Mechanisms for histamine H1 receptor-mediated vasodilation in isolated canine lingual arteries

Chiba, Shigetoshi; Tsukada, Miyoko

doi:10.1016/s0014-2999(97)10105-4

Cited by 8 publications

(12 citation statements)

References 24 publications

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“…Histamine has been proposed to play an important role in early inflammatory responses based on studies documenting elevated histamine levels in patients [1], effectiveness of histamine antagonists in acute inflammation [2][3][4], effects of histamine on vasodilatation and permeability of microvascular endothelium [5][6][7], and histamine enhancement of neuInflamm. res.…”

Section: Introductionmentioning

confidence: 99%

Polyclonal anti-histamine H 2 receptor antibodies detect differential expression of H 2 receptor protein in primary vascular cell types

Schneider

Rieß

Elbers

et al. 2004

Inflammation Research

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We conclude that the antibodies generated against the extra-cellular domain of the H2 receptor are specific and can be utilized to detect and quantify H2 receptor expression. Furthermore, the significant differences in H2 receptor expression in different vascular cell types might play a critical role in defining histamine induced cellular responses during physiological or pathophysiological processes.

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Section: Introductionmentioning

confidence: 99%

Polyclonal anti-histamine H 2 receptor antibodies detect differential expression of H 2 receptor protein in primary vascular cell types

Schneider

Rieß

Elbers

et al. 2004

Inflammation Research

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“…In 1996, Chiba and Tsukada 19 demonstrated that abundant functional M 3 and a few M 1 muscarinic acetylcholine receptors in the canine lingual artery, mediate marked vasodilation dependent on the presence of an intact endothelium. Chiba and Tsukada 20 also reported that histamine caused endothelium‐dependent vasodilation in this artery. In the present study, the vasoactive properties of kinins, which are well known as vasodilators in isolated blood vessels, were functionally characterized.…”

Section: Discussionmentioning

confidence: 65%

“…Vascular responses to a number of vasoactive substances in the canine isolated lingual arteries have been reported previously 17 –20 . In dogs, the tongue assists in reducing body temperature and heat stress (heavy exercise or whole body warming) will readily induce a vasodilation in the canine tongue 21 .…”

Section: Introductionmentioning

confidence: 95%

Bradykinin‐induced Vascular Responses in Dog Isolated Lingual Artery

Tsukada

Chiba

1999

Clin Exp Pharma Physio

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1. Kinin-induced vascular responses were studied and kinin receptor subtypes were characterized in canine isolated and preconstricted lingual arteries. 2. A low dose of bradykinin (BK; < 3 x 10(-14) mol) induced only vasodilation, while a higher dose of BK (> 3 x 10(-13) mol) frequently induced a biphasic response: a transient constriction followed by dilation. 3. The BK-induced vasodilation was mostly endothelium dependent but was also partly endothelium independent because although the dilation response was greatly reduced after removal of the endothelium, it was not completely abolished. 4. The dilation response to BK was significantly inhibited by the B2 kinin receptor antagonist HOE 140 and was partly reduced by indomethacin (10 mumol/L) (P < 0.05). 5. Bradykinin-induced vasoconstriction was enhanced in endothelium-denuded preparations. The constriction was significantly inhibited by HOE 140 (10(-10) mol/L). The BK-induced responses were not affected by the B1 kinin receptor antagonist des-Arg9-[Leu8]-BK (3 x 10(-11) mol/L). 6. The B1 kinin receptor agonist des-Arg9-BK (> 10(-12) mol/L) produced vasodilation in 60% of endothelium-intact preparations. In 20% of the endothelium-intact preparations des-Arg9-BK produced a biphasic response: weak vasoconstriction followed by weak vasodilation. The des-Arg9-BK-induced dilation and constriction were significantly inhibited by des-Arg9-[Leu8]-BK (3 x 10(-11) mol/L), but were not affected by HOE 140 (10(-10) mol/L). 7. In conclusion, it appears that both B1 and B2 kinin receptors are present in the dog lingual artery. Both receptor subtypes mediate either vasodilation or vasoconstriction and BK-induced vasodilation is mostly endothelium dependent, although it may also be partially prostaglandin dependent.

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“…[10]. H 1 receptor-mediated responses in endothelial cells include the ability of histamine to directly cause vasodilation [74], increased vascular permeability [75], the adhesion of neutrophils [19,76,77] and the release of stored vasoactive factors such as interleukin-8 [78] and P-selectin [76]. Therefore, one can reasonably conclude that long-term internalization of H 2 receptor protein might promote an enhanced histamine-induced inflammatory response by endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide mediates histamine induced down-regulation of H 2 receptor mRNA and internalization of the receptor protein (R1)

Schaefer¹,

Schneider²,

Rudroff

et al. 2003

Cellular and Molecular Life Sciences (CMLS)

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During agonist-dependent long-term stimulation of cells, histamine receptor subtypes are frequently down-regulated. However, the mechanisms underlying the modulation of receptor expression during long-term histamine stimulation have yet to be resolved. Based on our recently reported results showing an H1-mediated down-regulation of histamine H2 receptor mRNA in endothelial cells, our aim was to characterize the mechanism controlling rapid and long-term histamine-mediated modulation of H2 receptor expression in more detail. We were able to show that the histamine-induced down-regulation of H2 receptor mRNA and cell surface expression lasting for 24 h was accompanied by augmentation of the receptor protein level in the cytoplasmatic fraction of endothelial cells for this time period. Furthermore, changes in receptor protein levels in whole-cell lysate were negligible, indicating that the rapid and prolonged modulation of cell surface H2 receptor levels by histamine was regulated solely via internalization. The role of nitric oxide (NO) as a key mediator in histamine-stimulated cell responses was underlined by subsequent studies showing the attenuation of histamine-induced H2 receptor mRNA down-regulation and protein trafficking following NO synthase isozyme inhibition.

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Mechanisms for histamine H1 receptor-mediated vasodilation in isolated canine lingual arteries

Cited by 8 publications

References 24 publications

Polyclonal anti-histamine H 2 receptor antibodies detect differential expression of H 2 receptor protein in primary vascular cell types

Polyclonal anti-histamine H 2 receptor antibodies detect differential expression of H 2 receptor protein in primary vascular cell types

Bradykinin‐induced Vascular Responses in Dog Isolated Lingual Artery

Nitric oxide mediates histamine induced down-regulation of H 2 receptor mRNA and internalization of the receptor protein (R1)

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