Mechanisms Controlling Maintenance and Exit of the CSF Arrest

Lorca, Thierry

doi:10.1002/9780470687970.ch13

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Pp2a-b55 Activity Is Required For Mitotic Exit1

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2012

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“…This arrest is caused by a cytoplasmic activity named the cytostatic factor (CSF). CSF inhibits the APC, thereby preventing cyclin B degradation and exit of meiosis (reviewed in Lorca & Castro 38 ). The CSF is constituted by the Mos-MAPK-Rsk pathway and the APC inhibitor Emi2.…”

Section: Pp2a-b55 Activity Is Required For Mitotic Exitmentioning

confidence: 99%

Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control

Lorca

2012

Genes & Cancer

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Mitotic division is induced by protein phosphorylation. For a long time the supported hypothesis was that mitotic entry and exit were the exclusive result of cyclin B-Cdk1 kinase activation and inactivation, whereas the phosphatase activity required to dephosphorylate mitotic substrates was thought to be constant during mitosis. Recent data demonstrate that phosphatase activity must also be tightly regulated to promote correct cell division. Here we describe the new pathway involved in phosphatase regulation and the questions that this discovery raises concerning the classic view of cell cycle regulation.

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Section: Pp2a-b55 Activity Is Required For Mitotic Exitmentioning

confidence: 99%

Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control

Lorca

2012

Genes & Cancer

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Mechanisms Controlling Maintenance and Exit of the CSF Arrest

Cited by 1 publication

References 57 publications

Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control

Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control

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