Mechanisms Behind the Inhibition of Lung Adenocarcinoma Cell by Shikonin

Lan, Weihua; Wan, Shengbang; Gu, Wenling; Wang, Heyong; Zhou, Shunhua

doi:10.1007/s12013-014-0083-5

Cited by 18 publications

(20 citation statements)

References 32 publications

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“…It is effective in treating different kinds of cancers, including breast, prostate, ovarian and thyroid cancers, Ewing sarcoma, and myelomonocytic lymphoma [595][596][597][598][599][600]. Shikonin exerts anti-cancer effects mainly by inducing apoptosis, necroptosis, autophagy, cell cycle arrest, and by inhibiting cell proliferation, growth and metastasis [593,601,602].…”

Section: Shikoninmentioning

confidence: 99%

“…Shikonin is reported to inhibit cell growth by inducing cell cycle arrest and promoting apoptosis in human NSCLC A549, gallbladder cancer NOZ and EHGB-1, esophageal cancer EC109, and epidermoid carcinoma A-431 cells [601,[603][604][605]. It can also induce necroptosis via autophagy inhibition in human NSCLC A549 cells [593], and through ROS overproduction in human nasopharyngeal carcinoma 5-8F, and glioma SHG-44, U87 and U251 cells [606,607].…”

Section: Shikoninmentioning

confidence: 99%

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Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Shikoninmentioning

confidence: 99%

Section: Shikoninmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…2 The parasite mediated immune suppression increases the risk of collateral deadly infections like HIV. 9 It is extended as an antioxidant, 10 antimicrobial, [11][12][13] anti-fungal, 14 anti-lung cancer, 15,16 and our recent report against human chronic myeloid leukemia. 4,5 Our group recently reported that acetyl shikonin (AS), natural derivative of shikonin -a naphthoquinone, as a major component in dried root bark of Arnebia nobilis like others.…”

Section: Introductionmentioning

confidence: 99%

Acetyl shikonin induces IL-12, nitric oxide and ROS to kill intracellular parasite Leishmania donovani in infected hosts

et al. 2016

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Acetyl shikonin (AS)-a naphthoquinone, isolated from Arnebia nobilis, was tested against visceral leishmaniasis (VL) in this study. AS induced anti-VL activity was examined by number of intracellular amastigotes in Giemsa-stained BALB/C derived macrophages in vitro and hepatic-splenic parasite burden by stamp smear method in vivo. Mediators of AS endorsed anti-VL were studied by nitrite and reactive oxygen species (ROS) and were further confirmed using their inhibitors. The effect of AS on interleukin (IL)-12, and IL-10 were analyzed by ELISA and RT-PCR from infected macrophages. AS treatment caused a nitrite and ROS mediated decrease in parasite load in murine infected macrophages. These events associated with the up-regulation of the IL-12, and down regulated IL-10. In addition, AS efficient to decrease the hepatic and splenic parasite load and modulated the IL-12 and IL-10 ratio in splenocytes. In summary, this study revealed that AS confers the chemo-immunotherapeutic strategy against visceral leishmaniasis.

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“…Caspase-3/7 activation is responsible for the final step of apoptosis (31,32) and reflects the degree of apoptosis in various cancer cells (33). To determine whether the anti-proliferative effect of shikonin was associated with the induction of apoptosis, a fluorescence quantification assay was used.…”

Section: Discussionmentioning

confidence: 99%

Shikonin induces an anti‑tumor effect on murine mammary cancer via p38‑dependent apoptosis

Koizumi

Liu

et al. 2019

Oncol Rep

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Breast cancer is the most common malignancy in women. Apoptosis is important for tumor suppression and may delay cancer progression. It was found that shikonin induced apoptosis in 4T1 murine mammary cancer cells and MDA-MB-231 human breast cancer cells in vitro. Total p38 and c-Jun N-terminal kinase (JNK) levels were maintained in 4T1 cells, and p38 phosphorylation, but not JNK phosphorylation, was significantly increased. Caspase-3/7 activity was detected, which suggested that the p38 pathway, but not the JNK signaling pathway, induced apoptosis in 4T1 cells. The anti-tumor effects of shikonin on orthotopic mouse models were also examined. On day 7 after inoculation of 4T1 cells into mice, tumor volumes in the shikonin-treated and the control groups began to differ. On day 13, tumors were weighed, and shikonin was revealed to suppress tumor growth in the orthotopic 4T1 model in vivo. In conclusion, shikonin is a potential anti-tumor drug for breast cancer.

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Mechanisms Behind the Inhibition of Lung Adenocarcinoma Cell by Shikonin

Cited by 18 publications

References 32 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Acetyl shikonin induces IL-12, nitric oxide and ROS to kill intracellular parasite Leishmania donovani in infected hosts

Shikonin induces an anti‑tumor effect on murine mammary cancer via p38‑dependent apoptosis

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