Mechanisms and ways of transmission of SARS-CoV-2 coronavirus infection

Abstract

The relevance of the problem. A new coronavirus infection caused by the SARS-CoV-2 virus has created an emergency situation of international importance. The incidence of it is characterized by a rapid spread across all countries, high morbidity rates, severe complications and mortality. Despite the fact that there are currently vaccines, it is not yet possible to stop the infection. Of particular importance as a preventive measure is the impact on the second link of the epidemic process. In this connection, obtaining objective data on the mechanisms and ways of spreading the SARS-CoV-2 virus will allow for more rational preventive measures and significantly reduce the risk of transmission of infection. The aim is to analyze current data on the mechanisms and ways of spreading the COVID-19 pathogen from available literature sources and to consider possible measures to influence the second link of the epidemiological chain in order to reduce the risks of infection. Materials and methods. The selection of peer-reviewed literature published from 2019 to 2021 was carried out. in the PubMed database and e-Library.ru, as well as links in articles. To obtain statistical data, the Internet resources of the World Health Organization (WHO), open data of Rospotrebnadzor, the Ministry of Health of the Russian Federation, Rosstat were used. Results. Analysis of scientific sources containing information on the mechanisms and ways of transmission of the new coronavirus infection COVID-19 indicates that the authors in their publications mention almost all the mechanisms and ways of transmission of this disease, but to varying degrees of their significance. The main mechanism of the spread of the SARS-CoV-2 virus is aspiration with airborne and airborne dust transmission routes. At the same time, the effect of contact, fecal-oral mechanisms is not excluded, the probability of the implementation of the vertical mechanism of transmission of the pathogen from the mother to the child, as well as the genital tract, is being studied. An important measure for the prevention of a new infection is the impact on the second link of the epidemic process, especially ensuring the highly efficient operation of ventilation and air conditioning systems in medical institutions and public places with a massive crowd of people, as well as compliance with personal preventive measures and disinfection measures.