Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

Mapp, P.I.; Walsh, David A.

doi:10.1038/nrrheum.2012.80

Cited by 437 publications

(400 citation statements)

References 84 publications

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“…One possible mechanism of the first immediate improvement is that decreasing abnormal blood flow somehow reduced the accompanying sensory nerve stimulation. It is already known that inflammation leads to angiogenesis and sensory nerve growth along new blood vessels in osteoarthritic joints [13]. In the immunohistochemical analysis, neovessels and accompanying nerve growth have been reported in synovium [14] and fat pads [15,16] of osteoarthritic joints.…”

Section: Discussionmentioning

confidence: 97%

Transcatheter Arterial Embolization as a Treatment for Medial Knee Pain in Patients with Mild to Moderate Osteoarthritis

Okuno

Korchi

Shinjo

et al. 2014

Cardiovasc Intervent Radiol

100

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Purpose Osteoarthritis is a common cause of pain and disability. Mild to moderate knee osteoarthritis that is resistant to nonsurgical options and not severe enough to warrant joint replacement represents a challenge in its management. On the basis of the hypothesis that neovessels and accompanying nerves are possible sources of pain, previous work demonstrated that transcatheter arterial embolization for chronic painful conditions resulted in excellent pain relief. We hypothesized that transcatheter arterial embolization can relieve pain associated with knee osteoarthritis. Methods Transcatheter arterial embolization for mild to moderate knee osteoarthritis using imipenem/cilastatin sodium or 75 lm calibrated Embozene microspheres as an embolic agent has been performed in 11 and three patients, respectively. We assessed adverse events and changes in Western Ontario and McMaster University Osteoarthritis Index (WOMAC) scores. Results Abnormal neovessels were identified within soft tissue surrounding knee joint in all cases by arteriography. No major adverse events were related to the procedures. Transcatheter arterial embolization rapidly improved WOMAC pain scores from 12.2 ± 1.9 to 3.3 ± 2.1 at 1 month after the procedure, with further improvement at 4 months (1.7 ± 2.2) and WOMAC total scores from 47.3 ± 5.8 to 11.6 ± 5.4 at 1 month, and to 6.3 ± 6.0 at 4 months. These improvements were maintained in most cases at the final follow-up examination at a mean of 12 ± 5 months (range 4-19 months). Conclusion Transcatheter arterial embolization for mild to moderate knee osteoarthritis was feasible, rapidly relieved resistant pain, and restored knee function.

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Section: Discussionmentioning

confidence: 97%

Transcatheter Arterial Embolization as a Treatment for Medial Knee Pain in Patients with Mild to Moderate Osteoarthritis

Okuno

Korchi

Shinjo

et al. 2014

Cardiovasc Intervent Radiol

100

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“…The presence of these reactions in both cohorts is noteworthy because these reactions have been implicated in the development of pain. Specifically, increased vascularization (angiogenesis) and sensory nerve growth are closely linked processes [5,24]; and tissue necrosis or cell death results in the release of proinflammatory cytokines and other factors that initiate persistent pain by directly activating nociceptive sensory neurons [6,38]. Both reactions can lead to maladaptive plasticity and neural disease states, which raises the question whether these tissue responses contributed to neuropathic pain in both fixed-and mobile-bearing L-TDR patients.…”

Section: Discussionmentioning

confidence: 99%

UHMWPE Wear Debris and Tissue Reactions Are Reduced for Contemporary Designs of Lumbar Total Disc Replacements

Veruva

Lanman

Isaza

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Lumbar total disc replacement (L-TDR) is a procedure used to relieve back pain and maintain mobility. Contemporary metal-on-polyethylene (MoP) L-TDRs were developed to address wear performance concerns about historical designs, but wear debris generation and periprosthetic tissue reactions for these newer implants have not been determined. Questions/purposes The purpose of this study was to determine (1) whether periprosthetic ultrahigh-molecularweight polyethylene (UHMWPE) wear debris and biological responses were present in tissues from revised contemporary MoP L-TDRs that contain conventional cores fabricated from c-inert-sterilized UHMWPE; (2) how fixed-versus mobile-bearing design affected UHMWPE wear particle number, shape, and size; and (3) how these wear particle characteristics compare with historical MoP L-TDRs that contain cores fabricated from c-air-sterilized UHMWPE. Methods We evaluated periprosthetic tissues from 11 patients who received eight fixed-bearing ProDisc-L and four mobile-bearing CHARITÉ contemporary L-TDRs with a mean implantation time of 4.1 and 2.7 years, respectively. Histologic analysis of tissues was performed to assess biological responses and polarized light microscopy was used to quantify number and size/shape characteristics of UHMWPE wear particles from the fixed-and mobile-bearing devices. Comparisons were made to previously reported particle data for historical L-TDRs. Results Five of seven (71%) fixed-bearing and one of four mobile-bearing L-TDR patient tissues contained at least 4 particles/mm 2 wear with associated macrophage infiltration. Tissues with wear debris were highly vascularized, whereas those without debris were more necrotic. Given the samples available, the tissue around mobile-bearing L-TDR was observed to contain 87% more, 11% rounder, and 11% lesselongated wear debris compared with tissues around fixedbearing devices; however, there were no significant differences. Compared with historical L-TDRs, UHMWPE particle number and circularity for contemporary L-TDRs were 99% less (p = 0.003) and 50% rounder (p = 0.003). Conclusions In this preliminary study, short-term results suggest there was no significant influence of fixed-or mobile-bearing designs on wear particle characteristics of contemporary L-TDRs, but conventional UHMWPE has notably improved the wear resistance of these devices compared with historical UHMWPE.

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“…Ангиогенез -процесс образования новых крове-носных сосудов в органе или ткани -также может уча-ствовать в формировании боли, поскольку рост крове-носных сосудов и сенсорных нейронов является инте-гративным процессом [39]. Повышение активности ан-гиогенеза у больных ОА наблюдали при росте остеофи-тов [40], в суставном хряще [28], синовии [41] и мениске [42].…”

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“…Повышение активности ан-гиогенеза у больных ОА наблюдали при росте остеофи-тов [40], в суставном хряще [28], синовии [41] и мениске [42]. Проангиогенными факторами, которые продуци-руются хондроцитами, синовиоцитами, а также в суб-хондральной кости и костном мозге, внутри сустава, при ОА являются простагландины, окись азота, цитоки-ны, хемокины и факторы роста, ключевым из которых является сосудистый эндотелиальный фактор роста (СЭФР) [39]. При этом суставной хрящ при ОА менее устойчив к ангиогенезу в связи с потерей протеоглика-нов, синтезом коллагенов типов I и X вокруг врастаю-щих сосудов, что представляет собой фенотипический сдвиг от хряща к костеобразованию после прорастания сосудов [43].…”

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“…При этом суставной хрящ при ОА менее устойчив к ангиогенезу в связи с потерей протеоглика-нов, синтезом коллагенов типов I и X вокруг врастаю-щих сосудов, что представляет собой фенотипический сдвиг от хряща к костеобразованию после прорастания сосудов [43]. Кроме того, неоваскуляризация связана с появлением боли при ОА, потому что сопровождается иннервацией сенсорными нейронами [39]. С другой стороны, исследования на животных показали, что, по-мимо снабжения кислородом и метаболитами тканей сустава при ОА [44], СЭФР может участвовать в процес-се их репарации [45].…”

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