Mechanisms by which pulsatile flow affects cross‐flow microfiltration

Li, Hongyu; Bertram, Christopher; Wiley, Dianne E.

doi:10.1002/aic.690440903

Cited by 51 publications

(19 citation statements)

References 20 publications

(21 reference statements)

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“…One solution is the use of oscillating or pulsatile crossflow to create a pattern of small flow reversals, or accelerating and decelerating crossflow, which reduces particle deposition on the filter and thereby increases filtration efficiency. Flow oscillations or pulsations increase crossflow filtration performance by destabilizing the concentration polarization boundary layer over the filter surface and by increasing the back-migration of particles from the region near the filter surface to the bulk flow region (Winzeler and Belfort, 1993;Li et al, 1998;Al-Bastaki and Abbas, 2001;Hilal et al, 2005;Wang et al, 2007).…”

Section: Raker Conditionmentioning

confidence: 99%

Intra-Oral Flow Patterns and Speeds in a Suspension-Feeding Fish With Gill Rakers RemovedVersusIntact

Smith

Sanderson

2008

The Biological Bulletin

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Oreochromis aureus, a species of tilapia, is a suspension-feeding fish that employs a pumping action to bring water into its mouth for filtering.To address questions about water flow inside the mouth, we used a microthermistor flow probe to determine the speed of intra-oral flow during suspension feeding in this species before and after surgical removal of gill rakers. Synchronization with high-speed external videotapes of the fish and high-speed video endoscopy inside the oropharyngeal cavity allowed the first correlation of oral actions with intra-oral flow patterns and speeds during feeding. This analysis established the occurrence of a brief reversal of flow ( approximately 80-ms duration) from posterior to anterior in the oropharyngeal cavity prior to every feeding pump (250-500-ms duration). In industrial crossflow filtration, oscillating or pulsatile flow increases filtration performance by enhancing the back-migration of particles from the region near the filter surface to the bulk flow region, thus reducing particle accumulation that can clog the filter. In endoscopic videotapes, these pre-pump reversals, as well as post-pump reversals ( approximately 500-ms duration), were observed to lift mucus and particles from the branchial arches for subsequent transport toward the esophagus. Intra-oral flow speeds were reduced markedly after removal of the gill rakers. We hypothesize that the decrease in crossflow speed during feeding pumps following the removal of gill rakers and mucus could be due to increased loss of water between the anterior branchial arches.

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Section: Raker Conditionmentioning

confidence: 99%

Intra-Oral Flow Patterns and Speeds in a Suspension-Feeding Fish With Gill Rakers RemovedVersusIntact

Smith

Sanderson

2008

The Biological Bulletin

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“…Under the following assumptions: (i) laminar flow, (ii) quasi-uniform filtration velocity along the channel v(x, y) = v(y), and (iii) V w y << U 0 , an analytical solution to this system can be proposed provided that Re w = Vw h is of the order of 1, (Li et al, 1998).…”

Section: Flow Characteristics In the Filtration Chambersmentioning

confidence: 99%

Analytical modeling of steady-state filtration process in an automatic self-cleaning filter

Meireles

Prat

Estachy

2015

Chemical Engineering Research and Design

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“…Li et al . [20] proposed a pulsatile flow to increase the efficiency of cross flow micro-filtration. Geng and others [21] arranged their cross flow channel in a spiral to reduce the device footprint.…”

Section: Introductionmentioning

confidence: 99%

A radial pillar device (RAPID) for continuous and high-throughput separation of multi-sized particles

Mehendale

Sharma²,

D’Costa³

et al. 2017

Preprint

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Pillar-based microfluidic sorting devices are preferred for isolation of rare cells due to their simple designs and passive operation. Dead-end pillar filters can efficiently capture large rare cells, such as, circulating tumor cells (CTCs), nucleated red blood cells (NRBCs), etc., but they get clogged easily. Cross flow filters are preferred for smaller rare particles (e.g. separating bacteria from blood), but they need additional buffer inlets and a large device footprint for efficient operation. We have designed a new microparticle separation device i.e. Radial Pillar Device (RAPID) that combines the advantages of dead-end and cross flow filters. RAPID can simultaneously isolate both large and small rare particles from a mixed population, while functioning for several hours without clogging. We have achieved simultaneous separation of 10µm and 2µm polystyrene particles from a mixture of 2 µm, 7 µm and 10 µm beads. RAPID achieved average separation purity and recovery in excess of ⟂ 90%. The throughput of our device (⟂ 3ml/min) is 10 and 100 times higher compared to cross flow and dead-end filters respectively, thereby justifying the name RAPID.

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Mechanisms by which pulsatile flow affects cross‐flow microfiltration

Abstract: The effect of pulsatile jlow on particle deposition during cross-jlow microfiltration was studied to establish the degree to which bachflushing and shear-rate changes induced during pulsation alter cake formation.

Cited by 51 publications

References 20 publications

Intra-Oral Flow Patterns and Speeds in a Suspension-Feeding Fish With Gill Rakers RemovedVersusIntact

Intra-Oral Flow Patterns and Speeds in a Suspension-Feeding Fish With Gill Rakers RemovedVersusIntact

Analytical modeling of steady-state filtration process in an automatic self-cleaning filter

A radial pillar device (RAPID) for continuous and high-throughput separation of multi-sized particles

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