Mechanisms by which systemic salbutamol increases ventilation

Abstract

Systemic SAL imposes ventilatory demands by increasing metabolic rate and serum lactate. This may adversely affect patients with severe asthma with limited ventilatory reserve.

Salbutamol effects on systemic potassium dynamics during and following intense continuous and intermittent exercise

“…Salbutamol lowers resting plasma [K + ], whether administered intravenously (Leitch et al 1976;Whyte et al 1987;Tobin et al 2006), by ingestion (Collomp et al 2000;Edner and Jogestrand 1990;Hostrup et al 2014a;Grove et al 1995) or inhalation (Lipworth et al 1989;Bennett and Tattersfield 1997;Clark and Lipworth 1996). However, salbutamol effects on [K + ] during intense exercise remain unclear, due to previous methodological limitations.…”

Treating acute asthma – salbutamol may not always be the right answer

“…As respiratory rate increases to compensate for this, hyperinflation worsens and respiratory mechanics are affected, which results in respiratory muscle failure. 8,9 …”

Medical emergencies: pulmonary embolism and acute severe asthma

“…b 2 -adrenoceptor agonists cause tachycardia, hypokalaemia, hyperglycaemia and lactic acid production [87]. This combination of side-effects increases both myocardial and respiratory demands and can contribute to decompensation of either or both systems.…”