Mechanisms for surface energy changes observed in plasma immersion ion implanted polyethylene: The roles of free radicals and oxygen-containing groups

Kondyurin, Alexey; Naseri, Pourandokht; Fisher, Karen R.; McKenzie, David R.; Bilek, Marcela M.M.

doi:10.1016/j.polymdegradstab.2009.01.004

Cited by 64 publications

(59 citation statements)

References 27 publications

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“…The plasma polymers and plasma-modified surfaces created using energetic ion bombardment reported more recently are even more hydrophilic (Yin et al 2009e;Kondyurin et al 2009b) than the most hydrophilic surface studied in the earlier works, but nevertheless show much higher levels of SDS-resistant protein attachment (see, for example, MacDonald et al 2008;Yin et al 2009d;Nosworthy et al 2007;Kondyurin et al 2008b, c;Bax et al 2009), rivalling those observed on the most hydrophobic of surfaces examined in the earlier studies. Figure 4 shows where the data obtained on the energetic ion-treated surfaces lie in relation to the adsorption curve of Kiaei et al (1992).…”

Section: Retention Of Activity After Freeze Dryingmentioning

confidence: 66%

“…At least in part this is likely to be related to the slower hydrophobic recovery of the ion-treated samples. Low energy plasma treatments typically lower the contact angle with water in a nonpermanent way Kondyurin et al 2009b) while the energetic ion treatment crosslinks the subsurface and this limits the ability for molecules to rotate and diffuse to replace the modified surface (see "Longevity of protein function").…”

Section: Plasma Modification Of Polymers For Covalent Protein Immobilmentioning

confidence: 99%

“…These chemical bonds and the remaining free radicals are polar and their presence on the surface imparts a hydrophilic character as observed by a decrease of the water contact angle compared to an untreated polymer surface. Over time, the concentration of the oxygen containing groups gradually further increases (Kondyurin et al 2009b).…”

Section: Surface Structure Of Plasma Prepared Surfacesmentioning

confidence: 99%

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Plasma modified surfaces for covalent immobilization of functional biomolecules in the absence of chemical linkers: towards better biosensors and a new generation of medical implants

2010

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Plasma modification and plasma polymer deposition are valuable technologies for the preparation of surfaces for the covalent binding of biomolecules for applications such as biosensors, medical prostheses, and diagnostic devices as well as surfaces for enzyme-mediated reactions. Covalency is conveniently tested by the ability of the surface to retain the attached molecules after vigorous washing with sodium dodecyl sulphate (SDS). Covalency is indicated if the fraction of protein retained lies above the curve characteristic of physisorption. Confidence in covalency is strengthened when the washing protocol is aggressive enough to remove all adsorbed protein from a control significantly more hydrophobic than the test surface. The use of linker chemistry to space the molecules from the surface is in some cases beneficial. However, the use of linker chemistry is not necessary to retain molecular function for long periods when the polymer surface is modified by energetic bombardment. The energetic bombardment retains hydrophilicity of the surface by crosslinking the subsurface, and this appears to facilitate retention of protein function. Energetic bombardment also increases the functional life of molecules immobilized and then freeze dried on plasma-modified surfaces. Analysis of the surfaces shows that the covalent binding mechanism is related to the presence of free radicals on the surface and in the subsurface regions. The unpaired electrons associated with the radicals appear to be mobile within the modified region and can diffuse to the surface to take part in binding interactions. Proactive implantable devices can make use of these principles of covalent attachment by seeding the surface of an implant with a biomolecule that elicits the desired interaction with cells and prevents undesirable responses.

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Section: Retention Of Activity After Freeze Dryingmentioning

confidence: 66%

Section: Plasma Modification Of Polymers For Covalent Protein Immobilmentioning

confidence: 99%

Section: Surface Structure Of Plasma Prepared Surfacesmentioning

confidence: 99%

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Plasma modified surfaces for covalent immobilization of functional biomolecules in the absence of chemical linkers: towards better biosensors and a new generation of medical implants

2010

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“…The structure's capacity to react with atmospheric oxygen is reduced as it is transformed into a dense amorphous carbon structure at high fluences. 49 In the case of polymers, such as polyimide, that contain oxygen as part of The Journal of Physical Chemistry C Article their monomeric units, the result of ion implantation is typically a reduction in the oxygen content of the surface layer, 47 as a significant portion of the incorporated oxygen forms volatile species during ion irradiation and diffuses out of the structure.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Depth-Resolved Structural and Compositional Characterization of Ion-Implanted Polystyrene that Enables Direct Covalent Immobilization of Biomolecules

et al. 2015

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A polystyrene film spun onto polished silicon substrates was implanted with argon ions using plasma immersion ion implantation (PIII) to activate its surface for single-step immobilization of biological molecules. The film was subsequently investigated by X-ray and neutron reflectometry, ultraviolet (UV)−visible (vis) and Fourier transform infrared (FTIR) ellipsometry, FTIR and Raman spectroscopy, as well as nuclear reaction analysis to determine the structural and compositional transformations associated with the surface activation. The ion irradiation resulted in a significant densification of the carbon structure, which was accompanied by hydrogen loss. The density and hydrogen profiles in the modified surface layers were found to agree with the expected depths of ion implantation as calculated by the Stopping and Range of Ions in Matter (SRIM) software. The data demonstrate that the reduction in film thickness is due to ion-induced densification rather than the removal of material by etching. Characterization by FTIR, atomic force microscopy (AFM), ellipsometry, and X-ray reflectometry shows that polystyrene films modified in this way immobilize dense layers of protein (tropoelastin) directly from solution. A substantial fraction of the immobilized protein layer remains after rigorous washing with sodium dodecyl sulfate solution, indicating that its immobilization is by covalent bonding.

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“…3) spectrums of the treated and untreated fibers illustrates the appearance of stretching vibration of hydroxyl groups ( (OH) at 3200-3600 cm −1 ), stretching vibration of carbonyl groups ( (C O) at ∼1710 cm −1 ), and stretching vibration of C O C groups (at ∼1100 cm −1 ). These groups change the surface chemistry and surface energy of the fibers [36] which, consequently, affect the adhesion characteristics of the fibers. Considering the absorption peak of in-plane bending (scissoring) vibration of CH 2 groups (ı s at 1464 cm −1 ), which are not changed during corona treatment, as internal reference, the ratio of (C O) area /ı s (CH 2 ) was calculated.…”

Section: Discussionmentioning

confidence: 99%

Ultra-high-molecular-weight polyethylene fiber reinforced dental composites: Effect of fiber surface treatment on mechanical properties of the composites

2015

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Mechanisms for surface energy changes observed in plasma immersion ion implanted polyethylene: The roles of free radicals and oxygen-containing groups

Cited by 64 publications

References 27 publications

Plasma modified surfaces for covalent immobilization of functional biomolecules in the absence of chemical linkers: towards better biosensors and a new generation of medical implants

Plasma modified surfaces for covalent immobilization of functional biomolecules in the absence of chemical linkers: towards better biosensors and a new generation of medical implants

Depth-Resolved Structural and Compositional Characterization of Ion-Implanted Polystyrene that Enables Direct Covalent Immobilization of Biomolecules

Ultra-high-molecular-weight polyethylene fiber reinforced dental composites: Effect of fiber surface treatment on mechanical properties of the composites

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