The physical properties of the EDL contribute essentially to the formation of the complex implantbiosystem interface. Study of the EDL began in 1879 by Hermann von Helmholtz and still today remains a scientific challenge. The present mini review is focused on introducing the generalized Stern theory of an EDL, which takes into account the orientational ordering of water molecules. To ascertain the plausibility of the generalized Stern models described, we follow the classical model of Stern and introduce two Langevin models for spatial variation of the relative permittivity for point-like and finite sized ions. We attempt to uncover the subtle interplay between water ordering and finite sized ions and their impact on the electric potential near the charged implant surface. Two complementary effects appear to account for the spatial dependency of the relative permittivity near the charged implant surface -the dipole moment vectors of water molecules are predominantly oriented towards the surface and water molecules are depleted due to the accumulation of counterions. At the end the expressions for relative permittivity in both Langevin models were generalized by also taking into account the cavity and reaction field.

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“…Expression (62) obtained by statistical mechanics recovers the Helfrich isotropic bending energy (63) if…”

Section: F M H Da M C C a Ktm D D Ktmentioning

confidence: 99%

Stability of membranous nanostructures: a possible key mechanism in cancer progression

Kralj‐Iglič¹

2012

IJN

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Abstract:Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes. Recent results indicate that they constitute cell-cell communication systems and that cancer development is influenced by these systems. Nanovesicles that are pinched off from cancer cells can move within the circulation and interact with distant cells. It has been suggested and indicated by experimental evidence that nanovesicles can induce metastases from the primary tumor in this way. Therefore, it is of importance to understand better the mechanisms of membrane budding and vesiculation. Here, a theoretical description is presented concerning consistently related lateral membrane composition, orientational ordering of membrane constituents, and a stable shape of nanovesicles and nanotubules. It is shown that the character of stable nanostructures reflects the composition of the membrane and the intrinsic shape of its constituents. An extension of the fluid mosaic model of biological membranes is suggested by taking into account curvature-mediated orientational ordering of the membrane constituents on strongly anisotropically curved regions. Based on experimental data for artificial membranes, a possible antimetastatic effect of plasma constituents via mediation of attractive interaction between membranous structures is suggested. This mediated attractive interaction hypothetically suppresses nanovesiculation by causing adhesion of buds to the mother membrane and preventing them from being pinched off from the membrane.

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Mechanisms for the formation of membranous nanostructures in cell-to-cell communication

Cited by 51 publications

References 80 publications

Nutritional stress induces exchange of cell material and energetic coupling between bacterial species

Nutritional stress induces exchange of cell material and energetic coupling between bacterial species

Generalized stern models of the electric double layer considering the spatial variation of permittvity and finite size of ions in saturation regime

Stability of membranous nanostructures: a possible key mechanism in cancer progression

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