Mechanisms for initiation of food allergy by skin pre‐disposed to atopic dermatitis
Haoran Gao,
Allison E. Kosins,
Joan M. Cook‐Mills
Abstract:SummaryFood allergy can be life‐threatening and often develops early in life. In infants and children, loss‐of‐function mutations in skin barrier genes associate with food allergy. In a mouse model with skin barrier mutations (Flakey Tail, FT+/− mice), topical epicutaneous sensitization to a food allergen peanut extract (PNE), an environmental allergen Alternaria alternata (Alt) and a detergent induce food allergy and then an oral PNE‐challenge induces anaphylaxis. Exposures to these allergens and detergents c… Show more
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