Mechanisms and Therapeutic Approaches for Peritoneal Adhesions: A Comprehensive Review

Stratakis, Konstantinos; Kalogiannis, Evangelos; Thanopoulos, Aristomenis; Grigoriadis, Georgios; Roditis, Spyridon; Kaliatsi, Eleni G.; Nikiteas, Nikolaos; Kontzoglou, Konstantinos; Περρέα, Δέσποινα

doi:10.21614/chirurgia.2840

Cited by 1 publication

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“…Another preventive approach is inherent in the surgical act, that is, using the utmost delicacy (when possible) or the least invasiveness possible. But still, we do not have enough concrete data to state that mini-surgery and robotic use for surgery are able to minimize adhesion formation [ 18 ]. Gene therapy is another developing area, with the aim of adequately inhibiting certain genes to reduce the excessive inflammatory response, but we do not yet have enough data to make any claims [ 18 ].…”

Section: Reviewmentioning

confidence: 99%

Peritoneal Adhesions in Osteopathic Medicine: Theory, Part 1

Bordoni,

Escher,

Girgenti

2023

Cureus

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Peritoneal adhesions form as a result of trauma to the abdomen, injuries resulting from surgery, and infections. These tissutal neoformations are innervated and vascularized, and with lymphatic vessels, adherence becomes a new and independent structure, capable of negatively influencing visceral functions. Adherent neogenesis can be asymptomatic or can be a source of pain, limiting the patient's quality of life. Although adhesiolysis remains the elective approach to eliminate adhesions, this therapeutic route prepares the peritoneal anatomical area to recur. The article reviews information on adhesion formation and peritoneal anatomy, probable subjective predispositions, and pathways that carry nociception. The text aims to be a theoretical basis for making new treatment suggestions for non-invasive osteopathic medicine, through a second part will be discussed in another article.

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Section: Reviewmentioning

confidence: 99%