“…Although Nek2A is an APC/C substrate, conclusive evidence that its destruction in mammalian cells depends only on APC/C Cdc20 , or that a different proteasomal targeting pathway contributes to its degradation, too, is lacking. Furthermore, the role of Cdc20 in directing APC/C-mediated Nek2A degradation is under debate (Kimata et al, 2008;Sedgwick et al, 2013). In contrast to cyclin A, even at high levels Nek2A, has not been found to interfere with the ability of BubR1 to bind Cdc20 (Sedgwick et al, 2013), indicating that Nek2A and cyclin A might differ in the way their destruction escapes control by the spindle checkpoint.…”