Mechanisms by which sleep disturbance contributes to osteoarthritis pain: A conceptual model

Smith, Michael T.; Quartana, Phillip J.; Okonkwo, Renata; Nasir, Adeel

doi:10.1007/s11916-009-0073-2

Cited by 124 publications

(115 citation statements)

References 72 publications

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“…In addition, increase sleep fragmentation and shorter sleep duration may promote hyperalgesia through increased inflammatory activity. 29 Nevertheless, the small effects observed in the present study should be considered with the qualification that they represent self-report responses observed from day-to-day; these small daily effects, however, may accumulate over years of coping with SCD and thus integratively represent a contributor to disease burden and poor quality of life in these patients. Future research and treatment studies should consider the interacting effects of sleep fragmentation and sleep duration and seek to determine if specifically altering sleep continuity in patients with SCD yields clinically meaningful changes in SCD pain.…”

Section: Discussionmentioning

confidence: 79%

The Effect of Sleep Continuity on Pain in Adults With Sickle Cell Disease

Moscou-Jackson

Finan²,

Campbell³

et al. 2015

The Journal of Pain

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This analysis examined the influence of quantifiable parameters of daily sleep continuity, primarily sleep duration and sleep fragmentation, on daily pain in adults with Sickle Cell Disease (SCD). Seventy-five adults with SCD completed baseline psychosocial measures and daily morning (sleep) and evening (pain) diaries over a three-month period. Mixed-effect modeling was used to examine daily between- and within-subjects effects of sleep continuity parameters on pain, as well as the synergistic effect of sleep fragmentation and sleep duration on pain. Results revealed nights of shorter sleep duration and time in bed, increased fragmentation, and less efficient sleep (relative to one’s own mean) were followed by days of greater pain severity. Further, the analgesic benefit of longer sleep duration was attenuated when sleep fragmentation was elevated. These results suggest that both the separate and combined effects of sleep duration and fragmentation should be considered in evaluating pain in adults with SCD.

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Section: Discussionmentioning

confidence: 79%

The Effect of Sleep Continuity on Pain in Adults With Sickle Cell Disease

Moscou-Jackson

Finan²,

Campbell³

et al. 2015

The Journal of Pain

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“…Interestingly, the multivariate analysis revealed that severity of sleep problems remained significant in the multivariate model of predictors of pain severity. It is plausible that physical pain disrupts sleep quality; however, sleep problems may also exacerbate pain (Morphy et al, 2007;Smith et al, 2009). In accordance with other research studies pointing toward a significant influence of pain on attention (Moore et al, 2009), we observed a significant bivariate association between pain and impulsivity.…”

Section: Discussionmentioning

confidence: 99%

Physical Pain in Alcohol-Dependent Patients Entering Treatment in Poland—Prevalence and Correlates

Jakubczyk

Ilgen

Bohnert

et al. 2015

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Chronic pain and problematic alcohol use commonly co-exist, as the use of alcohol is commonly considered a useful pain self-management strategy. The purpose of this study was to characterize pain and pain-related problems in a group of primary alcohol-dependent individuals entering treatment facilities. Method: A sample of 366 (73.5% men and 26.5% women) alcohol-dependent (according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria) subjects was recruited in alcohol treatment centers in Warsaw, Poland. Information was obtained about demographics, social functioning, sexual and physical abuse during childhood, and severity of alcohol and sleep problems as well as level of impulsivity and general psychopathology. The study group was divided into a "mild or no pain" group and a "moderate or greater pain" group. Results: Among the study group, 34.4% of individuals reported moderate or greater physical pain during the last 4 weeks. The statistical analysis revealed that the experience of physical pain was significantly associated with lower level of education, unemployment, experience of sexual abuse before 18 years of age, and severity of alcohol dependence as well as other potential predictors of relapse (impulsivity, sleep problems, general psychopathology). When entered into logistic regression analysis with other dependent variables, the level of general psychopathology, severity of sleep problems, age, and education were all significantly associated with pain severity. Conclusions: Physical pain is a prevalent and potentially impairing experience in adults seeking treatment for alcohol dependence.

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“…Even though the physiological interaction between sleep and pain in general-and in mild TBI in particularremains unclear, it is possible that central thalamic processes play a role in both complaints, with diffuse nociceptive inhibitory control and inflammation suggested as potential mechanisms. 45 The literature strongly associates pain with sleep problems in mTBI, based on questionnaires and reports. 22,25 Pain as well as post-traumatic stress disorder were also shown to be significantly associated with sleep problems, known as the ''polytrauma clinical triad.''…”

Section: Discussionmentioning

confidence: 99%

Rapid EEG Activity during Sleep Dominates in Mild Traumatic Brain Injury Patients with Acute Pain

Khoury

Chouchou

Amzica

et al. 2013

Journal of Neurotrauma

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Chronic pain is a highly prevalent post-concussion symptom occurring in a majority of patients with mild traumatic brain injury (mTBI). About half of patients with mTBI report sleep-wake disturbances. It is known that pain can alter sleep quality in this population, but the interaction between pain and sleep is not fully understood. This study aimed to identify how pain affects subjective sleep (Pittsburgh Sleep Quality Index [PSQI]), sleep architecture, and quantitative electroencephalographic (qEEG) brain activity after mTBI. Twenty-four mTBI patients complaining of sleep-wake disturbances, with and without pain (8 and 16, respectively), were recruited 45 (±22.7) days post-trauma on average. Data were compared with those of 18 healthy controls (no sleep or pain complaints). The PSQI, sleep architecture, and qEEG activity were analyzed. Pain was assessed using questionnaires and a 100-mm visual analogue scale. Patients with mTBI reported three times poorer sleep quality than controls on the PSQI. Sleep architecture significantly differed between patients with mTBI and controls but was within normal range. Global qEEG showed lower delta (deep sleep) and higher beta and gamma power (arousal) at certain EEG derivations in patients with mTBI compared with controls (p<0.04). Patients with mTBI with pain, however, showed greater increase in rapid EEG frequency bands, mostly during REM sleep, and beta bands in non-REM sleep compared with patients with mTBI without pain and controls (p<0.001). Pain in patients with mTBI was associated with more rapid qEEG activity, mostly during REM sleep, suggesting that pain is associated with poor sleep and is a critical factor in managing post-concussion symptoms.

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Mechanisms by which sleep disturbance contributes to osteoarthritis pain: A conceptual model

Cited by 124 publications

References 72 publications

The Effect of Sleep Continuity on Pain in Adults With Sickle Cell Disease

The Effect of Sleep Continuity on Pain in Adults With Sickle Cell Disease

Physical Pain in Alcohol-Dependent Patients Entering Treatment in Poland—Prevalence and Correlates

Rapid EEG Activity during Sleep Dominates in Mild Traumatic Brain Injury Patients with Acute Pain

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