Mechanisms for species differences in receptor-mediated carcinogenesis

Jc, Barrett

doi:10.1016/0027-5107(95)00145-x

Cited by 22 publications

(12 citation statements)

References 84 publications

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“…Also, for extrapolations among species, the toxicokinetics must be identical or differences have to be taken into account. Some of the factors that would affect the interspecies differences have been reviewed recently (Barrett 1995). In addition, species‐ and tissue‐specific differences in the binding properties, specificity and physicochemical properties of the AhR and the contribution of other P‐450 genes to HAH‐induced activities challenge the generalities of assumptions of the TEF approach.…”

Section: Toxic Equivalency Factor (Tef) Approach In Risk Assessmentmentioning

confidence: 99%

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Dioxin‐like and non‐dioxin like effects of polychlorinated biphenyls: Implications for risk assessment

Giesy

Kannan

2002

Lakes & Reservoirs

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Polychlorinated biphenyls (PCBs) are persistent, bioaccumulative and toxic contaminants in the environment. Individual PCB congeners exhibit different physicochemical properties and biological activities that result in different environmental distributions and toxicity profiles. The variable composition of PCB residues in environmental matrices and their different mechanisms of toxicity complicate the development of scientifically based regulations for risk assessment. Various approaches for the assessment of risks of PCBs have been critically examined. Recent developments in the toxic equivalency factor (TEF) approach for the assessment of toxic effects due to dioxin‐like PCBs have been examined. The PCB exposure studies that describe non‐dioxin‐like toxic effects, particularly neurobehavioural effects and their effective doses in animals, were compiled. A comparative assessment of effective doses for dioxin‐like and non‐dioxin‐like effects by PCBs has been made to evaluate the relative significance of non‐ortho and ortho‐substituted PCBs in risk assessment. Using mink as an example, relative merits and implications of using TEF and total PCB approaches for assessing the potential for toxic effects in wildlife were examined. There are several advantages and limitations associated with each method used for PCB risk assessment. Toxic effects due to coplanar PCBs occur at relatively smaller concentrations than those due to non‐dioxin‐like PCBs and, therefore, the TEF approach derives the risk assessment of PCBs in the environment. The need for the refinement of the TEF approach for more accurate assessment of risks is discussed.

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Section: Toxic Equivalency Factor (Tef) Approach In Risk Assessmentmentioning

confidence: 99%

“…The mechanisms of PCB toxicity and their dioxin‐like effects and carcinogenicity have been previously reviewed (Poland & Knutson 1982; Safe 1984; Silberhorn et al. 1990; Barrett 1995). However, information on the toxicological risk assessment of PCBs in wildlife is limited (Delzell et al.…”

Section: Introductionmentioning

confidence: 99%

Dioxin‐like and non‐dioxin like effects of polychlorinated biphenyls: Implications for risk assessment

Giesy

Kannan

2002

Lakes & Reservoirs

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“…The newest entry into this prediction melange is mechanism (8)(9)(10)(11)(12)); yet mechanisms of carcinogenesis, albeit exciting, remain virtually futuristic and must receive continuing study and verification before acceptance into the scientific, regulatory, and legislative complex (13)(14)(15). Unfortunately this has happened already.…”

Section: Introductionmentioning

confidence: 99%

Multicomponent Criteria for Predicting Carcinogenicity: Dataset of 30 NTP Chemicals

Huff¹,

Weisburger²,

Fung³

1996

Environmental Health Perspectives

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“…The impetus for the review by Russo (8). The uncertainty in our understanding of the relationships between the estrogen receptor and its various agonistic and antagonistic ligands is illustrative of the complexity of this issue.…”

Section: Relevance For Risk Assessmentmentioning

confidence: 99%

Mammary gland neoplasia.

Neumann

Crisp

Olin

1996

Environ Health Perspect

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Determining how findings of chemically induced carcinogenic effects in rodents can properly be interpreted for human health poses a continuing challenge to the risk assessment community. One approach begins by comparing and contrasting carcinogenic process in rodents and humans, identifying biologically significant similarities and differences and gaps in scientific knowledge and understanding. Russo and Russo (in this issue) use just such an approach to evaluate the current state of scientific understanding of the comparative mechanisms of mammary tumorigenesis in humans and rodents, particularly the role of reproductive hormones. This commentary describes the basis for this review and suggests some of the implications the report may have for human health risk assessment and for future research.

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Mechanisms for species differences in receptor-mediated carcinogenesis

Cited by 22 publications

References 84 publications

Dioxin‐like and non‐dioxin like effects of polychlorinated biphenyls: Implications for risk assessment

Dioxin‐like and non‐dioxin like effects of polychlorinated biphenyls: Implications for risk assessment

Multicomponent Criteria for Predicting Carcinogenicity: Dataset of 30 NTP Chemicals

Mammary gland neoplasia.

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